Investigation of the effect of short-term supplementation with curcuminoids on circulating small dense low-density lipoprotein concentrations in obese dyslipidemic subjects: A randomized double-blind placebo-controlled cross-over trial
<div><p class="abstract"><strong>BACKGROUND:</strong> Small dense low-density lipoprotein (sdLDL) is a sub-fraction of LDL considered to have the most atherogenic properties. The present trial aimed to assess changes in circulating sdLDL concentrations following sup...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Vesnu Publications
2014-09-01
|
Series: | ARYA Atherosclerosis |
Online Access: | http://arya.mui.ac.ir/index.php/arya/article/view/665 |
id |
doaj-aa5ad30ac73e47db9f91fb5c3c2e385c |
---|---|
record_format |
Article |
spelling |
doaj-aa5ad30ac73e47db9f91fb5c3c2e385c2020-11-24T23:58:51ZengVesnu PublicationsARYA Atherosclerosis1735-39552251-66382014-09-01105280286481Investigation of the effect of short-term supplementation with curcuminoids on circulating small dense low-density lipoprotein concentrations in obese dyslipidemic subjects: A randomized double-blind placebo-controlled cross-over trialMohsen Moohebati0Shima Yazdandoust1Amirhossein Sahebkar2Mohsen Mazidi3Zahra Sharghi-Shahri4Gordon Ferns5Majid Ghayour-Mobarhan6Associate Professor, Cardiovascular Research Center AND Department of Cardiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranBiochemistry of Nutrition Research Center AND School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranAssistant Professor, Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, IranBiochemistry of Nutrition Research Center AND School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranBiochemistry of Nutrition Research Center AND School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranProfessor, Brighton and Sussex Medical School, Mayfield House, University of Brighton, Brighton, UKAssociate Professor, Biochemistry of Nutrition Research Center AND School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran<div><p class="abstract"><strong>BACKGROUND:</strong> Small dense low-density lipoprotein (sdLDL) is a sub-fraction of LDL considered to have the most atherogenic properties. The present trial aimed to assess changes in circulating sdLDL concentrations following supplementation with curcuminoids, polyphenolic compounds with diverse potential cardio-protective functions.</p> <p class="abstract"><strong>METHODS:</strong> This study was designed as a randomized double-blind placebo-controlled cross-over trial. A total of 30 obese dyslipidemic subjects were assigned to curcuminoids (1 g/day) or placebo for 4 weeks, followed by a 2-week washout and then treatment with the alternate for another 4 weeks. Serum sdLDL was measured at baseline and weeks 4, 6, and 10 of the trial.</p> <p class="abstract"><strong>RESULTS:</strong><strong> </strong>Supplementation with curcuminoids (1 g/day) did not cause any significant alteration in serum sdLDL (P > 0.05).</p> <p class="abstract"><strong>CONCLUSION:</strong> Four-week supplementation with curcuminoids was not associated with any significant alteration in circulating sdLDL concentrations.</p> <p class="abstract"> </p> <p class="abstract"><strong>Keywords:</strong> Diferuloylmethane, Curcuma longa L., Turmeric, Cardiovascular Disease, Hypercholesterolemia, Atherosclerosis</p></div><p> </p>http://arya.mui.ac.ir/index.php/arya/article/view/665 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohsen Moohebati Shima Yazdandoust Amirhossein Sahebkar Mohsen Mazidi Zahra Sharghi-Shahri Gordon Ferns Majid Ghayour-Mobarhan |
spellingShingle |
Mohsen Moohebati Shima Yazdandoust Amirhossein Sahebkar Mohsen Mazidi Zahra Sharghi-Shahri Gordon Ferns Majid Ghayour-Mobarhan Investigation of the effect of short-term supplementation with curcuminoids on circulating small dense low-density lipoprotein concentrations in obese dyslipidemic subjects: A randomized double-blind placebo-controlled cross-over trial ARYA Atherosclerosis |
author_facet |
Mohsen Moohebati Shima Yazdandoust Amirhossein Sahebkar Mohsen Mazidi Zahra Sharghi-Shahri Gordon Ferns Majid Ghayour-Mobarhan |
author_sort |
Mohsen Moohebati |
title |
Investigation of the effect of short-term supplementation with curcuminoids on circulating small dense low-density lipoprotein concentrations in obese dyslipidemic subjects: A randomized double-blind placebo-controlled cross-over trial |
