Psychiatric Symptoms of Children and Adolescents With Mitochondrial Disorders: A Descriptive Case Series
Background: Mitochondrial disorders (MD) are a group of clinically heterogeneous genetic disorders resulting from dysfunction of the mitochondrial respiratory chain. Cognitive impairment is a common feature in adults with MD and psychiatric symptoms are associated with MD in up to 70% of the adult p...
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Frontiers Media S.A.
2021-07-01
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Series: | Frontiers in Psychiatry |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.685532/full |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elise Riquin Elise Riquin Elise Riquin Thomas Le Nerzé Natwin Pasquini Magalie Barth Clément Prouteau Estelle Colin Estelle Colin Patrizia Amati Bonneau Vincent Procaccio Patrick Van Bogaert Philippe Duverger Philippe Duverger Dominique Bonneau Dominique Bonneau Arnaud Roy Arnaud Roy |
spellingShingle |
Elise Riquin Elise Riquin Elise Riquin Thomas Le Nerzé Natwin Pasquini Magalie Barth Clément Prouteau Estelle Colin Estelle Colin Patrizia Amati Bonneau Vincent Procaccio Patrick Van Bogaert Philippe Duverger Philippe Duverger Dominique Bonneau Dominique Bonneau Arnaud Roy Arnaud Roy Psychiatric Symptoms of Children and Adolescents With Mitochondrial Disorders: A Descriptive Case Series Frontiers in Psychiatry mitochondrial disorders child adolescent & youth psychiatric symptom anxiety depression |
author_facet |
Elise Riquin Elise Riquin Elise Riquin Thomas Le Nerzé Natwin Pasquini Magalie Barth Clément Prouteau Estelle Colin Estelle Colin Patrizia Amati Bonneau Vincent Procaccio Patrick Van Bogaert Philippe Duverger Philippe Duverger Dominique Bonneau Dominique Bonneau Arnaud Roy Arnaud Roy |
author_sort |
Elise Riquin |
title |
Psychiatric Symptoms of Children and Adolescents With Mitochondrial Disorders: A Descriptive Case Series |
title_short |
Psychiatric Symptoms of Children and Adolescents With Mitochondrial Disorders: A Descriptive Case Series |
title_full |
Psychiatric Symptoms of Children and Adolescents With Mitochondrial Disorders: A Descriptive Case Series |
title_fullStr |
Psychiatric Symptoms of Children and Adolescents With Mitochondrial Disorders: A Descriptive Case Series |
title_full_unstemmed |
Psychiatric Symptoms of Children and Adolescents With Mitochondrial Disorders: A Descriptive Case Series |
title_sort |
psychiatric symptoms of children and adolescents with mitochondrial disorders: a descriptive case series |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychiatry |
issn |
1664-0640 |
publishDate |
2021-07-01 |
description |
Background: Mitochondrial disorders (MD) are a group of clinically heterogeneous genetic disorders resulting from dysfunction of the mitochondrial respiratory chain. Cognitive impairment is a common feature in adults with MD and psychiatric symptoms are associated with MD in up to 70% of the adult population. The aim of this study is to describe the psychiatric profile in children and adolescents with MD by focusing on the description of psychiatric symptoms.Methods: A cohort of 12 children and adolescents was prospectively recruited between February 2019 and February 2020 in the Reference Center for Mitochondrial Disorders of Angers (France). Participants and their parents completed an anamnestic form to provide socio-demographic data and completed the Global Assessment of Functioning scale, the Brief Psychiatric Rating Scale, the Child Depression Inventory, the Revised Children's Manifest Anxiety Scale, and the Conner's Rating Scale to evaluate the inattention/hyperactivity symptoms as well as the Quality of Life scale.Results: Four children (33.3%) were diagnosed with depressive symptoms. With regarding to anxiety, 6 children (50%) reported anxiety issues during the psychiatric interview and 3 children (25%) were suffering from anxiety according to the RCMAS scale. Compared to other children with chronic illnesses, the individuals in our cohort reported a lower overall quality of life score and lower scores in physical and social subscales.Conclusion: Our study shows that MD can lead to psychiatric disorders in children and adolescents, in particular anxiety and depression, as well as poor quality of life. This highlights the need for regular psychiatric assessments in individuals with developing brains, such as children and adolescents. We do not, however, have data regarding the neuropsychological profile of this population. |
