Toripalimab-Induced Dermatomyositis in a Patient with Metastatic Melanoma

• Main Authors: Jingrong Lin, Minmin Xue, Mingyang Gao, Pu Yu, Shixin Han
• Format: Article
• Language: English
• Published: Adis, Springer Healthcare 2020-05-01
• Series: Dermatology and Therapy
• Subjects: Dermatomyositis; irAEs; Metastatic melanoma; Toripalimab; Treatment
• Online Access: https://doi.org/10.1007/s13555-020-00396-6

Abstract Toripalimab is a monoclonal antibody targeting programmed cell death protein 1 (PD-1). It has recently been approved as an immune checkpoint inhibitor in second-line therapies in patients with unresectable or metastatic melanoma; however, it may be associated with various immune-related adverse events (irAEs). Here we report a case of toripalimab-induced dermatomyositis in a patient receiving treatment for metastatic melanoma. The symptoms were relieved by discontinuing toripalimab and administering once-daily intravenous methylprednisolone 1 mg/kg. We suggest that this case serves a warning to clinicians of the need to be aware of the possiblilty of toripalimab-induced dermatomyositis. Early recognition and treatment may prevent progression and improve prognosis of this irAE.