Modulating brain networks associated with cognitive deficits in Parkinson’s disease
Abstract Parkinson’s disease (PD) is a relatively well characterised neurological disorder that primarily affects motor and cognitive functions. This paper reviews on how transcranial direct current stimulation (tDCS) can be used to modulate brain networks associated with cognitive deficits in PD. W...
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doaj-aabf8ea6d76845d9a9ae277b306ac1912021-03-11T11:52:41ZengBMCMolecular Medicine1076-15511528-36582021-03-0127111110.1186/s10020-021-00284-5Modulating brain networks associated with cognitive deficits in Parkinson’s diseaseIman Beheshti0Ji Hyun Ko1Department of Human Anatomy and Cell Science, University of ManitobaDepartment of Human Anatomy and Cell Science, University of ManitobaAbstract Parkinson’s disease (PD) is a relatively well characterised neurological disorder that primarily affects motor and cognitive functions. This paper reviews on how transcranial direct current stimulation (tDCS) can be used to modulate brain networks associated with cognitive deficits in PD. We first provide an overview of brain network abnormalities in PD, by introducing the brain network modulation approaches such as pharmacological interventions and brain stimulation techniques. We then present the potential underlying mechanisms of tDCS technique, and specifically highlight how tDCS can be applied to modulate brain network abnormality associated with cognitive dysfunction among PD patients. More importantly, we address the limitations of existing studies and suggest possible future directions, with the aim of helping researchers to further develop the use of tDCS technique in clinical settings.https://doi.org/10.1186/s10020-021-00284-5Transcranial direct current stimulationParkinson’s diseaseCognitionPositron emission tomographyFunctional magnetic resonance imagingNetwork analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Iman Beheshti Ji Hyun Ko |
spellingShingle |
Iman Beheshti Ji Hyun Ko Modulating brain networks associated with cognitive deficits in Parkinson’s disease Molecular Medicine Transcranial direct current stimulation Parkinson’s disease Cognition Positron emission tomography Functional magnetic resonance imaging Network analysis |
author_facet |
Iman Beheshti Ji Hyun Ko |
author_sort |
Iman Beheshti |
title |
Modulating brain networks associated with cognitive deficits in Parkinson’s disease |
title_short |
Modulating brain networks associated with cognitive deficits in Parkinson’s disease |
title_full |
Modulating brain networks associated with cognitive deficits in Parkinson’s disease |
title_fullStr |
Modulating brain networks associated with cognitive deficits in Parkinson’s disease |
title_full_unstemmed |
Modulating brain networks associated with cognitive deficits in Parkinson’s disease |
title_sort |
modulating brain networks associated with cognitive deficits in parkinson’s disease |
publisher |
BMC |
series |
Molecular Medicine |
issn |
1076-1551 1528-3658 |
publishDate |
2021-03-01 |
description |
Abstract Parkinson’s disease (PD) is a relatively well characterised neurological disorder that primarily affects motor and cognitive functions. This paper reviews on how transcranial direct current stimulation (tDCS) can be used to modulate brain networks associated with cognitive deficits in PD. We first provide an overview of brain network abnormalities in PD, by introducing the brain network modulation approaches such as pharmacological interventions and brain stimulation techniques. We then present the potential underlying mechanisms of tDCS technique, and specifically highlight how tDCS can be applied to modulate brain network abnormality associated with cognitive dysfunction among PD patients. More importantly, we address the limitations of existing studies and suggest possible future directions, with the aim of helping researchers to further develop the use of tDCS technique in clinical settings. |
topic |
Transcranial direct current stimulation Parkinson’s disease Cognition Positron emission tomography Functional magnetic resonance imaging Network analysis |
url |
https://doi.org/10.1186/s10020-021-00284-5 |
work_keys_str_mv |
AT imanbeheshti modulatingbrainnetworksassociatedwithcognitivedeficitsinparkinsonsdisease AT jihyunko modulatingbrainnetworksassociatedwithcognitivedeficitsinparkinsonsdisease |
_version_ |
1724225100297797632 |