A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patients
Background and objective: The association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and end-stage renal disease (ESRD) risk in IgA nephropathy (IgAN) patients is still controversial. A meta-analysis was performed to evaluate the association between ACE I/...
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2013-09-01
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Series: | Journal of the Renin-Angiotensin-Aldosterone System |
Online Access: | https://doi.org/10.1177/1470320312459978 |
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doaj-aafb00555176467e92b30392097135772021-05-02T19:10:40ZengHindawi - SAGE PublishingJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762013-09-011410.1177/1470320312459978A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patientsTian-Biao Zhou0Sheng-Sheng Yin1Rong Liang2Department of Pediatric Nephrology, The First Affiliated Hospital of Guangxi Medical University, ChinaCollege of Management, Guangxi University for Nationalities, ChinaDepartment of Pediatric-Neonatology, Baylor College of Medicine, USABackground and objective: The association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and end-stage renal disease (ESRD) risk in IgA nephropathy (IgAN) patients is still controversial. A meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and ESRD susceptibility in IgAN patients. Method: A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases. Results: Thirteen articles were identified for the analysis of the association between ACE I/D gene polymorphism and ESRD risk in IgAN patients. D allele and DD genotype were associated with ESRD susceptibility in IgAN patients for overall populations ( p =0.01 and 0.003, respectively). In Asians, there was a markedly positive association between DD genotype and ESRD susceptibility ( p =0.03). Furthermore, D allele and DD genotype were associated with ESRD susceptibility in Caucasians ( p =0.02 and 0.03, respectively). However, II genotype might not play a protective role against ESRD onset for overall populations, Asians and Caucasians. Conclusion: DD homozygote is a significant genetic molecular marker for the onset of ESRD in IgAN patients.https://doi.org/10.1177/1470320312459978 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tian-Biao Zhou Sheng-Sheng Yin Rong Liang |
spellingShingle |
Tian-Biao Zhou Sheng-Sheng Yin Rong Liang A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patients Journal of the Renin-Angiotensin-Aldosterone System |
author_facet |
Tian-Biao Zhou Sheng-Sheng Yin Rong Liang |
author_sort |
Tian-Biao Zhou |
title |
A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patients |
title_short |
A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patients |
title_full |
A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patients |
title_fullStr |
A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patients |
title_full_unstemmed |
A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patients |
title_sort |
meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in iga nephropathy patients |
publisher |
Hindawi - SAGE Publishing |
series |
Journal of the Renin-Angiotensin-Aldosterone System |
issn |
1470-3203 1752-8976 |
publishDate |
2013-09-01 |
description |
Background and objective: The association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and end-stage renal disease (ESRD) risk in IgA nephropathy (IgAN) patients is still controversial. A meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and ESRD susceptibility in IgAN patients. Method: A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases. Results: Thirteen articles were identified for the analysis of the association between ACE I/D gene polymorphism and ESRD risk in IgAN patients. D allele and DD genotype were associated with ESRD susceptibility in IgAN patients for overall populations ( p =0.01 and 0.003, respectively). In Asians, there was a markedly positive association between DD genotype and ESRD susceptibility ( p =0.03). Furthermore, D allele and DD genotype were associated with ESRD susceptibility in Caucasians ( p =0.02 and 0.03, respectively). However, II genotype might not play a protective role against ESRD onset for overall populations, Asians and Caucasians. Conclusion: DD homozygote is a significant genetic molecular marker for the onset of ESRD in IgAN patients. |
url |
https://doi.org/10.1177/1470320312459978 |
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