A whole-genome sequence and transcriptome perspective on HER2-positive breast cancers
Breast cancer is separated into multiple subtypes based on the expression of HER2 and hormone receptors. Here, the authors report the whole genome sequence of 64 HER2 positive tumours and show that these can be further separated into four groups with different gene expression profiles and genomic fe...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2016-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12222 |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Anthony Ferrari Anne Vincent-Salomon Xavier Pivot Anne-Sophie Sertier Emilie Thomas Laurie Tonon Sandrine Boyault Eskeatnaf Mulugeta Isabelle Treilleux Gaëtan MacGrogan Laurent Arnould Janice Kielbassa Vincent Le Texier Hélène Blanché Jean-François Deleuze Jocelyne Jacquemier Marie-Christine Mathieu Frédérique Penault-Llorca Frédéric Bibeau Odette Mariani Cécile Mannina Jean-Yves Pierga Olivier Trédan Thomas Bachelot Hervé Bonnefoi Gilles Romieu Pierre Fumoleau Suzette Delaloge Maria Rios Jean-Marc Ferrero Carole Tarpin Catherine Bouteille Fabien Calvo Ivo Glynne Gut Marta Gut Sancha Martin Serena Nik-Zainal Michael R. Stratton Iris Pauporté Pierre Saintigny Daniel Birnbaum Alain Viari Gilles Thomas |
| spellingShingle |
Anthony Ferrari Anne Vincent-Salomon Xavier Pivot Anne-Sophie Sertier Emilie Thomas Laurie Tonon Sandrine Boyault Eskeatnaf Mulugeta Isabelle Treilleux Gaëtan MacGrogan Laurent Arnould Janice Kielbassa Vincent Le Texier Hélène Blanché Jean-François Deleuze Jocelyne Jacquemier Marie-Christine Mathieu Frédérique Penault-Llorca Frédéric Bibeau Odette Mariani Cécile Mannina Jean-Yves Pierga Olivier Trédan Thomas Bachelot Hervé Bonnefoi Gilles Romieu Pierre Fumoleau Suzette Delaloge Maria Rios Jean-Marc Ferrero Carole Tarpin Catherine Bouteille Fabien Calvo Ivo Glynne Gut Marta Gut Sancha Martin Serena Nik-Zainal Michael R. Stratton Iris Pauporté Pierre Saintigny Daniel Birnbaum Alain Viari Gilles Thomas A whole-genome sequence and transcriptome perspective on HER2-positive breast cancers Nature Communications |
| author_facet |
Anthony Ferrari Anne Vincent-Salomon Xavier Pivot Anne-Sophie Sertier Emilie Thomas Laurie Tonon Sandrine Boyault Eskeatnaf Mulugeta Isabelle Treilleux Gaëtan MacGrogan Laurent Arnould Janice Kielbassa Vincent Le Texier Hélène Blanché Jean-François Deleuze Jocelyne Jacquemier Marie-Christine Mathieu Frédérique Penault-Llorca Frédéric Bibeau Odette Mariani Cécile Mannina Jean-Yves Pierga Olivier Trédan Thomas Bachelot Hervé Bonnefoi Gilles Romieu Pierre Fumoleau Suzette Delaloge Maria Rios Jean-Marc Ferrero Carole Tarpin Catherine Bouteille Fabien Calvo Ivo Glynne Gut Marta Gut Sancha Martin Serena Nik-Zainal Michael R. Stratton Iris Pauporté Pierre Saintigny Daniel Birnbaum Alain Viari Gilles Thomas |
| author_sort |
Anthony Ferrari |
| title |
A whole-genome sequence and transcriptome perspective on HER2-positive breast cancers |
| title_short |
A whole-genome sequence and transcriptome perspective on HER2-positive breast cancers |
| title_full |
A whole-genome sequence and transcriptome perspective on HER2-positive breast cancers |
| title_fullStr |
A whole-genome sequence and transcriptome perspective on HER2-positive breast cancers |
| title_full_unstemmed |
A whole-genome sequence and transcriptome perspective on HER2-positive breast cancers |
| title_sort |
whole-genome sequence and transcriptome perspective on her2-positive breast cancers |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-07-01 |
| description |
Breast cancer is separated into multiple subtypes based on the expression of HER2 and hormone receptors. Here, the authors report the whole genome sequence of 64 HER2 positive tumours and show that these can be further separated into four groups with different gene expression profiles and genomic features. |
| url |
https://doi.org/10.1038/ncomms12222 |
