Time-related morphometric studies of neurofilaments in brain contusions
In forensic pathology age determination of injuries is of key importance. The purpose of the study was to analyze morphometrically changes in neurofilaments following the brain contusion and relate them to the length of the time of survival. To do this, the authors analyzed specimens of brains colle...
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doaj-aabc0f3f072c467784af062e0af4d9592020-11-24T22:41:48ZengTermedia Publishing HouseFolia Neuropathologica1641-46401509-572X2016-03-01541505810.5114/fn.2016.5891527230Time-related morphometric studies of neurofilaments in brain contusionsMariusz KobekZbigniew JankowskiJanusz SzalaZbigniew Gąszczyk-OżarowskiArtur PałaszRafał SkowronekIn forensic pathology age determination of injuries is of key importance. The purpose of the study was to analyze morphometrically changes in neurofilaments following the brain contusion and relate them to the length of the time of survival. To do this, the authors analyzed specimens of brains collected during medicolegal autopsies. According to the available literature, no such study involving material from deceased humans was conducted. The researched material was divided into nine subgroups (10 cases each) according to the time of death of persons: immediately at the crime site, 12 hours, 24 hours, 2 days, 3 days, 4 days, 5 days, 6 days and 7 days after head trauma. Neurofilaments were immunohistochemically stained and evaluated quantitatively using the Met-Ilo computer application. The initial results were then analyzed statistically with the one way analysis of variance (ANOVA) and the least significant difference (LSD) tests. It was calculated that there are significant differences in numbers and area fractions of neurofilaments within 7 days after head trauma. It must be concluded that morphometric analysis of neurofilaments is a promising method but further studies are required.https://www.termedia.pl/Time-related-morphometric-studies-of-neurofilaments-in-brain-contusions,20,27230,1,1.html<i>brain contusion neurofilaments morphometry survival time</i> |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mariusz Kobek Zbigniew Jankowski Janusz Szala Zbigniew Gąszczyk-Ożarowski Artur Pałasz Rafał Skowronek |
spellingShingle |
Mariusz Kobek Zbigniew Jankowski Janusz Szala Zbigniew Gąszczyk-Ożarowski Artur Pałasz Rafał Skowronek Time-related morphometric studies of neurofilaments in brain contusions Folia Neuropathologica <i>brain contusion neurofilaments morphometry survival time</i> |
author_facet |
Mariusz Kobek Zbigniew Jankowski Janusz Szala Zbigniew Gąszczyk-Ożarowski Artur Pałasz Rafał Skowronek |
author_sort |
Mariusz Kobek |
title |
Time-related morphometric studies of neurofilaments in brain contusions |
title_short |
Time-related morphometric studies of neurofilaments in brain contusions |
title_full |
Time-related morphometric studies of neurofilaments in brain contusions |
title_fullStr |
Time-related morphometric studies of neurofilaments in brain contusions |
title_full_unstemmed |
Time-related morphometric studies of neurofilaments in brain contusions |
title_sort |
time-related morphometric studies of neurofilaments in brain contusions |
publisher |
Termedia Publishing House |
series |
Folia Neuropathologica |
issn |
1641-4640 1509-572X |
publishDate |
2016-03-01 |
description |
In forensic pathology age determination of injuries is of key importance. The purpose of the study was to analyze morphometrically changes in neurofilaments following the brain contusion and relate them to the length of the time of survival. To do this, the authors analyzed specimens of brains collected during medicolegal autopsies. According to the available literature, no such study involving material from deceased humans was conducted. The researched material was divided into nine subgroups (10 cases each) according to the time of death of persons: immediately at the crime site, 12 hours, 24 hours, 2 days, 3 days, 4 days, 5 days, 6 days and 7 days after head trauma. Neurofilaments were immunohistochemically stained and evaluated quantitatively using the Met-Ilo computer application. The initial results were then analyzed statistically with the one way analysis of variance (ANOVA) and the least significant difference (LSD) tests. It was calculated that there are significant differences in numbers and area fractions of neurofilaments within 7 days after head trauma. It must be concluded that morphometric analysis of neurofilaments is a promising method but further studies are required. |
topic |
<i>brain contusion neurofilaments morphometry survival time</i> |
url |
https://www.termedia.pl/Time-related-morphometric-studies-of-neurofilaments-in-brain-contusions,20,27230,1,1.html |
work_keys_str_mv |
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1725700751318056960 |