Modulating brain networks associated with cognitive deficits in Parkinson’s disease

• Main Authors: Iman Beheshti, Ji Hyun Ko
• Format: Article
• Language: English
• Published: BMC 2021-03-01
• Series: Molecular Medicine
• Subjects: Transcranial direct current stimulation; Parkinson’s disease; Cognition; Positron emission tomography; Functional magnetic resonance imaging; Network analysis
• Online Access: https://doi.org/10.1186/s10020-021-00284-5

Abstract Parkinson’s disease (PD) is a relatively well characterised neurological disorder that primarily affects motor and cognitive functions. This paper reviews on how transcranial direct current stimulation (tDCS) can be used to modulate brain networks associated with cognitive deficits in PD. We first provide an overview of brain network abnormalities in PD, by introducing the brain network modulation approaches such as pharmacological interventions and brain stimulation techniques. We then present the potential underlying mechanisms of tDCS technique, and specifically highlight how tDCS can be applied to modulate brain network abnormality associated with cognitive dysfunction among PD patients. More importantly, we address the limitations of existing studies and suggest possible future directions, with the aim of helping researchers to further develop the use of tDCS technique in clinical settings.