Long non-coding RNA SPRY4-IT1 as a promising indicator for three field lymph-node dissection of thoracic esophageal carcinoma

Abstract Background Esophageal squamous cell carcinoma(ESCC) is one of the most common tumors worldwide. Esophagectomy with three-field lymph node dissection(3FLND) is the radical surgical procedure for esophageal cancer. However, 3FLND is not widely used due to it’s higher mortality rate and higher...

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Main Authors: Peng Qie, Qifan Yin, Xuejiao Xun, Yongbin Song, Shaohui Zhou, Huining Liu, Junpeng Feng, Ziqiang Tian
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Journal of Cardiothoracic Surgery
Subjects:
Online Access:https://doi.org/10.1186/s13019-021-01433-x
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spelling doaj-aab499e7d9e441c59a3559d33d290c1e2021-03-28T11:07:48ZengBMCJournal of Cardiothoracic Surgery1749-80902021-03-011611910.1186/s13019-021-01433-xLong non-coding RNA SPRY4-IT1 as a promising indicator for three field lymph-node dissection of thoracic esophageal carcinomaPeng Qie0Qifan Yin1Xuejiao Xun2Yongbin Song3Shaohui Zhou4Huining Liu5Junpeng Feng6Ziqiang Tian7Hebei Medical UniversityHebei General HospitalHebei General HospitalHebei General HospitalHebei General HospitalHebei General HospitalHebei Chest HospitalHebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor HospitalAbstract Background Esophageal squamous cell carcinoma(ESCC) is one of the most common tumors worldwide. Esophagectomy with three-field lymph node dissection(3FLND) is the radical surgical procedure for esophageal cancer. However, 3FLND is not widely used due to it’s higher mortality rate and higher incidence of postoperative complications. There is an urgent need to identify novel biomarkers that can guide the most proper lymph-node dissection in esophageal cancer patients. Method Ninety-two patients with thoracic ESCC undergoing 3FLND were enrolled into our study from the Department of Thoracic Surgery of the Fourth Hospital affiliated to the Hebei Medical University and Hebei General Hospital between Jun 2011 and Dec 2015. Retrospectively collected data from these 92 patients was used to explore the relationship between the lymph-node metastasis、recurrence and the SPRY4-IT1 expression level and to determine whether 3FLND should be performed in patients with thoracic ESCC. Results The findings revealed that the SPRY4-IT1 expression was significantly higher in esophageal cancer tissues than in adjacent noncancerous tissues. (P < 0.01). Furthermore, the high expression of SPRY4-IT1 was significantly correlated with tumor differentiation (P = 0.029), T classification (P = 0.013), lymph node metastasis(P = 0.022) and pathological stage (P = 0.001). The increased expression of SPRY4-IT1 was associated with a higher risk of cervical and superior mediastinal lymph-node metastasis(P = 0.039).However, no significant association was observed between the risk of cervical and superior mediastinal lymph-node recurrence and the SPRY4-IT1 expression level in the thoracic ESCC patients performed 3FLND(P = 0.509). Conclusions Our data support the assumption that the high expression of SPRY4-IT1 is associated with a high risk of lymph node metastasis and it has potential application as a indicator for guiding on three-field lymph node dissection in patients with thoracic ESCC. Randomized controlled trials with a large cohort of patients will be needed to confirm this conclusion in the future.https://doi.org/10.1186/s13019-021-01433-xEsophageal carcinomaSPRY4-IT1BiomarkerThree field lymph-node dissection
collection DOAJ
language English
format Article
sources DOAJ
author Peng Qie
Qifan Yin
Xuejiao Xun
Yongbin Song
Shaohui Zhou
Huining Liu
Junpeng Feng
Ziqiang Tian
spellingShingle Peng Qie
Qifan Yin
Xuejiao Xun
Yongbin Song
Shaohui Zhou
Huining Liu
Junpeng Feng
Ziqiang Tian
Long non-coding RNA SPRY4-IT1 as a promising indicator for three field lymph-node dissection of thoracic esophageal carcinoma
Journal of Cardiothoracic Surgery
Esophageal carcinoma
SPRY4-IT1
Biomarker
Three field lymph-node dissection
author_facet Peng Qie
Qifan Yin
Xuejiao Xun
Yongbin Song
Shaohui Zhou
Huining Liu
Junpeng Feng
Ziqiang Tian
author_sort Peng Qie
title Long non-coding RNA SPRY4-IT1 as a promising indicator for three field lymph-node dissection of thoracic esophageal carcinoma
title_short Long non-coding RNA SPRY4-IT1 as a promising indicator for three field lymph-node dissection of thoracic esophageal carcinoma
title_full Long non-coding RNA SPRY4-IT1 as a promising indicator for three field lymph-node dissection of thoracic esophageal carcinoma
title_fullStr Long non-coding RNA SPRY4-IT1 as a promising indicator for three field lymph-node dissection of thoracic esophageal carcinoma
title_full_unstemmed Long non-coding RNA SPRY4-IT1 as a promising indicator for three field lymph-node dissection of thoracic esophageal carcinoma
title_sort long non-coding rna spry4-it1 as a promising indicator for three field lymph-node dissection of thoracic esophageal carcinoma
publisher BMC
series Journal of Cardiothoracic Surgery
issn 1749-8090
publishDate 2021-03-01
description Abstract Background Esophageal squamous cell carcinoma(ESCC) is one of the most common tumors worldwide. Esophagectomy with three-field lymph node dissection(3FLND) is the radical surgical procedure for esophageal cancer. However, 3FLND is not widely used due to it’s higher mortality rate and higher incidence of postoperative complications. There is an urgent need to identify novel biomarkers that can guide the most proper lymph-node dissection in esophageal cancer patients. Method Ninety-two patients with thoracic ESCC undergoing 3FLND were enrolled into our study from the Department of Thoracic Surgery of the Fourth Hospital affiliated to the Hebei Medical University and Hebei General Hospital between Jun 2011 and Dec 2015. Retrospectively collected data from these 92 patients was used to explore the relationship between the lymph-node metastasis、recurrence and the SPRY4-IT1 expression level and to determine whether 3FLND should be performed in patients with thoracic ESCC. Results The findings revealed that the SPRY4-IT1 expression was significantly higher in esophageal cancer tissues than in adjacent noncancerous tissues. (P < 0.01). Furthermore, the high expression of SPRY4-IT1 was significantly correlated with tumor differentiation (P = 0.029), T classification (P = 0.013), lymph node metastasis(P = 0.022) and pathological stage (P = 0.001). The increased expression of SPRY4-IT1 was associated with a higher risk of cervical and superior mediastinal lymph-node metastasis(P = 0.039).However, no significant association was observed between the risk of cervical and superior mediastinal lymph-node recurrence and the SPRY4-IT1 expression level in the thoracic ESCC patients performed 3FLND(P = 0.509). Conclusions Our data support the assumption that the high expression of SPRY4-IT1 is associated with a high risk of lymph node metastasis and it has potential application as a indicator for guiding on three-field lymph node dissection in patients with thoracic ESCC. Randomized controlled trials with a large cohort of patients will be needed to confirm this conclusion in the future.
topic Esophageal carcinoma
SPRY4-IT1
Biomarker
Three field lymph-node dissection
url https://doi.org/10.1186/s13019-021-01433-x
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