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doaj-ab0d2ca4b11b4f8888dd3d70ad443efe2021-05-11T11:02:05ZengNature Publishing GroupNature Communications2041-17232016-07-01711910.1038/ncomms12222A whole-genome sequence and transcriptome perspective on HER2-positive breast cancersAnthony Ferrari0Anne Vincent-Salomon1Xavier Pivot2Anne-Sophie Sertier3Emilie Thomas4Laurie Tonon5Sandrine Boyault6Eskeatnaf Mulugeta7Isabelle Treilleux8Gaëtan MacGrogan9Laurent Arnould10Janice Kielbassa11Vincent Le Texier12Hélène Blanché13Jean-François Deleuze14Jocelyne Jacquemier15Marie-Christine Mathieu16Frédérique Penault-Llorca17Frédéric Bibeau18Odette Mariani19Cécile Mannina20Jean-Yves Pierga21Olivier Trédan22Thomas Bachelot23Hervé Bonnefoi24Gilles Romieu25Pierre Fumoleau26Suzette Delaloge27Maria Rios28Jean-Marc Ferrero29Carole Tarpin30Catherine Bouteille31Fabien Calvo32Ivo Glynne Gut33Marta Gut34Sancha Martin35Serena Nik-Zainal36Michael R. Stratton37Iris Pauporté38Pierre Saintigny39Daniel Birnbaum40Alain Viari41Gilles Thomas42Synergie Lyon Cancer, Plateforme de bioinformatique ‘Gilles Thomas’ Centre Léon BérardDépartement de Pathologie, Institut Curie, PSL Research UniversityCentre Hospitalier Universitaire de MinjozSynergie Lyon Cancer, Plateforme de bioinformatique ‘Gilles Thomas’ Centre Léon BérardSynergie Lyon Cancer, Plateforme de bioinformatique ‘Gilles Thomas’ Centre Léon BérardSynergie Lyon Cancer, Plateforme de bioinformatique ‘Gilles Thomas’ Centre Léon BérardPlateforme de génomique des cancers, Centre Léon BérardInstitut Curie, UMR 3215 CNRS, Génétique et biologie du développement, Epigénèse et développement des mammifèresDépartement de Pathologie, Centre Léon BérardDépartement de Biopathologie, Unité Inserm U916, Institut BergoniéCentre Georges-François Leclerc et CRB Ferdinand CabanneSynergie Lyon Cancer, Plateforme de bioinformatique ‘Gilles Thomas’ Centre Léon BérardSynergie Lyon Cancer, Plateforme de bioinformatique ‘Gilles Thomas’ Centre Léon BérardCentre d'Etude du Polymorphisme Humain (CEPH), Fondation Jean DaussetCentre d'Etude du Polymorphisme Humain (CEPH), Fondation Jean DaussetDépartement de Pathologie, Institut Paoli-CalmettesInstitut Gustave Roussy, Comité de Pathologie MammaireDépartement de Biopathologie, Centre Jean Perrin, EA 4677 ERTICa, Université d'AuvergneDépartement de Pathologie, Institut Régional du Cancer de Montpellier (ICM)Institut Curie, PSL Research University, Service de Pathologie, Centre de Ressources BiologiquesDépartement de Pathologie, Institut BergoniéDépartement d'Oncologie Médicale, Institut Curie, PSL Research University, Université Paris DescartesDépartement de Cancérologie Médicale, Centre Léon BérardDépartement de Cancérologie Médicale, Centre Léon BérardDepartment of Medical Oncology, Institut Bergonié Unicancer, University of BordeauxInstitut Régional du Cancer de Montpellier (ICM), Oncologie SénologieCentre Georges-François Leclerc et CRB Ferdinand CabanneInstitut Gustave Roussy, Comité de Pathologie MammaireDépartement d’Oncologie Médicale, Centre Alexis VautrinDépartement d'Oncologie Médicale, Centre Antoine LacassagneDépartement d’Oncologie Médicale, Institut Paoli-CalmettesClinique Mutualiste de Bellevue, Chirurgie Gynécologique et MammaireInstitut Gustave Roussy, Cancer Core EuropeCNAG-CRG, Centre for Genomic Regulation (CRG)CNAG-CRG, Centre for Genomic Regulation (CRG)Wellcome Trust Sanger InstituteWellcome Trust Sanger InstituteWellcome Trust Sanger InstituteDépartement de Recherche Clinique, Institut National du CancerINSERM U1052-CNRS 5286, Cancer Research Center of LyonDépartement d’Oncologie Moléculaire, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de MarseilleSynergie Lyon Cancer, Plateforme de bioinformatique ‘Gilles Thomas’ Centre Léon BérardSynergie Lyon Cancer, Plateforme de bioinformatique ‘Gilles Thomas’ Centre Léon BérardBreast cancer is separated into multiple subtypes based on the expression of HER2 and hormone receptors. Here, the authors report the whole genome sequence of 64 HER2 positive tumours and show that these can be further separated into four groups with different gene expression profiles and genomic features.https://doi.org/10.1038/ncomms12222 |