Persistent activity in a recurrent circuit underlies courtship memory in Drosophila
Recurrent connections are thought to be a common feature of the neural circuits that encode memories, but how memories are laid down in such circuits is not fully understood. Here we present evidence that courtship memory in Drosophila relies on the recurrent circuit between mushroom body gamma (MBγ...
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doaj-aab0bd12642b48b99ff386a34fc4bd1a2021-05-05T15:30:50ZengeLife Sciences Publications LtdeLife2050-084X2018-01-01710.7554/eLife.31425Persistent activity in a recurrent circuit underlies courtship memory in DrosophilaXiaoliang Zhao0https://orcid.org/0000-0001-8787-076XDaniela Lenek1Ugur Dag2Barry J Dickson3https://orcid.org/0000-0003-0715-892XKrystyna Keleman4https://orcid.org/0000-0003-2044-1981Janelia Research Campus, Ashburn, United StatesResearch Institute of Molecular Pathology, Vienna, AustriaJanelia Research Campus, Ashburn, United StatesJanelia Research Campus, Ashburn, United States; Queensland Brain Institute, University of Queensland, St Lucia, AustraliaJanelia Research Campus, Ashburn, United States; Research Institute of Molecular Pathology, Vienna, AustriaRecurrent connections are thought to be a common feature of the neural circuits that encode memories, but how memories are laid down in such circuits is not fully understood. Here we present evidence that courtship memory in Drosophila relies on the recurrent circuit between mushroom body gamma (MBγ), M6 output, and aSP13 dopaminergic neurons. We demonstrate persistent neuronal activity of aSP13 neurons and show that it transiently potentiates synaptic transmission from MBγ>M6 neurons. M6 neurons in turn provide input to aSP13 neurons, prolonging potentiation of MBγ>M6 synapses over time periods that match short-term memory. These data support a model in which persistent aSP13 activity within a recurrent circuit lays the foundation for a short-term memory.https://elifesciences.org/articles/31425memoryDrosophilamushroom bodyrecurrent circuitpersistent activitysynaptic plasticity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiaoliang Zhao Daniela Lenek Ugur Dag Barry J Dickson Krystyna Keleman |
spellingShingle |
Xiaoliang Zhao Daniela Lenek Ugur Dag Barry J Dickson Krystyna Keleman Persistent activity in a recurrent circuit underlies courtship memory in Drosophila eLife memory Drosophila mushroom body recurrent circuit persistent activity synaptic plasticity |
author_facet |
Xiaoliang Zhao Daniela Lenek Ugur Dag Barry J Dickson Krystyna Keleman |
author_sort |
Xiaoliang Zhao |
title |
Persistent activity in a recurrent circuit underlies courtship memory in Drosophila |
title_short |
Persistent activity in a recurrent circuit underlies courtship memory in Drosophila |
title_full |
Persistent activity in a recurrent circuit underlies courtship memory in Drosophila |
title_fullStr |
Persistent activity in a recurrent circuit underlies courtship memory in Drosophila |
title_full_unstemmed |
Persistent activity in a recurrent circuit underlies courtship memory in Drosophila |
title_sort |
persistent activity in a recurrent circuit underlies courtship memory in drosophila |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2018-01-01 |
description |
Recurrent connections are thought to be a common feature of the neural circuits that encode memories, but how memories are laid down in such circuits is not fully understood. Here we present evidence that courtship memory in Drosophila relies on the recurrent circuit between mushroom body gamma (MBγ), M6 output, and aSP13 dopaminergic neurons. We demonstrate persistent neuronal activity of aSP13 neurons and show that it transiently potentiates synaptic transmission from MBγ>M6 neurons. M6 neurons in turn provide input to aSP13 neurons, prolonging potentiation of MBγ>M6 synapses over time periods that match short-term memory. These data support a model in which persistent aSP13 activity within a recurrent circuit lays the foundation for a short-term memory. |
topic |
memory Drosophila mushroom body recurrent circuit persistent activity synaptic plasticity |
url |
https://elifesciences.org/articles/31425 |
work_keys_str_mv |
AT xiaoliangzhao persistentactivityinarecurrentcircuitunderliescourtshipmemoryindrosophila AT danielalenek persistentactivityinarecurrentcircuitunderliescourtshipmemoryindrosophila AT ugurdag persistentactivityinarecurrentcircuitunderliescourtshipmemoryindrosophila AT barryjdickson persistentactivityinarecurrentcircuitunderliescourtshipmemoryindrosophila AT krystynakeleman persistentactivityinarecurrentcircuitunderliescourtshipmemoryindrosophila |
_version_ |
1721459933652713472 |