Association of lincRNA-p21 Haplotype with Coronary Artery Disease in a Chinese Han Population
lincRNA-p21 plays an important role in the pathogenesis and progression of coronary artery disease (CAD). To date, the biological significance of polymorphisms in lincRNA-p21 on CAD risk remains unknown. Here we aimed to evaluate the influence of lincRNA-p21 polymorphisms on individual susceptibilit...
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Online Access: | http://dx.doi.org/10.1155/2016/9109743 |
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doaj-aa5728e1623e4dbfaaab9ca3f4a80fd92020-11-24T22:39:15ZengHindawi LimitedDisease Markers0278-02401875-86302016-01-01201610.1155/2016/91097439109743Association of lincRNA-p21 Haplotype with Coronary Artery Disease in a Chinese Han PopulationSai-sai Tang0Jie Cheng1Meng-yun Cai2Xi-li Yang3Xin-guang Liu4Bi-ying Zheng5Xing-dong Xiong6Institute of Aging Research, Guangdong Medical University, Dongguan 523808, ChinaInstitute of Aging Research, Guangdong Medical University, Dongguan 523808, ChinaInstitute of Aging Research, Guangdong Medical University, Dongguan 523808, ChinaDepartment of Cardiovascular Disease, The First People’s Hospital of Foshan, Foshan 528000, ChinaInstitute of Aging Research, Guangdong Medical University, Dongguan 523808, ChinaKey Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan 523808, ChinaInstitute of Aging Research, Guangdong Medical University, Dongguan 523808, ChinalincRNA-p21 plays an important role in the pathogenesis and progression of coronary artery disease (CAD). To date, the biological significance of polymorphisms in lincRNA-p21 on CAD risk remains unknown. Here we aimed to evaluate the influence of lincRNA-p21 polymorphisms on individual susceptibility to CAD. Genotyping of four tagSNPs (rs9380586, rs4713998, rs6930083, and rs6931097) within lincRNA-p21 gene was performed in 615 CAD and 655 controls. The haplotype analysis showed that the haplotype G-A-A-G (rs9380586-rs4713998-rs6930083-rs6931097) was statistically significantly associated with the reduced risk for CAD (OR = 0.78, P = 0.023). Stratified analysis revealed that G-A-A-G haplotype was at a significantly lower risk for myocardial infarction (MI) (OR = 0.68, P = 0.010). We also found that haplotype G-A-A-G had a more pronounced decreased risk for premature CAD or MI subjects (OR = 0.67, P = 0.017 for premature CAD, and OR = 0.65, P = 0.041 for premature MI, resp.). Our data provide the first evidence that the G-A-A-G haplotype of lincRNA-p21 is associated with decreased risk of CAD and MI, particularly among premature CAD/MI in the Chinese Han population. Further studies with more subjects and in diverse ethnic populations are warranted to clarify the general validity of our findings.http://dx.doi.org/10.1155/2016/9109743 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sai-sai Tang Jie Cheng Meng-yun Cai Xi-li Yang Xin-guang Liu Bi-ying Zheng Xing-dong Xiong |
spellingShingle |
Sai-sai Tang Jie Cheng Meng-yun Cai Xi-li Yang Xin-guang Liu Bi-ying Zheng Xing-dong Xiong Association of lincRNA-p21 Haplotype with Coronary Artery Disease in a Chinese Han Population Disease Markers |
author_facet |
Sai-sai Tang Jie Cheng Meng-yun Cai Xi-li Yang Xin-guang Liu Bi-ying Zheng Xing-dong Xiong |
author_sort |
Sai-sai Tang |
title |
Association of lincRNA-p21 Haplotype with Coronary Artery Disease in a Chinese Han Population |
title_short |
Association of lincRNA-p21 Haplotype with Coronary Artery Disease in a Chinese Han Population |
title_full |
Association of lincRNA-p21 Haplotype with Coronary Artery Disease in a Chinese Han Population |
title_fullStr |
Association of lincRNA-p21 Haplotype with Coronary Artery Disease in a Chinese Han Population |
title_full_unstemmed |
Association of lincRNA-p21 Haplotype with Coronary Artery Disease in a Chinese Han Population |
title_sort |
association of lincrna-p21 haplotype with coronary artery disease in a chinese han population |
publisher |
Hindawi Limited |
series |
Disease Markers |
issn |
0278-0240 1875-8630 |
publishDate |
2016-01-01 |
description |
lincRNA-p21 plays an important role in the pathogenesis and progression of coronary artery disease (CAD). To date, the biological significance of polymorphisms in lincRNA-p21 on CAD risk remains unknown. Here we aimed to evaluate the influence of lincRNA-p21 polymorphisms on individual susceptibility to CAD. Genotyping of four tagSNPs (rs9380586, rs4713998, rs6930083, and rs6931097) within lincRNA-p21 gene was performed in 615 CAD and 655 controls. The haplotype analysis showed that the haplotype G-A-A-G (rs9380586-rs4713998-rs6930083-rs6931097) was statistically significantly associated with the reduced risk for CAD (OR = 0.78, P = 0.023). Stratified analysis revealed that G-A-A-G haplotype was at a significantly lower risk for myocardial infarction (MI) (OR = 0.68, P = 0.010). We also found that haplotype G-A-A-G had a more pronounced decreased risk for premature CAD or MI subjects (OR = 0.67, P = 0.017 for premature CAD, and OR = 0.65, P = 0.041 for premature MI, resp.). Our data provide the first evidence that the G-A-A-G haplotype of lincRNA-p21 is associated with decreased risk of CAD and MI, particularly among premature CAD/MI in the Chinese Han population. Further studies with more subjects and in diverse ethnic populations are warranted to clarify the general validity of our findings. |
url |
http://dx.doi.org/10.1155/2016/9109743 |
work_keys_str_mv |
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