Design and In Vitro Evaluation of a New Nano-Microparticulate System for Enhanced Aqueous-Phase Solubility of Curcumin
Curcumin, a yellow polyphenol derived from the turmeric Curcuma longa, has been associated with a diverse therapeutic potential including anti-inflammatory, antioxidant, antiviral, and anticancer properties. However, the poor aqueous solubility and low bioavailability of curcumin have limited its po...
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doaj-aae0549b89894f5f81de7a15f8d398da2020-11-24T23:23:53ZengHindawi LimitedBioMed Research International2314-61332314-61412013-01-01201310.1155/2013/724763724763Design and In Vitro Evaluation of a New Nano-Microparticulate System for Enhanced Aqueous-Phase Solubility of CurcuminDiana Guzman-Villanueva0Ibrahim M. El-Sherbiny1Dea Herrera-Ruiz2Hugh D. C. Smyth3Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, TX 78712, USAPolymer Laboratory, Faculty of Science, Mansoura University, Mansoura 35516, EgyptFacultad de Farmacia, Universidad Autónoma del Estado de Morelos, 62209 Cuernavaca, MOR, MexicoDivision of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, TX 78712, USACurcumin, a yellow polyphenol derived from the turmeric Curcuma longa, has been associated with a diverse therapeutic potential including anti-inflammatory, antioxidant, antiviral, and anticancer properties. However, the poor aqueous solubility and low bioavailability of curcumin have limited its potential when administrated orally. In this study, curcumin was encapsulated in a series of novel nano-microparticulate systems developed to improve its aqueous solubility and stability. The nano-microparticulate systems are based entirely on biocompatible, biodegradable, and edible polymers including chitosan, alginate, and carrageenan. The particles were synthesized via ionotropic gelation. Encapsulating the curcumin into the hydrogel nanoparticles yielded a homogenous curcumin dispersion in aqueous solution compared to the free form of curcumin. Also, the in vitro release profile showed up to 95% release of curcumin from the developed nano-microparticulate systems after 9 hours in PBS at pH 7.4 when freeze-dried particles were used.http://dx.doi.org/10.1155/2013/724763 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Diana Guzman-Villanueva Ibrahim M. El-Sherbiny Dea Herrera-Ruiz Hugh D. C. Smyth |
spellingShingle |
Diana Guzman-Villanueva Ibrahim M. El-Sherbiny Dea Herrera-Ruiz Hugh D. C. Smyth Design and In Vitro Evaluation of a New Nano-Microparticulate System for Enhanced Aqueous-Phase Solubility of Curcumin BioMed Research International |
author_facet |
Diana Guzman-Villanueva Ibrahim M. El-Sherbiny Dea Herrera-Ruiz Hugh D. C. Smyth |
author_sort |
Diana Guzman-Villanueva |
title |
Design and In Vitro Evaluation of a New Nano-Microparticulate System for Enhanced Aqueous-Phase Solubility of Curcumin |
title_short |
Design and In Vitro Evaluation of a New Nano-Microparticulate System for Enhanced Aqueous-Phase Solubility of Curcumin |
title_full |
Design and In Vitro Evaluation of a New Nano-Microparticulate System for Enhanced Aqueous-Phase Solubility of Curcumin |
title_fullStr |
Design and In Vitro Evaluation of a New Nano-Microparticulate System for Enhanced Aqueous-Phase Solubility of Curcumin |
title_full_unstemmed |
Design and In Vitro Evaluation of a New Nano-Microparticulate System for Enhanced Aqueous-Phase Solubility of Curcumin |
title_sort |
design and in vitro evaluation of a new nano-microparticulate system for enhanced aqueous-phase solubility of curcumin |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2013-01-01 |
description |
Curcumin, a yellow polyphenol derived from the turmeric Curcuma longa, has been associated with a diverse therapeutic potential including anti-inflammatory, antioxidant, antiviral, and anticancer properties. However, the poor aqueous solubility and low bioavailability of curcumin have limited its potential when administrated orally. In this study, curcumin was encapsulated in a series of novel nano-microparticulate systems developed to improve its aqueous solubility and stability. The nano-microparticulate systems are based entirely on biocompatible, biodegradable, and edible polymers including chitosan, alginate, and carrageenan. The particles were synthesized via ionotropic gelation. Encapsulating the curcumin into the hydrogel nanoparticles yielded a homogenous curcumin dispersion in aqueous solution compared to the free form of curcumin. Also, the in vitro release profile showed up to 95% release of curcumin from the developed nano-microparticulate systems after 9 hours in PBS at pH 7.4 when freeze-dried particles were used. |
url |
http://dx.doi.org/10.1155/2013/724763 |
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