Harnessing Radical Chemistry via Electrochemical Transition Metal Catalysis
Summary: The merger of transition metal catalysis and electroorganic synthesis has recently emerged as a versatile platform for the development of highly enabling radical reactions in a sustainable fashion. Electrochemistry provides access to highly reactive radical species under extremely mild reac...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2020-12-01
|
Series: | iScience |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004220309937 |
id |
doaj-aa47c952e8ff458b9ec39fd529ce0609 |
---|---|
record_format |
Article |
spelling |
doaj-aa47c952e8ff458b9ec39fd529ce06092020-12-19T05:09:56ZengElsevieriScience2589-00422020-12-012312101796Harnessing Radical Chemistry via Electrochemical Transition Metal CatalysisJiaqing Lu0Yukang Wang1Terry McCallum2Niankai Fu3Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaBeijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA; Corresponding authorBeijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China; Corresponding authorSummary: The merger of transition metal catalysis and electroorganic synthesis has recently emerged as a versatile platform for the development of highly enabling radical reactions in a sustainable fashion. Electrochemistry provides access to highly reactive radical species under extremely mild reaction conditions from abundant native functionalities. Transition metal catalysts can be used as redox-active electrocatalysts to shuttle electrons, chiral information to organic substrates, and the reactive intermediates in the electrolytic systems. The combination of these strategies in this mechanistic paradigm thus makes the generation and utilization of radical species in a chemoselective manner and allows further application to more synthetically attractive enantioselective radical transformations. This perspective discusses key advances over the past few years in the field of electrochemical transition metal catalysis and demonstrates how the unique features of this strategy permit challenging or previously elusive transformations via radical pathways to be successfully achieved.http://www.sciencedirect.com/science/article/pii/S2589004220309937ChemistryOrganic ChemistryOrganic SynthesisElectrochemistryMolecular Electrochemistry |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiaqing Lu Yukang Wang Terry McCallum Niankai Fu |
spellingShingle |
Jiaqing Lu Yukang Wang Terry McCallum Niankai Fu Harnessing Radical Chemistry via Electrochemical Transition Metal Catalysis iScience Chemistry Organic Chemistry Organic Synthesis Electrochemistry Molecular Electrochemistry |
author_facet |
Jiaqing Lu Yukang Wang Terry McCallum Niankai Fu |
author_sort |
Jiaqing Lu |
title |
Harnessing Radical Chemistry via Electrochemical Transition Metal Catalysis |
title_short |
Harnessing Radical Chemistry via Electrochemical Transition Metal Catalysis |
title_full |
Harnessing Radical Chemistry via Electrochemical Transition Metal Catalysis |
title_fullStr |
Harnessing Radical Chemistry via Electrochemical Transition Metal Catalysis |
title_full_unstemmed |
Harnessing Radical Chemistry via Electrochemical Transition Metal Catalysis |
title_sort |
harnessing radical chemistry via electrochemical transition metal catalysis |
publisher |
Elsevier |
series |
iScience |
issn |
2589-0042 |
publishDate |
2020-12-01 |
description |
Summary: The merger of transition metal catalysis and electroorganic synthesis has recently emerged as a versatile platform for the development of highly enabling radical reactions in a sustainable fashion. Electrochemistry provides access to highly reactive radical species under extremely mild reaction conditions from abundant native functionalities. Transition metal catalysts can be used as redox-active electrocatalysts to shuttle electrons, chiral information to organic substrates, and the reactive intermediates in the electrolytic systems. The combination of these strategies in this mechanistic paradigm thus makes the generation and utilization of radical species in a chemoselective manner and allows further application to more synthetically attractive enantioselective radical transformations. This perspective discusses key advances over the past few years in the field of electrochemical transition metal catalysis and demonstrates how the unique features of this strategy permit challenging or previously elusive transformations via radical pathways to be successfully achieved. |
topic |
Chemistry Organic Chemistry Organic Synthesis Electrochemistry Molecular Electrochemistry |
url |
http://www.sciencedirect.com/science/article/pii/S2589004220309937 |
work_keys_str_mv |
AT jiaqinglu harnessingradicalchemistryviaelectrochemicaltransitionmetalcatalysis AT yukangwang harnessingradicalchemistryviaelectrochemicaltransitionmetalcatalysis AT terrymccallum harnessingradicalchemistryviaelectrochemicaltransitionmetalcatalysis AT niankaifu harnessingradicalchemistryviaelectrochemicaltransitionmetalcatalysis |
_version_ |
1724377595739373568 |