Redox regulation of RyR-mediated Ca2+ release in muscle and neurons
Changes in the redox state of the intracellular ryanodine receptor/Ca2+ release channels of skeletal and cardiac muscle or brain cortex neurons affect their activity. In particular, agents that oxidize or alkylate free SH residues of the channel protein strongly enhance Ca2+-induced Ca2+ release, wh...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2004-01-01
|
Series: | Biological Research |
Subjects: | |
Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400007 |
id |
doaj-aaac834797704578a1800500bc6be893 |
---|---|
record_format |
Article |
spelling |
doaj-aaac834797704578a1800500bc6be8932020-11-24T22:50:03ZengBMCBiological Research0716-97600717-62872004-01-01374539552Redox regulation of RyR-mediated Ca2+ release in muscle and neuronsCECILIA HIDALGORICARDO BULLM. ISABEL BEHRENSPAULINA DONOSOChanges in the redox state of the intracellular ryanodine receptor/Ca2+ release channels of skeletal and cardiac muscle or brain cortex neurons affect their activity. In particular, agents that oxidize or alkylate free SH residues of the channel protein strongly enhance Ca2+-induced Ca2+ release, whereas reducing agents have the opposite effects. We will discuss here how modifications of highly reactive cysteine residues by endogenous redox agents or cellular redox state influence RyR channel activation by Ca2+ and ATP or inhibition by Mg2+. Possible physiological and pathological implications of these results on cellular Ca2+ signaling will be addressed as well.http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400007Redox stateryanodine receptorssarcoplasmic/endoplasmic reticulumcalcium releaseS-nitrosylationS-glutathionylation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
CECILIA HIDALGO RICARDO BULL M. ISABEL BEHRENS PAULINA DONOSO |
spellingShingle |
CECILIA HIDALGO RICARDO BULL M. ISABEL BEHRENS PAULINA DONOSO Redox regulation of RyR-mediated Ca2+ release in muscle and neurons Biological Research Redox state ryanodine receptors sarcoplasmic/endoplasmic reticulum calcium release S-nitrosylation S-glutathionylation |
author_facet |
CECILIA HIDALGO RICARDO BULL M. ISABEL BEHRENS PAULINA DONOSO |
author_sort |
CECILIA HIDALGO |
title |
Redox regulation of RyR-mediated Ca2+ release in muscle and neurons |
title_short |
Redox regulation of RyR-mediated Ca2+ release in muscle and neurons |
title_full |
Redox regulation of RyR-mediated Ca2+ release in muscle and neurons |
title_fullStr |
Redox regulation of RyR-mediated Ca2+ release in muscle and neurons |
title_full_unstemmed |
Redox regulation of RyR-mediated Ca2+ release in muscle and neurons |
title_sort |
redox regulation of ryr-mediated ca2+ release in muscle and neurons |
publisher |
BMC |
series |
Biological Research |
issn |
0716-9760 0717-6287 |
publishDate |
2004-01-01 |
description |
Changes in the redox state of the intracellular ryanodine receptor/Ca2+ release channels of skeletal and cardiac muscle or brain cortex neurons affect their activity. In particular, agents that oxidize or alkylate free SH residues of the channel protein strongly enhance Ca2+-induced Ca2+ release, whereas reducing agents have the opposite effects. We will discuss here how modifications of highly reactive cysteine residues by endogenous redox agents or cellular redox state influence RyR channel activation by Ca2+ and ATP or inhibition by Mg2+. Possible physiological and pathological implications of these results on cellular Ca2+ signaling will be addressed as well. |
topic |
Redox state ryanodine receptors sarcoplasmic/endoplasmic reticulum calcium release S-nitrosylation S-glutathionylation |
url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400007 |
work_keys_str_mv |
AT ceciliahidalgo redoxregulationofryrmediatedca2releaseinmuscleandneurons AT ricardobull redoxregulationofryrmediatedca2releaseinmuscleandneurons AT misabelbehrens redoxregulationofryrmediatedca2releaseinmuscleandneurons AT paulinadonoso redoxregulationofryrmediatedca2releaseinmuscleandneurons |
_version_ |
1725673637725339648 |