How Does Antimicrobial Stewardship Affect Inappropriate Antibiotic Therapy in Urological Patients?

• Main Authors: Atsushi Uda, Katsumi Shigemura, Koichi Kitagawa, Kayo Osawa, Kenichiro Onuma, Shigeaki Inoue, Joji Kotani, Yonmin Yan, Yuzo Nakano, Tatsuya Nishioka, Ikuko Yano, Takayuki Miyara, Masato Fujisawa
• Format: Article
• Language: English
• Published: MDPI AG 2020-02-01
• Series: Antibiotics
• Subjects: antimicrobial stewardship team; intervention; urological patient
• Online Access: https://www.mdpi.com/2079-6382/9/2/63

Antimicrobial stewardship teams (ASTs) have been well-accepted in recent years; however, their clinical outcomes have not been fully investigated in urological patients. The purpose of this study was to evaluate the outcomes of intervention via a retrospective review of urological patients, as discussed in the AST meetings, who were treated with broad-spectrum antibiotics between 2014 and 2018 at the Department of Urology, Kobe University Hospital in Japan. Interventions were discussed in AST meetings for patients identified by pharmacists as having received inappropriate antibiotic therapy. The annual changes in numbers of inappropriate medications and culture submissions over five years at the urology department were statistically analyzed. Among 1,033 patients audited by pharmacists, inappropriate antibiotic therapy was found in 118 cases (11.4%). The numbers of inappropriate antibiotic use cases and of interventions for indefinite infections had significantly decreased during the study period (<i>p</i> = 0.012 and <i>p</i> = 0.033, respectively). However, the number of blood and drainage culture submissions had significantly increased (<i>p</i> = 0.009 and <i>p</i> = 0.035, respectively). Our findings suggest that urologists have probably become more familiar with infectious disease management through AST intervention, leading to a decrease in inappropriate antibiotic use and an increase in culture submissions.