Role of Two Efflux Proteins, ABCB1 and ABCG2 in Blood-Brain Barrier Transport of Bromocriptine in a Murine Model of MPTP-Induced Dopaminergic Degeneration
Purpose: MPTP-induced dopaminergic degeneration is an experimental model commonly used to explore Parkinson’s disease. Cerebral drug transport by ABC transporters in MPTP models has never been reported. Methods: We have investigated the transport of bromocriptine through the blood-brain barrier (B...
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Canadian Society for Pharmaceutical Sciences
2009-08-01
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| Series: | Journal of Pharmacy & Pharmaceutical Sciences |
| Online Access: | https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/1521 |
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doaj-aaa3ac3a93c24b359f2f68f8ac206e1b2020-11-25T04:07:15ZengCanadian Society for Pharmaceutical SciencesJournal of Pharmacy & Pharmaceutical Sciences1482-18262009-08-0112210.18433/J3B596Role of Two Efflux Proteins, ABCB1 and ABCG2 in Blood-Brain Barrier Transport of Bromocriptine in a Murine Model of MPTP-Induced Dopaminergic DegenerationSarah Vautier0Aline Milane1Christine Fernandez2Helene Chacun3Lucette Lacomblez4Robert Farinotti5University Paris Sud XIUniversity Paris Sud XIUniversity Paris Sud XIUniversity Paris Sud XIPitie-Salpetriere HospitalUniversity Paris Sud XIPurpose: MPTP-induced dopaminergic degeneration is an experimental model commonly used to explore Parkinson’s disease. Cerebral drug transport by ABC transporters in MPTP models has never been reported. Methods: We have investigated the transport of bromocriptine through the blood-brain barrier (BBB) in a MPTP model to understand the influence of the dopaminergic degeneration on ABCB1 and ABCG2. Results: We have shown that in MPTP treated mice, bromocriptine is widely distributed to brain (2.3-fold versus control, phttps://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/1521 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sarah Vautier Aline Milane Christine Fernandez Helene Chacun Lucette Lacomblez Robert Farinotti |
| spellingShingle |
Sarah Vautier Aline Milane Christine Fernandez Helene Chacun Lucette Lacomblez Robert Farinotti Role of Two Efflux Proteins, ABCB1 and ABCG2 in Blood-Brain Barrier Transport of Bromocriptine in a Murine Model of MPTP-Induced Dopaminergic Degeneration Journal of Pharmacy & Pharmaceutical Sciences |
| author_facet |
Sarah Vautier Aline Milane Christine Fernandez Helene Chacun Lucette Lacomblez Robert Farinotti |
| author_sort |
Sarah Vautier |
| title |
Role of Two Efflux Proteins, ABCB1 and ABCG2 in Blood-Brain Barrier Transport of Bromocriptine in a Murine Model of MPTP-Induced Dopaminergic Degeneration |
| title_short |
Role of Two Efflux Proteins, ABCB1 and ABCG2 in Blood-Brain Barrier Transport of Bromocriptine in a Murine Model of MPTP-Induced Dopaminergic Degeneration |
| title_full |
Role of Two Efflux Proteins, ABCB1 and ABCG2 in Blood-Brain Barrier Transport of Bromocriptine in a Murine Model of MPTP-Induced Dopaminergic Degeneration |
| title_fullStr |
Role of Two Efflux Proteins, ABCB1 and ABCG2 in Blood-Brain Barrier Transport of Bromocriptine in a Murine Model of MPTP-Induced Dopaminergic Degeneration |
| title_full_unstemmed |
Role of Two Efflux Proteins, ABCB1 and ABCG2 in Blood-Brain Barrier Transport of Bromocriptine in a Murine Model of MPTP-Induced Dopaminergic Degeneration |
| title_sort |
role of two efflux proteins, abcb1 and abcg2 in blood-brain barrier transport of bromocriptine in a murine model of mptp-induced dopaminergic degeneration |
| publisher |
Canadian Society for Pharmaceutical Sciences |
| series |
Journal of Pharmacy & Pharmaceutical Sciences |
| issn |
1482-1826 |
| publishDate |
2009-08-01 |
| description |
Purpose: MPTP-induced dopaminergic degeneration is an experimental model commonly used to explore Parkinson’s disease. Cerebral drug transport by ABC transporters in MPTP models has never been reported.
Methods: We have investigated the transport of bromocriptine through the blood-brain barrier (BBB) in a MPTP model to understand the influence of the dopaminergic degeneration on ABCB1 and ABCG2.
Results: We have shown that in MPTP treated mice, bromocriptine is widely distributed to brain (2.3-fold versus control, p |
| url |
https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/1521 |
| work_keys_str_mv |
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