Oxidative Stress and Mitochondrial Dysfunction in Down’s Syndrome: Relevance to Aging and Dementia

Genome-wide gene deregulation and oxidative stress appear to be critical factors determining the high variability of phenotypes in Down’s syndrome (DS). Even though individuals with trisomy 21 exhibit a higher survival rate compared to other aneuploidies, most of them die in utero or early during po...

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Bibliographic Details
Main Authors: Pinar E. Coskun, Jorge Busciglio
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Current Gerontology and Geriatrics Research
Online Access:http://dx.doi.org/10.1155/2012/383170

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