Role of the nuclear membrane protein Emerin in front-rear polarity of the nucleus

Role of the nuclear membrane protein Emerin in front-rear polarity of the nucleus

During cell migration, cells are polarized with distinct front vs. rear regions but whether and how polarity is transmitted to the nucleus is unclear. Here the authors show that frontally-biased endoplasmic reticulum and the nuclear membrane protein Emerin contribute to front-rear nuclear cell polar...

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Main Authors: Paulina Nastały, Divya Purushothaman, Stefano Marchesi, Alessandro Poli, Tobias Lendenmann, Gururaj Rao Kidiyoor, Galina V. Beznoussenko, Stefania Lavore, Orso Maria Romano, Dimos Poulikakos, Marco Cosentino Lagomarsino, Alexander A. Mironov, Aldo Ferrari, Paolo Maiuri
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15910-9
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spelling doaj-aa70ea3edc634f5f887c9193f5d91f4f2021-05-11T08:16:50ZengNature Publishing GroupNature Communications2041-17232020-05-0111111210.1038/s41467-020-15910-9Role of the nuclear membrane protein Emerin in front-rear polarity of the nucleusPaulina Nastały0Divya Purushothaman1Stefano Marchesi2Alessandro Poli3Tobias Lendenmann4Gururaj Rao Kidiyoor5Galina V. Beznoussenko6Stefania Lavore7Orso Maria Romano8Dimos Poulikakos9Marco Cosentino Lagomarsino10Alexander A. Mironov11Aldo Ferrari12Paolo Maiuri13FIRC (Fondazione Italiana per la Ricerca sul Cancro) Institute of Molecular Oncology (IFOM)FIRC (Fondazione Italiana per la Ricerca sul Cancro) Institute of Molecular Oncology (IFOM)FIRC (Fondazione Italiana per la Ricerca sul Cancro) Institute of Molecular Oncology (IFOM)FIRC (Fondazione Italiana per la Ricerca sul Cancro) Institute of Molecular Oncology (IFOM)Laboratory of Thermodynamics in Emerging Technologies, Department of Mechanical and Process Engineering, ETH ZurichFIRC (Fondazione Italiana per la Ricerca sul Cancro) Institute of Molecular Oncology (IFOM)FIRC (Fondazione Italiana per la Ricerca sul Cancro) Institute of Molecular Oncology (IFOM)FIRC (Fondazione Italiana per la Ricerca sul Cancro) Institute of Molecular Oncology (IFOM)FIRC (Fondazione Italiana per la Ricerca sul Cancro) Institute of Molecular Oncology (IFOM)Laboratory of Thermodynamics in Emerging Technologies, Department of Mechanical and Process Engineering, ETH ZurichFIRC (Fondazione Italiana per la Ricerca sul Cancro) Institute of Molecular Oncology (IFOM)FIRC (Fondazione Italiana per la Ricerca sul Cancro) Institute of Molecular Oncology (IFOM)Laboratory of Thermodynamics in Emerging Technologies, Department of Mechanical and Process Engineering, ETH ZurichFIRC (Fondazione Italiana per la Ricerca sul Cancro) Institute of Molecular Oncology (IFOM)During cell migration, cells are polarized with distinct front vs. rear regions but whether and how polarity is transmitted to the nucleus is unclear. Here the authors show that frontally-biased endoplasmic reticulum and the nuclear membrane protein Emerin contribute to front-rear nuclear cell polarity.https://doi.org/10.1038/s41467-020-15910-9
collection DOAJ
language English
format Article
sources DOAJ
author Paulina Nastały
Divya Purushothaman
Stefano Marchesi
Alessandro Poli
Tobias Lendenmann
Gururaj Rao Kidiyoor
Galina V. Beznoussenko
Stefania Lavore
Orso Maria Romano
Dimos Poulikakos
Marco Cosentino Lagomarsino
Alexander A. Mironov
Aldo Ferrari
Paolo Maiuri
spellingShingle Paulina Nastały
Divya Purushothaman
Stefano Marchesi
Alessandro Poli
Tobias Lendenmann
Gururaj Rao Kidiyoor
Galina V. Beznoussenko
Stefania Lavore
Orso Maria Romano
Dimos Poulikakos
Marco Cosentino Lagomarsino
Alexander A. Mironov
Aldo Ferrari
Paolo Maiuri
Role of the nuclear membrane protein Emerin in front-rear polarity of the nucleus
Nature Communications
author_facet Paulina Nastały
Divya Purushothaman
Stefano Marchesi
Alessandro Poli
Tobias Lendenmann
Gururaj Rao Kidiyoor
Galina V. Beznoussenko
Stefania Lavore
Orso Maria Romano
Dimos Poulikakos
Marco Cosentino Lagomarsino
Alexander A. Mironov
Aldo Ferrari
Paolo Maiuri
author_sort Paulina Nastały
title Role of the nuclear membrane protein Emerin in front-rear polarity of the nucleus
title_short Role of the nuclear membrane protein Emerin in front-rear polarity of the nucleus
title_full Role of the nuclear membrane protein Emerin in front-rear polarity of the nucleus
title_fullStr Role of the nuclear membrane protein Emerin in front-rear polarity of the nucleus
title_full_unstemmed Role of the nuclear membrane protein Emerin in front-rear polarity of the nucleus
title_sort role of the nuclear membrane protein emerin in front-rear polarity of the nucleus
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-05-01
description During cell migration, cells are polarized with distinct front vs. rear regions but whether and how polarity is transmitted to the nucleus is unclear. Here the authors show that frontally-biased endoplasmic reticulum and the nuclear membrane protein Emerin contribute to front-rear nuclear cell polarity.
url https://doi.org/10.1038/s41467-020-15910-9
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