The Prognostic Value of Nanog Overexpression in Lung Cancer: A Meta-Analysis
Background. Recent several studies have showed that the nanog overexpression leads to poor prognosis in some kinds of cancer including hepatocellular carcinoma and gastrointestinal luminal cancer. However, the correlations between prognosis and clinic-pathological features and nanog overexpression i...
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doaj-aaec1077e4e245eda0ee63208fb8814b2020-11-25T02:28:19ZengHindawi LimitedBioMed Research International2314-61332314-61412018-01-01201810.1155/2018/34292613429261The Prognostic Value of Nanog Overexpression in Lung Cancer: A Meta-AnalysisWei Cheng0Hongzhi Wang1Juanjuan Yuan2Ziwei Cheng3Dongwei Xing4Minguang Zhang5Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, ChinaCancer Hospital, Chinese Academy of Sciences, Hefei, Hefei, Anhui 230011, ChinaHefei Hospital Affiliated to Anhui Medical University/The Second People’s Hospital of Hefei, Hefei, Anhui 230011, ChinaShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, ChinaShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, ChinaShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, ChinaBackground. Recent several studies have showed that the nanog overexpression leads to poor prognosis in some kinds of cancer including hepatocellular carcinoma and gastrointestinal luminal cancer. However, the correlations between prognosis and clinic-pathological features and nanog overexpression in lung cancer are still not well-known. Thus, we performed a meta-analysis to evaluate the role of nanog in lung cancer. Methods. An electronic retrieval for related studies was conducted in PubMed, Cochrane Library, Web of Science, EMBASE databases, Chinese CNKI, and the Chinese Wan Fang database up to May 2018. The relationships between nanog overexpression and overall survival (OS) and disease-free survival (DFS) as well as clinic-pathological features in lung cancer were investigated. Pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by STATA12. Results. 11 studies containing 1422 patients were identified in our meta-analysis. The overexpression of nanog showed decreased OS (HR = 1.83, 95% CI = 1.49-2.25, P ≤ 0.001) and DFS (HR = 1.86, 95% CI = 1.2-2.9, P = 0.006). Moreover, overexpression of nanog was significantly related to differentiation (OR = 4.17, 95% CI = 2.17-6.43, P ≤ 0.001), lymph node metastasis (OR = 1.76, 95% CI = 1.06-2.91, P = 0.028) and tumor size (OR = 1.93, 95% CI = 1.17-3.20, P = 0.010), and no correlation with T stage, TNM, stage, and gender. Conclusions. Our results suggested that nanog overexpression, a hazard factor of differentiation, lymph node metastasis, and tumor size, may predicate decreased OS and DFS for lung cancer.http://dx.doi.org/10.1155/2018/3429261 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wei Cheng Hongzhi Wang Juanjuan Yuan Ziwei Cheng Dongwei Xing Minguang Zhang |
spellingShingle |
Wei Cheng Hongzhi Wang Juanjuan Yuan Ziwei Cheng Dongwei Xing Minguang Zhang The Prognostic Value of Nanog Overexpression in Lung Cancer: A Meta-Analysis BioMed Research International |
author_facet |
Wei Cheng Hongzhi Wang Juanjuan Yuan Ziwei Cheng Dongwei Xing Minguang Zhang |
author_sort |
Wei Cheng |
title |
The Prognostic Value of Nanog Overexpression in Lung Cancer: A Meta-Analysis |
title_short |
The Prognostic Value of Nanog Overexpression in Lung Cancer: A Meta-Analysis |
title_full |
The Prognostic Value of Nanog Overexpression in Lung Cancer: A Meta-Analysis |
title_fullStr |
The Prognostic Value of Nanog Overexpression in Lung Cancer: A Meta-Analysis |
title_full_unstemmed |
The Prognostic Value of Nanog Overexpression in Lung Cancer: A Meta-Analysis |
title_sort |
prognostic value of nanog overexpression in lung cancer: a meta-analysis |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2018-01-01 |
description |
Background. Recent several studies have showed that the nanog overexpression leads to poor prognosis in some kinds of cancer including hepatocellular carcinoma and gastrointestinal luminal cancer. However, the correlations between prognosis and clinic-pathological features and nanog overexpression in lung cancer are still not well-known. Thus, we performed a meta-analysis to evaluate the role of nanog in lung cancer. Methods. An electronic retrieval for related studies was conducted in PubMed, Cochrane Library, Web of Science, EMBASE databases, Chinese CNKI, and the Chinese Wan Fang database up to May 2018. The relationships between nanog overexpression and overall survival (OS) and disease-free survival (DFS) as well as clinic-pathological features in lung cancer were investigated. Pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by STATA12. Results. 11 studies containing 1422 patients were identified in our meta-analysis. The overexpression of nanog showed decreased OS (HR = 1.83, 95% CI = 1.49-2.25, P ≤ 0.001) and DFS (HR = 1.86, 95% CI = 1.2-2.9, P = 0.006). Moreover, overexpression of nanog was significantly related to differentiation (OR = 4.17, 95% CI = 2.17-6.43, P ≤ 0.001), lymph node metastasis (OR = 1.76, 95% CI = 1.06-2.91, P = 0.028) and tumor size (OR = 1.93, 95% CI = 1.17-3.20, P = 0.010), and no correlation with T stage, TNM, stage, and gender. Conclusions. Our results suggested that nanog overexpression, a hazard factor of differentiation, lymph node metastasis, and tumor size, may predicate decreased OS and DFS for lung cancer. |
url |
http://dx.doi.org/10.1155/2018/3429261 |
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