A systematic review of transfusion-transmitted malaria in non-endemic areas
Abstract Background Transfusion-transmitted malaria (TTM) is an accidental Plasmodium infection caused by whole blood or a blood component transfusion from a malaria infected donor to a recipient. Infected blood transfusions directly release malaria parasites in the recipient’s bloodstream triggerin...
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doaj-aa62acaf082a43cfb6b612f4407ce1a12020-11-25T02:52:55ZengBMCMalaria Journal1475-28752018-01-0117111410.1186/s12936-018-2181-0A systematic review of transfusion-transmitted malaria in non-endemic areasFederica Verra0Andrea Angheben1Elisa Martello2Giovanni Giorli3Francesca Perandin4Zeno Bisoffi5Centre for Tropical Diseases, Sacro Cuore-Don Calabria HospitalCentre for Tropical Diseases, Sacro Cuore-Don Calabria HospitalDepartment of Veterinary Sciences, University of TurinCentre for Tropical Diseases, Sacro Cuore-Don Calabria HospitalCentre for Tropical Diseases, Sacro Cuore-Don Calabria HospitalCentre for Tropical Diseases, Sacro Cuore-Don Calabria HospitalAbstract Background Transfusion-transmitted malaria (TTM) is an accidental Plasmodium infection caused by whole blood or a blood component transfusion from a malaria infected donor to a recipient. Infected blood transfusions directly release malaria parasites in the recipient’s bloodstream triggering the development of high risk complications, and potentially leading to a fatal outcome especially in individuals with no previous exposure to malaria or in immuno-compromised patients. A systematic review was conducted on TTM case reports in non-endemic areas to describe the epidemiological characteristics of blood donors and recipients. Methods Relevant articles were retrieved from Pubmed, EMBASE, Scopus, and LILACS. From each selected study the following data were extracted: study area, gender and age of blood donor and recipient, blood component associated with TTM, Plasmodium species, malaria diagnostic method employed, blood donor screening method, incubation period between the infected transfusion and the onset of clinical symptoms in the recipient, time elapsed between the clinical symptoms and the diagnosis of malaria, infection outcome, country of origin of the blood donor and time of the last potential malaria exposure. Results Plasmodium species were detected in 100 TTM case reports with a different frequency: 45% Plasmodium falciparum, 30% Plasmodium malariae, 16% Plasmodium vivax, 4% Plasmodium ovale, 2% Plasmodium knowlesi, 1% mixed infection P. falciparum/P. malariae. The majority of fatal outcomes (11/45) was caused by P. falciparum whilst the other fatalities occurred in individuals infected by P. malariae (2/30) and P. ovale (1/4). However, non P. falciparum fatalities were not attributed directly to malaria. The incubation time for all Plasmodium species TTM case reports was longer than what expected in natural infections. This difference was statistically significant for P. malariae (p = 0.006). A longer incubation time in the recipient together with a chronic infection at low parasite density of the donor makes P. malariae a subtle but not negligible risk for blood safety aside from P. falciparum. Conclusions TTM risk needs to be taken into account in order to enhance the safety of the blood supply chain from donors to recipients by means of appropriate diagnostic tools.http://link.springer.com/article/10.1186/s12936-018-2181-0Blood transfusionMalariaPlasmodiumBlood component transfusionTransfusion-transmitted malaria (TTM) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Federica Verra Andrea Angheben Elisa Martello Giovanni Giorli Francesca Perandin Zeno Bisoffi |
spellingShingle |
Federica Verra Andrea Angheben Elisa Martello Giovanni Giorli Francesca Perandin Zeno Bisoffi A systematic review of transfusion-transmitted malaria in non-endemic areas Malaria Journal Blood transfusion Malaria Plasmodium Blood component transfusion Transfusion-transmitted malaria (TTM) |
author_facet |
Federica Verra Andrea Angheben Elisa Martello Giovanni Giorli Francesca Perandin Zeno Bisoffi |
author_sort |
Federica Verra |
title |
A systematic review of transfusion-transmitted malaria in non-endemic areas |
title_short |
A systematic review of transfusion-transmitted malaria in non-endemic areas |
title_full |
A systematic review of transfusion-transmitted malaria in non-endemic areas |
title_fullStr |
A systematic review of transfusion-transmitted malaria in non-endemic areas |
title_full_unstemmed |
A systematic review of transfusion-transmitted malaria in non-endemic areas |
title_sort |
systematic review of transfusion-transmitted malaria in non-endemic areas |
publisher |
BMC |
series |
Malaria Journal |
issn |
1475-2875 |
publishDate |
2018-01-01 |
description |
Abstract Background Transfusion-transmitted malaria (TTM) is an accidental Plasmodium infection caused by whole blood or a blood component transfusion from a malaria infected donor to a recipient. Infected blood transfusions directly release malaria parasites in the recipient’s bloodstream triggering the development of high risk complications, and potentially leading to a fatal outcome especially in individuals with no previous exposure to malaria or in immuno-compromised patients. A systematic review was conducted on TTM case reports in non-endemic areas to describe the epidemiological characteristics of blood donors and recipients. Methods Relevant articles were retrieved from Pubmed, EMBASE, Scopus, and LILACS. From each selected study the following data were extracted: study area, gender and age of blood donor and recipient, blood component associated with TTM, Plasmodium species, malaria diagnostic method employed, blood donor screening method, incubation period between the infected transfusion and the onset of clinical symptoms in the recipient, time elapsed between the clinical symptoms and the diagnosis of malaria, infection outcome, country of origin of the blood donor and time of the last potential malaria exposure. Results Plasmodium species were detected in 100 TTM case reports with a different frequency: 45% Plasmodium falciparum, 30% Plasmodium malariae, 16% Plasmodium vivax, 4% Plasmodium ovale, 2% Plasmodium knowlesi, 1% mixed infection P. falciparum/P. malariae. The majority of fatal outcomes (11/45) was caused by P. falciparum whilst the other fatalities occurred in individuals infected by P. malariae (2/30) and P. ovale (1/4). However, non P. falciparum fatalities were not attributed directly to malaria. The incubation time for all Plasmodium species TTM case reports was longer than what expected in natural infections. This difference was statistically significant for P. malariae (p = 0.006). A longer incubation time in the recipient together with a chronic infection at low parasite density of the donor makes P. malariae a subtle but not negligible risk for blood safety aside from P. falciparum. Conclusions TTM risk needs to be taken into account in order to enhance the safety of the blood supply chain from donors to recipients by means of appropriate diagnostic tools. |
topic |
Blood transfusion Malaria Plasmodium Blood component transfusion Transfusion-transmitted malaria (TTM) |
url |
http://link.springer.com/article/10.1186/s12936-018-2181-0 |
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