STUDY ON THE HEPATOPROTECTIVE EFFECT OF SILYBUM MARIANUM EXTRACT ON EXPERIMENTAL POISONING BY PARACETAMOL IN NMRI ALBINO MICE
Hepatoprotection is a matter of worldwide interest, since liver diseases are common, and liver transplant has increasedover the past years, drastically reducing the number of people able to meet the criteria for such a transplant. The experimental research in this paper aimed at evaluating the hepat...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Editura Universitatii din Pitesti
2017-12-01
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| Series: | Current Trends in Natural Sciences |
| Subjects: | |
| Online Access: | http://natsci.upit.ro/media/1615/paper-38.pdf |
| Summary: | Hepatoprotection is a matter of worldwide interest, since liver diseases are common, and liver transplant has increasedover the past years, drastically reducing the number of people able to meet the criteria for such a transplant. The experimental research in this paper aimed at evaluating the hepatoprotective capacity of Silybum marianum species (thistle). In order to fulfil the purpose of the paper, thistle was administrated as hydr alcoholic extracts to animals, i.e. albino mice-NMRI strain. We used paracetamol solution for infusion known as Perfalgan (Bristol-Myers Squibb). The dose used was 400mg/kg/bod y substance, and we administrated ethanolic extracts of Sylibum marianum after the paracetamol poisoning. We conducted the research using biochemical methods and techniques, potential structural and functional changes occurred in the experimental animals’ internal organs poisoned with perfalgan then treated with Silybum marianum plant extract. |
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| ISSN: | 2284-953X 2284-953X |