Antibody-mediated targeting of cleavage-specific OPN-T cell interactions.
T cells are crucial players in obesity-mediated adipose tissue inflammation. We hypothesized that osteopontin (OPN), an inflammatory protein with enhanced activity when proteolytically cleaved, affects the number of viable T cells in adipose tissue and assessed inhibition of the interaction between...
Main Authors: | Bettina Wanko, Matteo Tardelli, Alexander Jürets, Angelika Neuhofer, Gerhard Prager, John Morser, Lawrence L Leung, Günther Staffler, Maximilian Zeyda, Thomas M Stulnig |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2019-01-01
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Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0214938 |
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