Role of the nuclear membrane protein Emerin in front-rear polarity of the nucleus

During cell migration, cells are polarized with distinct front vs. rear regions but whether and how polarity is transmitted to the nucleus is unclear. Here the authors show that frontally-biased endoplasmic reticulum and the nuclear membrane protein Emerin contribute to front-rear nuclear cell polar...

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Bibliographic Details
Main Authors: Paulina Nastały, Divya Purushothaman, Stefano Marchesi, Alessandro Poli, Tobias Lendenmann, Gururaj Rao Kidiyoor, Galina V. Beznoussenko, Stefania Lavore, Orso Maria Romano, Dimos Poulikakos, Marco Cosentino Lagomarsino, Alexander A. Mironov, Aldo Ferrari, Paolo Maiuri
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15910-9
Description
Summary:During cell migration, cells are polarized with distinct front vs. rear regions but whether and how polarity is transmitted to the nucleus is unclear. Here the authors show that frontally-biased endoplasmic reticulum and the nuclear membrane protein Emerin contribute to front-rear nuclear cell polarity.
ISSN:2041-1723