The effect of genetic variations in the choline acetyltransferase gene (ChAT) on waterpipe tobacco smoking dependence
Introduction Waterpipe tobacco smoking (WS) is a popular form of tobacco use, globally. While the impact of genetic variations on smoking behavior has been well-investigated, few studies have examined this issue with regard to WS. In the current study, associations between choline acetyltransferase...
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doaj-aa404f22f5654d2a80cc9d197cbef3b32020-11-25T02:24:32ZengEuropean PublishingTobacco Induced Diseases1617-96252020-03-0118March10.18332/tid/118233118233The effect of genetic variations in the choline acetyltransferase gene (ChAT) on waterpipe tobacco smoking dependenceOmar F. Khabour0Rawan N. Abu-Eitah1Karem H. Alzoubi2Ahmed Abu-Siniyeh3Thomas Eissenberg4Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid, JordanDepartment of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid, JordanDepartment of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, JordanDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif, Kingdom of Saudi ArabiaDepartment of Psychology, Virginia Commonwealth University, Richmond, United StatesIntroduction Waterpipe tobacco smoking (WS) is a popular form of tobacco use, globally. While the impact of genetic variations on smoking behavior has been well-investigated, few studies have examined this issue with regard to WS. In the current study, associations between choline acetyltransferase gene (ChAT) rs1917810 and rs7094248 polymorphisms and WS dependence were examined. Methods Genotyping of rs1917810 and rs7094248 in 266 Jordanian waterpipe smokers was performed using RFLP-PCR. Dependence on WS was measured using the LWDS-10J scale. Results The frequency of rs1917810 G allele was 38.5% and that of the rs7094248 G allele was 40.8%. The rs1917810 was significantly associated with the WS dependence level (p<0.05). Carriers of the AA genotype of rs1917810 were more dependent on WS than those with GG genotype (p 0.05). Conclusions The rs1917810 in the ChAT gene might be associated with dependence on WS.http://www.journalssystem.com/tid/The-Effect-of-Genetic-Variations-in-Choline-Acetyltransferase-Gene-CHAT-on-Waterpipe,118233,0,2.htmltobaccowaterpipecholine acetyltransferase genedependencesnp |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Omar F. Khabour Rawan N. Abu-Eitah Karem H. Alzoubi Ahmed Abu-Siniyeh Thomas Eissenberg |
spellingShingle |
Omar F. Khabour Rawan N. Abu-Eitah Karem H. Alzoubi Ahmed Abu-Siniyeh Thomas Eissenberg The effect of genetic variations in the choline acetyltransferase gene (ChAT) on waterpipe tobacco smoking dependence Tobacco Induced Diseases tobacco waterpipe choline acetyltransferase gene dependence snp |
author_facet |
Omar F. Khabour Rawan N. Abu-Eitah Karem H. Alzoubi Ahmed Abu-Siniyeh Thomas Eissenberg |
author_sort |
Omar F. Khabour |
title |
The effect of genetic variations in the choline acetyltransferase
gene (ChAT) on waterpipe tobacco smoking dependence |
title_short |
The effect of genetic variations in the choline acetyltransferase
gene (ChAT) on waterpipe tobacco smoking dependence |
title_full |
The effect of genetic variations in the choline acetyltransferase
gene (ChAT) on waterpipe tobacco smoking dependence |
title_fullStr |
The effect of genetic variations in the choline acetyltransferase
gene (ChAT) on waterpipe tobacco smoking dependence |
title_full_unstemmed |
The effect of genetic variations in the choline acetyltransferase
gene (ChAT) on waterpipe tobacco smoking dependence |
title_sort |
effect of genetic variations in the choline acetyltransferase
gene (chat) on waterpipe tobacco smoking dependence |
publisher |
European Publishing |
series |
Tobacco Induced Diseases |
issn |
1617-9625 |
publishDate |
2020-03-01 |
description |
Introduction
Waterpipe tobacco smoking (WS) is a popular form of tobacco use,
globally. While the impact of genetic variations on smoking behavior has been
well-investigated, few studies have examined this issue with regard to WS. In
the current study, associations between choline acetyltransferase gene (ChAT)
rs1917810 and rs7094248 polymorphisms and WS dependence were examined.
Methods
Genotyping of rs1917810 and rs7094248 in 266 Jordanian waterpipe
smokers was performed using RFLP-PCR. Dependence on WS was measured
using the LWDS-10J scale.
Results
The frequency of rs1917810 G allele was 38.5% and that of the rs7094248
G allele was 40.8%. The rs1917810 was significantly associated with the WS
dependence level (p<0.05). Carriers of the AA genotype of rs1917810 were
more dependent on WS than those with GG genotype (p 0.05).
Conclusions
The rs1917810 in the ChAT gene might be associated with dependence
on WS. |
topic |
tobacco waterpipe choline acetyltransferase gene dependence snp |
url |
http://www.journalssystem.com/tid/The-Effect-of-Genetic-Variations-in-Choline-Acetyltransferase-Gene-CHAT-on-Waterpipe,118233,0,2.html |
work_keys_str_mv |
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