Real world data on follicular lymphoma patients treated by rituximab-containing immunochemotherapy and rituximab maintenance
Background/Aims Real-world data about the treatment outcomes of patients receiving rituximab-containing immunochemotherapy followed by rituximab maintenance are required to understand better the treatment for follicular lymphoma (FL). Methods A cross-sectional study analyzed FL patients who were tre...
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doaj-aae8c9dfc78145fbbb576b53efef235a2021-08-10T01:40:50ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482020-01-0135119420410.3904/kjim.2018.196170186Real world data on follicular lymphoma patients treated by rituximab-containing immunochemotherapy and rituximab maintenanceHee Kyung Kim0Wonseok Kang1Dong Hyun Sinn2Joon Hyeok Lee3Won Seog Kim4Seok Jin Kim5 Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaBackground/Aims Real-world data about the treatment outcomes of patients receiving rituximab-containing immunochemotherapy followed by rituximab maintenance are required to understand better the treatment for follicular lymphoma (FL). Methods A cross-sectional study analyzed FL patients who were treated with R-CVP (rituximab, cyclophosphamide, vincristine, and prednisone) or R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) and rituximab maintenance. Results Of 139 patients, 85 patients received R-CVP and 54 received R-CHOP. The characteristics did not differ significantly between the groups. Only grade 3 of FL was more common in R-CHOP. The complete response rate did not differ significantly between R-CHOP (50/54, 92.6%) and R-CVP (77/85, 90.6%). The number of disease relapses during rituximab maintenance did not differ significantly between the groups (p = 0.798). Therefore, the comparison of progression-free survival (PFS) showed no significant difference: the 3-year PFS rates for R-CVP and R-CHOP were 77% and 85%, respectively (p = 0.567). Although five of 56 hepatitis B virus (HBV) core antibody (anti-HBc)-positive patients experienced HBV reactivation, all cases of HBV reactivation were identified during regular monitoring for HBV DNA in blood, and were successfully managed with antiviral treatment. Conclusions The survival outcomes of FL patients on rituximab maintenance after responding to R-CVP or R-CHOP were similar. Rituximab-containing immunochemotherapy followed by rituximab maintenance can be safely used for anti-HBc-positive patients if HBV DNA titer in blood can be regularly monitored.http://www.kjim.org/upload/pdf/kjim-2018-196.pdflymphoma, follicularituximabhepatitis bimmunochemotherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hee Kyung Kim Wonseok Kang Dong Hyun Sinn Joon Hyeok Lee Won Seog Kim Seok Jin Kim |
spellingShingle |
Hee Kyung Kim Wonseok Kang Dong Hyun Sinn Joon Hyeok Lee Won Seog Kim Seok Jin Kim Real world data on follicular lymphoma patients treated by rituximab-containing immunochemotherapy and rituximab maintenance The Korean Journal of Internal Medicine lymphoma, follicula rituximab hepatitis b immunochemotherapy |
author_facet |
Hee Kyung Kim Wonseok Kang Dong Hyun Sinn Joon Hyeok Lee Won Seog Kim Seok Jin Kim |
author_sort |
Hee Kyung Kim |
title |
Real world data on follicular lymphoma patients treated by rituximab-containing immunochemotherapy and rituximab maintenance |
title_short |
Real world data on follicular lymphoma patients treated by rituximab-containing immunochemotherapy and rituximab maintenance |
title_full |
Real world data on follicular lymphoma patients treated by rituximab-containing immunochemotherapy and rituximab maintenance |
title_fullStr |
Real world data on follicular lymphoma patients treated by rituximab-containing immunochemotherapy and rituximab maintenance |
title_full_unstemmed |
Real world data on follicular lymphoma patients treated by rituximab-containing immunochemotherapy and rituximab maintenance |
title_sort |
real world data on follicular lymphoma patients treated by rituximab-containing immunochemotherapy and rituximab maintenance |
publisher |
The Korean Association of Internal Medicine |
series |
The Korean Journal of Internal Medicine |
issn |
1226-3303 2005-6648 |
publishDate |
2020-01-01 |
description |
Background/Aims Real-world data about the treatment outcomes of patients receiving rituximab-containing immunochemotherapy followed by rituximab maintenance are required to understand better the treatment for follicular lymphoma (FL). Methods A cross-sectional study analyzed FL patients who were treated with R-CVP (rituximab, cyclophosphamide, vincristine, and prednisone) or R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) and rituximab maintenance. Results Of 139 patients, 85 patients received R-CVP and 54 received R-CHOP. The characteristics did not differ significantly between the groups. Only grade 3 of FL was more common in R-CHOP. The complete response rate did not differ significantly between R-CHOP (50/54, 92.6%) and R-CVP (77/85, 90.6%). The number of disease relapses during rituximab maintenance did not differ significantly between the groups (p = 0.798). Therefore, the comparison of progression-free survival (PFS) showed no significant difference: the 3-year PFS rates for R-CVP and R-CHOP were 77% and 85%, respectively (p = 0.567). Although five of 56 hepatitis B virus (HBV) core antibody (anti-HBc)-positive patients experienced HBV reactivation, all cases of HBV reactivation were identified during regular monitoring for HBV DNA in blood, and were successfully managed with antiviral treatment. Conclusions The survival outcomes of FL patients on rituximab maintenance after responding to R-CVP or R-CHOP were similar. Rituximab-containing immunochemotherapy followed by rituximab maintenance can be safely used for anti-HBc-positive patients if HBV DNA titer in blood can be regularly monitored. |
topic |
lymphoma, follicula rituximab hepatitis b immunochemotherapy |
url |
http://www.kjim.org/upload/pdf/kjim-2018-196.pdf |
work_keys_str_mv |
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