Analysis of HLA-A, HLA-B and HLA-DRB1 allelic frequencies in tertiary care from Telangana and Andhra Pradesh

• Main Authors: Radhika Chowdary, Sukrutha Gopal, Reddy, Prasad Reddy
• Format: Article
• Language: English
• Published: KIMS Foundation and Research Center 2014-06-01
• Series: Journal of Medical and Scientific Research
• Subjects: HLA-A; HLA-B; HLA-DRB1; allelic frequencies
• Online Access: http://jmsronline.com/article.aspx?ID=Analysis-of-HLA-A-HLA-B-HLA-DRB1-allelic-frequencies

Introduction: The high polymorphism of the HLA system and its typification is used as valuable tool in establishing association to various illnesses, immune and genetic profiles. It also provides a guide to identify compatibility among donor and recipient of organ transplants. Objective: To analyse HLA-A, HLA-B and HLA-DRB1 allelic frequencies among renal transplant recipients and their prospective related and unrelated donors attending Nephrology department at KIMS Hospital, Secunderabad. Methods: 146 kidney recipients and 154 related or unrelated donors coming from different regions of Telangana and Andhra Pradesh for kidney transplantation from September 2007 to December 2013 were included in this study. All were screened for HLA-A, B and DRB, via SSP PCR based methodology and allelic frequency was established. Result: 1738 and 17 different alleles were identified for HLA-A, B and DRB1 respectively. Alleles found more frequently are A*24, A*02, A*01, B*35, B*61, B*44 and DRB1*15, DRB1*04, DRB1*07. Conclusion: The results obtained are useful as a reference for organ transplantations and also for allowing compatible donors within specific area for patients requiring renal transplant.