Emerging clinical significance of claudin-7 in colorectal cancer: a review
Kun Wang, Chang Xu, Wenjing Li, Lei Ding Department of Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, People’s Republic of China Abstract: Tight junctions (TJs) play an important role in maintaining cell polarity and regulating cell permeability. In recen...
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doaj-aafb406e321946a38c5c1012e01911f52020-11-24T22:03:02ZengDove Medical PressCancer Management and Research1179-13222018-09-01Volume 103741375240755Emerging clinical significance of claudin-7 in colorectal cancer: a reviewWang KXu CLi WJDing LKun Wang, Chang Xu, Wenjing Li, Lei Ding Department of Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, People’s Republic of China Abstract: Tight junctions (TJs) play an important role in maintaining cell polarity and regulating cell permeability. In recent years, many studies have shown that TJ proteins, especially claudin-7, are closely related to inflammation and the development of various malignant tumors. Claudin-7 plays a significant role in maintaining the physiological functions and pathological conditions of the TJ barrier. The dysregulation of claudin-7 plays a tumor suppressor role or conversely has carcinogenic effects in different target tissues or cells, but the exact underlying mechanism is still unclear. In this review, we will summarize the expression pattern of claudin-7 in tumors, focusing on the expression and regulation of claudin-7 in colorectal cancer and discussing the correlation between claudin-7 and invasion, metastasis and epithelial–mesenchymal transition (EMT) in colorectal cancer. The construction of Cldn7−/− mice and conventional claudin-7 knockout mouse models has helped determine the mechanisms by which claudin-7 promotes tumorigenesis. Elucidation of the expression and subcellular localization of claudin-7 under pathological conditions will help develop claudin-7 as a useful biomarker for detecting and diagnosing cancer, and thus may help combat the occurrence, development, and invasion of cancers. Keywords: tight junctions, claudin-7, tumors, colorectal cancer, invasion, metastasishttps://www.dovepress.com/emerging-clinical-significance-of-claudin-7-in-colorectal-cancer-a-rev-peer-reviewed-article-CMARtight junctionsclaudin-7tumorscolorectal cancerinvasionmetastasis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wang K Xu C Li WJ Ding L |
spellingShingle |
Wang K Xu C Li WJ Ding L Emerging clinical significance of claudin-7 in colorectal cancer: a review Cancer Management and Research tight junctions claudin-7 tumors colorectal cancer invasion metastasis |
author_facet |
Wang K Xu C Li WJ Ding L |
author_sort |
Wang K |
title |
Emerging clinical significance of claudin-7 in colorectal cancer: a review |
title_short |
Emerging clinical significance of claudin-7 in colorectal cancer: a review |
title_full |
Emerging clinical significance of claudin-7 in colorectal cancer: a review |
title_fullStr |
Emerging clinical significance of claudin-7 in colorectal cancer: a review |
title_full_unstemmed |
Emerging clinical significance of claudin-7 in colorectal cancer: a review |
title_sort |
emerging clinical significance of claudin-7 in colorectal cancer: a review |
publisher |
Dove Medical Press |
series |
Cancer Management and Research |
issn |
1179-1322 |
publishDate |
2018-09-01 |
description |
Kun Wang, Chang Xu, Wenjing Li, Lei Ding Department of Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, People’s Republic of China Abstract: Tight junctions (TJs) play an important role in maintaining cell polarity and regulating cell permeability. In recent years, many studies have shown that TJ proteins, especially claudin-7, are closely related to inflammation and the development of various malignant tumors. Claudin-7 plays a significant role in maintaining the physiological functions and pathological conditions of the TJ barrier. The dysregulation of claudin-7 plays a tumor suppressor role or conversely has carcinogenic effects in different target tissues or cells, but the exact underlying mechanism is still unclear. In this review, we will summarize the expression pattern of claudin-7 in tumors, focusing on the expression and regulation of claudin-7 in colorectal cancer and discussing the correlation between claudin-7 and invasion, metastasis and epithelial–mesenchymal transition (EMT) in colorectal cancer. The construction of Cldn7−/− mice and conventional claudin-7 knockout mouse models has helped determine the mechanisms by which claudin-7 promotes tumorigenesis. Elucidation of the expression and subcellular localization of claudin-7 under pathological conditions will help develop claudin-7 as a useful biomarker for detecting and diagnosing cancer, and thus may help combat the occurrence, development, and invasion of cancers. Keywords: tight junctions, claudin-7, tumors, colorectal cancer, invasion, metastasis |
topic |
tight junctions claudin-7 tumors colorectal cancer invasion metastasis |
url |
https://www.dovepress.com/emerging-clinical-significance-of-claudin-7-in-colorectal-cancer-a-rev-peer-reviewed-article-CMAR |
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