Diazoxide Protects against Myocardial Ischemia/Reperfusion Injury by Moderating ERS via Regulation of the miR-10a/IRE1 Pathway
Nowadays, reperfusion is still the most effective treatment for ischemic heart disease. However, cardiac reperfusion therapy would lead to reperfusion injury, which may have resulted from endoplasmic reticulum stress (ERS) during reperfusion. Diazoxide (DZ) is a highly selective mitochondrial adenos...
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Series: | Oxidative Medicine and Cellular Longevity |
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doaj-aaed3b1cfa8e4eaba41a6b907cff53302020-11-25T02:52:20ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942020-01-01202010.1155/2020/49572384957238Diazoxide Protects against Myocardial Ischemia/Reperfusion Injury by Moderating ERS via Regulation of the miR-10a/IRE1 PathwayLin Zhang0Shuang Cai1Song Cao2Jia Nie3Wenjing Zhou4Yu Zhang5Ke Li6Haiying Wang7Shouyang Yu8Tian Yu9Guizhou Key Laboratory of Anesthesia and Organ Protection, Affiliated Hospital of Zunyi Medical University, 563000 Zunyi, ChinaKey Laboratory of Brain Science, Zunyi Medical University, 563000 Zunyi, ChinaGuizhou Key Laboratory of Anesthesia and Organ Protection, Affiliated Hospital of Zunyi Medical University, 563000 Zunyi, ChinaDepartment of Anesthesiology, Affiliated Hospital of Zunyi Medical University, 563000 Zunyi, ChinaGuizhou Key Laboratory of Anesthesia and Organ Protection, Affiliated Hospital of Zunyi Medical University, 563000 Zunyi, ChinaGuizhou Key Laboratory of Anesthesia and Organ Protection, Affiliated Hospital of Zunyi Medical University, 563000 Zunyi, ChinaDepartment of Anesthesiology, Hospital of Stomatology, Zunyi Medical University, 563000 Zunyi, ChinaDepartment of Anesthesiology, Affiliated Hospital of Zunyi Medical University, 563000 Zunyi, ChinaGuizhou Key Laboratory of Anesthesia and Organ Protection, Affiliated Hospital of Zunyi Medical University, 563000 Zunyi, ChinaGuizhou Key Laboratory of Anesthesia and Organ Protection, Affiliated Hospital of Zunyi Medical University, 563000 Zunyi, ChinaNowadays, reperfusion is still the most effective treatment for ischemic heart disease. However, cardiac reperfusion therapy would lead to reperfusion injury, which may have resulted from endoplasmic reticulum stress (ERS) during reperfusion. Diazoxide (DZ) is a highly selective mitochondrial adenosine triphosphate-sensitive potassium channel opener. Its protective effect on I/R injury has been confirmed in many organs such as the heart and brain. However, the mechanism of its protective effect has not been fully elucidated. MicroRNAs (miRNAs) are widely involved in pathologies of heart disease. In this study, we found that miR-10a expression was highly upregulated in the myocardial I/R groups, and DZ treatment significantly reduced the expression of miR-10a. More importantly, we found that DZ treatment can moderate ERS via regulation of the miR-10a/IRE1 pathway in the I/R and H/R models, thereby protecting myocardial H/R injury.http://dx.doi.org/10.1155/2020/4957238 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lin Zhang Shuang Cai Song Cao Jia Nie Wenjing Zhou Yu Zhang Ke Li Haiying Wang Shouyang Yu Tian Yu |
spellingShingle |
Lin Zhang Shuang Cai Song Cao Jia Nie Wenjing Zhou Yu Zhang Ke Li Haiying Wang Shouyang Yu Tian Yu Diazoxide Protects against Myocardial Ischemia/Reperfusion Injury by Moderating ERS via Regulation of the miR-10a/IRE1 Pathway Oxidative Medicine and Cellular Longevity |
author_facet |
Lin Zhang Shuang Cai Song Cao Jia Nie Wenjing Zhou Yu Zhang Ke Li Haiying Wang Shouyang Yu Tian Yu |
author_sort |
Lin Zhang |
title |
Diazoxide Protects against Myocardial Ischemia/Reperfusion Injury by Moderating ERS via Regulation of the miR-10a/IRE1 Pathway |
title_short |
Diazoxide Protects against Myocardial Ischemia/Reperfusion Injury by Moderating ERS via Regulation of the miR-10a/IRE1 Pathway |
title_full |
Diazoxide Protects against Myocardial Ischemia/Reperfusion Injury by Moderating ERS via Regulation of the miR-10a/IRE1 Pathway |
title_fullStr |
Diazoxide Protects against Myocardial Ischemia/Reperfusion Injury by Moderating ERS via Regulation of the miR-10a/IRE1 Pathway |
title_full_unstemmed |
Diazoxide Protects against Myocardial Ischemia/Reperfusion Injury by Moderating ERS via Regulation of the miR-10a/IRE1 Pathway |
title_sort |
diazoxide protects against myocardial ischemia/reperfusion injury by moderating ers via regulation of the mir-10a/ire1 pathway |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0900 1942-0994 |
publishDate |
2020-01-01 |
description |
Nowadays, reperfusion is still the most effective treatment for ischemic heart disease. However, cardiac reperfusion therapy would lead to reperfusion injury, which may have resulted from endoplasmic reticulum stress (ERS) during reperfusion. Diazoxide (DZ) is a highly selective mitochondrial adenosine triphosphate-sensitive potassium channel opener. Its protective effect on I/R injury has been confirmed in many organs such as the heart and brain. However, the mechanism of its protective effect has not been fully elucidated. MicroRNAs (miRNAs) are widely involved in pathologies of heart disease. In this study, we found that miR-10a expression was highly upregulated in the myocardial I/R groups, and DZ treatment significantly reduced the expression of miR-10a. More importantly, we found that DZ treatment can moderate ERS via regulation of the miR-10a/IRE1 pathway in the I/R and H/R models, thereby protecting myocardial H/R injury. |
url |
http://dx.doi.org/10.1155/2020/4957238 |
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