topic |
mitochondrial disorders child adolescent & youth psychiatric symptom anxiety depression |
url |
https://www.frontiersin.org/articles/10.3389/fpsyt.2021.685532/full |
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doaj-aa9a67b9eeb246d5b22258954b65afbf2021-07-20T05:09:23ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-07-011210.3389/fpsyt.2021.685532685532Psychiatric Symptoms of Children and Adolescents With Mitochondrial Disorders: A Descriptive Case SeriesElise Riquin0Elise Riquin1Elise Riquin2Thomas Le Nerzé3Natwin Pasquini4Magalie Barth5Clément Prouteau6Estelle Colin7Estelle Colin8Patrizia Amati Bonneau9Vincent Procaccio10Patrick Van Bogaert11Philippe Duverger12Philippe Duverger13Dominique Bonneau14Dominique Bonneau15Arnaud Roy16Arnaud Roy17Department of Child and Adolescent Psychiatry, University Hospital of Angers, Angers, FranceUniversity Angers, [CHU Angers], LPPL EA4638, Angers, FranceUniversity Angers, [CHU Angers], INSERM, CNRS, MITOVASC, SFR ICAT, Angers, FranceDepartment of Child and Adolescent Psychiatry, University Hospital of Angers, Angers, FranceDepartment of Child and Adolescent Psychiatry, University Hospital of Angers, Angers, FranceDepartment of Genetics and National Reference Center for Mitochondrial Disorders, University Hospital of Angers, Angers, FranceDepartment of Genetics and National Reference Center for Mitochondrial Disorders, University Hospital of Angers, Angers, FranceUniversity Angers, [CHU Angers], INSERM, CNRS, MITOVASC, SFR ICAT, Angers, FranceDepartment of Genetics and National Reference Center for Mitochondrial Disorders, University Hospital of Angers, Angers, FranceDepartment of Genetics and National Reference Center for Mitochondrial Disorders, University Hospital of Angers, Angers, FranceDepartment of Genetics and National Reference Center for Mitochondrial Disorders, University Hospital of Angers, Angers, FranceDepartment of Pediatric Neurology, University Hospital of Angers, Angers, FranceDepartment of Child and Adolescent Psychiatry, University Hospital of Angers, Angers, FranceUniversity Angers, [CHU Angers], LPPL EA4638, Angers, FranceUniversity Angers, [CHU Angers], INSERM, CNRS, MITOVASC, SFR ICAT, Angers, FranceDepartment of Genetics and National Reference Center for Mitochondrial Disorders, University Hospital of Angers, Angers, FranceUniversity Angers, [CHU Angers], LPPL EA4638, Angers, FranceReference Center for Learning Disabilities, University Hospital of Nantes, Nantes, FranceBackground: Mitochondrial disorders (MD) are a group of clinically heterogeneous genetic disorders resulting from dysfunction of the mitochondrial respiratory chain. Cognitive impairment is a common feature in adults with MD and psychiatric symptoms are associated with MD in up to 70% of the adult population. The aim of this study is to describe the psychiatric profile in children and adolescents with MD by focusing on the description of psychiatric symptoms.Methods: A cohort of 12 children and adolescents was prospectively recruited between February 2019 and February 2020 in the Reference Center for Mitochondrial Disorders of Angers (France). Participants and their parents completed an anamnestic form to provide socio-demographic data and completed the Global Assessment of Functioning scale, the Brief Psychiatric Rating Scale, the Child Depression Inventory, the Revised Children's Manifest Anxiety Scale, and the Conner's Rating Scale to evaluate the inattention/hyperactivity symptoms as well as the Quality of Life scale.Results: Four children (33.3%) were diagnosed with depressive symptoms. With regarding to anxiety, 6 children (50%) reported anxiety issues during the psychiatric interview and 3 children (25%) were suffering from anxiety according to the RCMAS scale. Compared to other children with chronic illnesses, the individuals in our cohort reported a lower overall quality of life score and lower scores in physical and social subscales.Conclusion: Our study shows that MD can lead to psychiatric disorders in children and adolescents, in particular anxiety and depression, as well as poor quality of life. This highlights the need for regular psychiatric assessments in individuals with developing brains, such as children and adolescents. We do not, however, have data regarding the neuropsychological profile of this population.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.685532/fullmitochondrial disorderschildadolescent & youthpsychiatric symptomanxietydepression |