TGFβ Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis

TGFβ Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis

Retaining the delicate balance in cell signaling activity is a prerequisite for the maintenance of physiological tissue homeostasis. Transforming growth factor-beta (TGFβ) signaling is an essential pathway that plays crucial roles during embryonic development as well as in adult tissues. Aberrant TG...

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Main Author: Panagiotis Papageorgis
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Journal of Oncology
Online Access:http://dx.doi.org/10.1155/2015/587193
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spelling doaj-aa5cbf97259f4c0794d16a2e62d3d9882020-11-24T23:41:23ZengHindawi LimitedJournal of Oncology1687-84501687-84692015-01-01201510.1155/2015/587193587193TGFβ Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and MetastasisPanagiotis Papageorgis0Department of Health Sciences, Program in Biological Sciences, European University Cyprus, 6 Diogenes Street, Engomi, 1516 Nicosia, CyprusRetaining the delicate balance in cell signaling activity is a prerequisite for the maintenance of physiological tissue homeostasis. Transforming growth factor-beta (TGFβ) signaling is an essential pathway that plays crucial roles during embryonic development as well as in adult tissues. Aberrant TGFβ signaling activity regulates tumor progression in a cancer cell-autonomous or non-cell-autonomous fashion and these effects may be tumor suppressing or tumor promoting depending on the cellular context. The fundamental role of this pathway in promoting cancer progression in multiple stages of the metastatic process, including epithelial-to-mesenchymal transition (EMT), is also becoming increasingly clear. In this review, we discuss the latest advances in the effort to unravel the inherent complexity of TGFβ signaling and its role in cancer progression and metastasis. These findings provide important insights into designing personalized therapeutic strategies against advanced cancers.http://dx.doi.org/10.1155/2015/587193
collection DOAJ
language English
format Article
sources DOAJ
author Panagiotis Papageorgis
spellingShingle Panagiotis Papageorgis
TGFβ Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis
Journal of Oncology
author_facet Panagiotis Papageorgis
author_sort Panagiotis Papageorgis
title TGFβ Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis
title_short TGFβ Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis
title_full TGFβ Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis
title_fullStr TGFβ Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis
title_full_unstemmed TGFβ Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis
title_sort tgfβ signaling in tumor initiation, epithelial-to-mesenchymal transition, and metastasis
publisher Hindawi Limited
series Journal of Oncology
issn 1687-8450
1687-8469
publishDate 2015-01-01
description Retaining the delicate balance in cell signaling activity is a prerequisite for the maintenance of physiological tissue homeostasis. Transforming growth factor-beta (TGFβ) signaling is an essential pathway that plays crucial roles during embryonic development as well as in adult tissues. Aberrant TGFβ signaling activity regulates tumor progression in a cancer cell-autonomous or non-cell-autonomous fashion and these effects may be tumor suppressing or tumor promoting depending on the cellular context. The fundamental role of this pathway in promoting cancer progression in multiple stages of the metastatic process, including epithelial-to-mesenchymal transition (EMT), is also becoming increasingly clear. In this review, we discuss the latest advances in the effort to unravel the inherent complexity of TGFβ signaling and its role in cancer progression and metastasis. These findings provide important insights into designing personalized therapeutic strategies against advanced cancers.
url http://dx.doi.org/10.1155/2015/587193
work_keys_str_mv AT panagiotispapageorgis tgfbsignalingintumorinitiationepithelialtomesenchymaltransitionandmetastasis
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