Association of microalbuminuria with left ventricular dysfunction in type 2 diabetes mellitus
Abstract Background The prevalence of diabetes mellitus is on rising trend in developing countries like India. In type 2 diabetes patients, albuminuria has been shown to predict development of dysfunction in other organ systems such as kidneys, nervous system, and retina and increase risk of cardiov...
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doaj-aaa246ceecc241a5b1d42c5fa010e8042021-08-22T11:06:14ZengSpringerOpenThe Egyptian Journal of Internal Medicine1110-77822090-90982021-08-013311610.1186/s43162-021-00057-wAssociation of microalbuminuria with left ventricular dysfunction in type 2 diabetes mellitusJiteshri Mehta0Varsha Y. Godbole1Kedar G. Mehta2A. Lalithambigai3Department of Medicine, GMERS Medical CollegeDepartment of Medicine, GMERS Medical CollegeDepartment of Community Medicine, GMERS Medical CollegeDepartment of Biochemistry, GMERS Medical CollegeAbstract Background The prevalence of diabetes mellitus is on rising trend in developing countries like India. In type 2 diabetes patients, albuminuria has been shown to predict development of dysfunction in other organ systems such as kidneys, nervous system, and retina and increase risk of cardiovascular (CV) morbidity and mortality. In this study, we plan to assess association of microalbuminuria with left ventricular dysfunction in type 2 diabetes mellitus. Results This cross-sectional study was conducted among 100 type 2 diabetes mellitus patients attending a tertiary care hospital in Gujarat, Western India. Based on urine albumin excretion status, they were divided in two groups of 50 each—normoalbuminuric and microalbuminuric patients. The mean FBS, PPBS, and HbA1c level was significantly lower in normoalbuminuric group compared to microalbuminuric group. There was an increase in cholesterol, triglyceride, VLDL, and LDL levels and decrease in HDL levels in microalbuminuric group as compared to normoalbuminuric group. Multivariate logistic regression analysis revealed that increase in age and a decrease in E/A ratio in patients with microalbuminuria was significantly associated with left ventricular diastolic dysfunction (LVDD). Conclusion The presence of microalbuminuria is associated with increased likelihood of LVDD in type 2 diabetes patients. Increase in age and decrease in E/A ratio show direct and independent association with LVDD in normotensive diabetic patients with microalbuminuria. Therefore, diabetes patients who have microalbuminuria should be regularly (or more frequently) evaluated for development of LVDD using Echocardiography. This can allow early identification of myocardial diastolic dysfunction.https://doi.org/10.1186/s43162-021-00057-wDiabetesIHDCADCHDMicroalbuminuria |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiteshri Mehta Varsha Y. Godbole Kedar G. Mehta A. Lalithambigai |
spellingShingle |
Jiteshri Mehta Varsha Y. Godbole Kedar G. Mehta A. Lalithambigai Association of microalbuminuria with left ventricular dysfunction in type 2 diabetes mellitus The Egyptian Journal of Internal Medicine Diabetes IHD CAD CHD Microalbuminuria |
author_facet |
Jiteshri Mehta Varsha Y. Godbole Kedar G. Mehta A. Lalithambigai |
author_sort |
Jiteshri Mehta |
title |
Association of microalbuminuria with left ventricular dysfunction in type 2 diabetes mellitus |
title_short |
Association of microalbuminuria with left ventricular dysfunction in type 2 diabetes mellitus |
title_full |
Association of microalbuminuria with left ventricular dysfunction in type 2 diabetes mellitus |
title_fullStr |
Association of microalbuminuria with left ventricular dysfunction in type 2 diabetes mellitus |
title_full_unstemmed |
Association of microalbuminuria with left ventricular dysfunction in type 2 diabetes mellitus |
title_sort |
association of microalbuminuria with left ventricular dysfunction in type 2 diabetes mellitus |
publisher |
SpringerOpen |
series |
The Egyptian Journal of Internal Medicine |
issn |
1110-7782 2090-9098 |
publishDate |
2021-08-01 |
description |
Abstract Background The prevalence of diabetes mellitus is on rising trend in developing countries like India. In type 2 diabetes patients, albuminuria has been shown to predict development of dysfunction in other organ systems such as kidneys, nervous system, and retina and increase risk of cardiovascular (CV) morbidity and mortality. In this study, we plan to assess association of microalbuminuria with left ventricular dysfunction in type 2 diabetes mellitus. Results This cross-sectional study was conducted among 100 type 2 diabetes mellitus patients attending a tertiary care hospital in Gujarat, Western India. Based on urine albumin excretion status, they were divided in two groups of 50 each—normoalbuminuric and microalbuminuric patients. The mean FBS, PPBS, and HbA1c level was significantly lower in normoalbuminuric group compared to microalbuminuric group. There was an increase in cholesterol, triglyceride, VLDL, and LDL levels and decrease in HDL levels in microalbuminuric group as compared to normoalbuminuric group. Multivariate logistic regression analysis revealed that increase in age and a decrease in E/A ratio in patients with microalbuminuria was significantly associated with left ventricular diastolic dysfunction (LVDD). Conclusion The presence of microalbuminuria is associated with increased likelihood of LVDD in type 2 diabetes patients. Increase in age and decrease in E/A ratio show direct and independent association with LVDD in normotensive diabetic patients with microalbuminuria. Therefore, diabetes patients who have microalbuminuria should be regularly (or more frequently) evaluated for development of LVDD using Echocardiography. This can allow early identification of myocardial diastolic dysfunction. |
topic |
Diabetes IHD CAD CHD Microalbuminuria |
url |
https://doi.org/10.1186/s43162-021-00057-w |
work_keys_str_mv |
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