title_short |
Investigation of the effect of short-term supplementation with curcuminoids on circulating small dense low-density lipoprotein concentrations in obese dyslipidemic subjects: A randomized double-blind placebo-controlled cross-over trial |
title_full |
Investigation of the effect of short-term supplementation with curcuminoids on circulating small dense low-density lipoprotein concentrations in obese dyslipidemic subjects: A randomized double-blind placebo-controlled cross-over trial |
title_fullStr |
Investigation of the effect of short-term supplementation with curcuminoids on circulating small dense low-density lipoprotein concentrations in obese dyslipidemic subjects: A randomized double-blind placebo-controlled cross-over trial |
title_full_unstemmed |
Investigation of the effect of short-term supplementation with curcuminoids on circulating small dense low-density lipoprotein concentrations in obese dyslipidemic subjects: A randomized double-blind placebo-controlled cross-over trial |
title_sort |
investigation of the effect of short-term supplementation with curcuminoids on circulating small dense low-density lipoprotein concentrations in obese dyslipidemic subjects: a randomized double-blind placebo-controlled cross-over trial |
publisher |
Vesnu Publications |
series |
ARYA Atherosclerosis |
issn |
1735-3955 2251-6638 |
publishDate |
2014-09-01 |
description |
<div><p class="abstract"><strong>BACKGROUND:</strong> Small dense low-density lipoprotein (sdLDL) is a sub-fraction of LDL considered to have the most atherogenic properties. The present trial aimed to assess changes in circulating sdLDL concentrations following supplementation with curcuminoids, polyphenolic compounds with diverse potential cardio-protective functions.</p> <p class="abstract"><strong>METHODS:</strong> This study was designed as a randomized double-blind placebo-controlled cross-over trial. A total of 30 obese dyslipidemic subjects were assigned to curcuminoids (1 g/day) or placebo for 4 weeks, followed by a 2-week washout and then treatment with the alternate for another 4 weeks. Serum sdLDL was measured at baseline and weeks 4, 6, and 10 of the trial.</p> <p class="abstract"><strong>RESULTS:</strong><strong> </strong>Supplementation with curcuminoids (1 g/day) did not cause any significant alteration in serum sdLDL (P > 0.05).</p> <p class="abstract"><strong>CONCLUSION:</strong> Four-week supplementation with curcuminoids was not associated with any significant alteration in circulating sdLDL concentrations.</p> <p class="abstract"> </p> <p class="abstract"><strong>Keywords:</strong> Diferuloylmethane, Curcuma longa L., Turmeric, Cardiovascular Disease, Hypercholesterolemia, Atherosclerosis</p></div><p> </p> |
url |
http://arya.mui.ac.ir/index.php/arya/article/view/665 |
work_keys_str_mv |
AT mohsenmoohebati investigationoftheeffectofshorttermsupplementationwithcurcuminoidsoncirculatingsmalldenselowdensitylipoproteinconcentrationsinobesedyslipidemicsubjectsarandomizeddoubleblindplacebocontrolledcrossovertrial AT shimayazdandoust investigationoftheeffectofshorttermsupplementationwithcurcuminoidsoncirculatingsmalldenselowdensitylipoproteinconcentrationsinobesedyslipidemicsubjectsarandomizeddoubleblindplacebocontrolledcrossovertrial AT amirhosseinsahebkar investigationoftheeffectofshorttermsupplementationwithcurcuminoidsoncirculatingsmalldenselowdensitylipoproteinconcentrationsinobesedyslipidemicsubjectsarandomizeddoubleblindplacebocontrolledcrossovertrial AT mohsenmazidi investigationoftheeffectofshorttermsupplementationwithcurcuminoidsoncirculatingsmalldenselowdensitylipoproteinconcentrationsinobesedyslipidemicsubjectsarandomizeddoubleblindplacebocontrolledcrossovertrial AT zahrasharghishahri investigationoftheeffectofshorttermsupplementationwithcurcuminoidsoncirculatingsmalldenselowdensitylipoproteinconcentrationsinobesedyslipidemicsubjectsarandomizeddoubleblindplacebocontrolledcrossovertrial AT gordonferns investigationoftheeffectofshorttermsupplementationwithcurcuminoidsoncirculatingsmalldenselowdensitylipoproteinconcentrationsinobesedyslipidemicsubjectsarandomizeddoubleblindplacebocontrolledcrossovertrial AT majidghayourmobarhan investigationoftheeffectofshorttermsupplementationwithcurcuminoidsoncirculatingsmalldenselowdensitylipoproteinconcentrationsinobesedyslipidemicsubjectsarandomizeddoubleblindplacebocontrolledcrossovertrial |
_version_ |
1725449312346832896 |