Biomarkers for Allergen Immunotherapy in Cedar Pollinosis
To initiate, monitor, and complete effective immunotherapy, biomarkers to predict and visualize the immune responses are needed. First, we need to identify the right candidate for immunotherapy. Secondly, the immune responses induced by immunotherapy should be monitored. For the first objective, ana...
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doaj-aa466324d77e403ebbf750c66af497282020-11-25T00:37:38ZengElsevierAllergology International1323-89302009-01-0158216317010.2332/allergolint.09-RAI-0097Biomarkers for Allergen Immunotherapy in Cedar PollinosisTakao Fujisawa0Mizuho Nagao1Yukiko Hiraguchi2Koa Hosoki3Reiko Tokuda4Satoko Usui5Sawako Masuda6Makito Shinoda7Akihiko Hashiguchi8Masao Yamaguchi9Institute for Clinical Research, Saitama, JapanInstitute for Clinical Research, Saitama, JapanInstitute for Clinical Research, Saitama, JapanInstitute for Clinical Research, Saitama, JapanInstitute for Clinical Research, Saitama, JapanDepartment of Otorhinolaryngology, Mie National Hospital, Mie, Saitama, JapanDepartment of Otorhinolaryngology, Mie National Hospital, Mie, Saitama, JapanDepartment of Special Analysis, BML, Inc., Saitama, JapanDepartment of Special Analysis, BML, Inc., Saitama, JapanDepartment of Allergy and Rheumatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.To initiate, monitor, and complete effective immunotherapy, biomarkers to predict and visualize the immune responses are needed. First, we need to identify the right candidate for immunotherapy. Secondly, the immune responses induced by immunotherapy should be monitored. For the first objective, analysis of polymorphisms of candidate genes may be helpful, but still be in development. Regarding biomarkers for immune responsese, there are numerous reports that evaluate immunotherapy-induced immune changes such as suppression of effector cells, deviation to Th1 cytokine production, and induction of regulatory T cells. No standardized methods, however, have been established. Among them, a functional assay of blocking IgG activity, the IgE-facilitated allergen binding assay, may be useful. We quantitated induced expression of an activation marker, CD203c, on basophils and found that the assay efficiently predicts sensitivity to particular allergen and severity of the allergen-induced symptoms. In patients who received rush immunotherapy for Japanese cedar pollinosis, reduction in CD203c expression after the therapy was observed, suggesting the utility of the test for monitoring immunotherapy.http://www.sciencedirect.com/science/article/pii/S1323893015306936basophilsCD203ccedar pollinosisIgG4immunotherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Takao Fujisawa Mizuho Nagao Yukiko Hiraguchi Koa Hosoki Reiko Tokuda Satoko Usui Sawako Masuda Makito Shinoda Akihiko Hashiguchi Masao Yamaguchi |
spellingShingle |
Takao Fujisawa Mizuho Nagao Yukiko Hiraguchi Koa Hosoki Reiko Tokuda Satoko Usui Sawako Masuda Makito Shinoda Akihiko Hashiguchi Masao Yamaguchi Biomarkers for Allergen Immunotherapy in Cedar Pollinosis Allergology International basophils CD203c cedar pollinosis IgG4 immunotherapy |
author_facet |
Takao Fujisawa Mizuho Nagao Yukiko Hiraguchi Koa Hosoki Reiko Tokuda Satoko Usui Sawako Masuda Makito Shinoda Akihiko Hashiguchi Masao Yamaguchi |
author_sort |
Takao Fujisawa |
title |
Biomarkers for Allergen Immunotherapy in Cedar Pollinosis |
title_short |
Biomarkers for Allergen Immunotherapy in Cedar Pollinosis |
title_full |
Biomarkers for Allergen Immunotherapy in Cedar Pollinosis |
title_fullStr |
Biomarkers for Allergen Immunotherapy in Cedar Pollinosis |
title_full_unstemmed |
Biomarkers for Allergen Immunotherapy in Cedar Pollinosis |
title_sort |
biomarkers for allergen immunotherapy in cedar pollinosis |
publisher |
Elsevier |
series |
Allergology International |
issn |
1323-8930 |
publishDate |
2009-01-01 |
description |
To initiate, monitor, and complete effective immunotherapy, biomarkers to predict and visualize the immune responses are needed. First, we need to identify the right candidate for immunotherapy. Secondly, the immune responses induced by immunotherapy should be monitored. For the first objective, analysis of polymorphisms of candidate genes may be helpful, but still be in development. Regarding biomarkers for immune responsese, there are numerous reports that evaluate immunotherapy-induced immune changes such as suppression of effector cells, deviation to Th1 cytokine production, and induction of regulatory T cells. No standardized methods, however, have been established. Among them, a functional assay of blocking IgG activity, the IgE-facilitated allergen binding assay, may be useful. We quantitated induced expression of an activation marker, CD203c, on basophils and found that the assay efficiently predicts sensitivity to particular allergen and severity of the allergen-induced symptoms. In patients who received rush immunotherapy for Japanese cedar pollinosis, reduction in CD203c expression after the therapy was observed, suggesting the utility of the test for monitoring immunotherapy. |
topic |
basophils CD203c cedar pollinosis IgG4 immunotherapy |
url |
http://www.sciencedirect.com/science/article/pii/S1323893015306936 |
work_keys_str_mv |
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