Effect of α-lipoic acid on the removal of arsenic from arsenic-loaded isolated liver tissues of rat
The patient of chronic arsenic toxicity shows oxidative stress. To overcome the oxidative stress, several antioxidants such as beta-carotene, ascorbic acid, α-tocopherol, zinc and selenium had been suggested in the treatment of chronic arsenic toxicity. In the present study universal antioxidant (bo...
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doaj-ab12a5ecf6fc4fc7876d04ffaf6414e12020-11-25T03:26:43ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-007X1991-00882006-03-01112732 Effect of α-lipoic acid on the removal of arsenic from arsenic-loaded isolated liver tissues of ratNoor E-TabassumThe patient of chronic arsenic toxicity shows oxidative stress. To overcome the oxidative stress, several antioxidants such as beta-carotene, ascorbic acid, α-tocopherol, zinc and selenium had been suggested in the treatment of chronic arsenic toxicity. In the present study universal antioxidant (both water and lipid soluble antioxidant) α-lipoic acid was used to examine the effectiveness of reducing the amount of arsenic from arsenic-loaded isolated liver tissues of rat. Isolated liver tissues of Long Evans Norwegian rats were cut into small pieces and incubated first in presence or absence of arsenic and then with different concentrations of α-lipoic acid during the second incubation. α-Lipoic acid decreases the amount of arsenic and malondialdehyde (MDA) in liver tissues as well as increases the reduced glutathione (GSH) level in dose dependent manner. These results suggest that α-lipoic acid remove arsenic from arsenic-loaded isolated liver tissues of rat.http://banglajol.info/index.php/BJP/article/view/484ArsenicIsolated liver tissuesα-lipoic acid |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Noor E-Tabassum |
spellingShingle |
Noor E-Tabassum Effect of α-lipoic acid on the removal of arsenic from arsenic-loaded isolated liver tissues of rat Bangladesh Journal of Pharmacology Arsenic Isolated liver tissues α-lipoic acid |
author_facet |
Noor E-Tabassum |
author_sort |
Noor E-Tabassum |
title |
Effect of α-lipoic acid on the removal of arsenic from arsenic-loaded isolated liver tissues of rat |
title_short |
Effect of α-lipoic acid on the removal of arsenic from arsenic-loaded isolated liver tissues of rat |
title_full |
Effect of α-lipoic acid on the removal of arsenic from arsenic-loaded isolated liver tissues of rat |
title_fullStr |
Effect of α-lipoic acid on the removal of arsenic from arsenic-loaded isolated liver tissues of rat |
title_full_unstemmed |
Effect of α-lipoic acid on the removal of arsenic from arsenic-loaded isolated liver tissues of rat |
title_sort |
effect of α-lipoic acid on the removal of arsenic from arsenic-loaded isolated liver tissues of rat |
publisher |
Bangladesh Pharmacological Society |
series |
Bangladesh Journal of Pharmacology |
issn |
1991-007X 1991-0088 |
publishDate |
2006-03-01 |
description |
The patient of chronic arsenic toxicity shows oxidative stress. To overcome the oxidative stress, several antioxidants such as beta-carotene, ascorbic acid, α-tocopherol, zinc and selenium had been suggested in the treatment of chronic arsenic toxicity. In the present study universal antioxidant (both water and lipid soluble antioxidant) α-lipoic acid was used to examine the effectiveness of reducing the amount of arsenic from arsenic-loaded isolated liver tissues of rat. Isolated liver tissues of Long Evans Norwegian rats were cut into small pieces and incubated first in presence or absence of arsenic and then with different concentrations of α-lipoic acid during the second incubation. α-Lipoic acid decreases the amount of arsenic and malondialdehyde (MDA) in liver tissues as well as increases the reduced glutathione (GSH) level in dose dependent manner. These results suggest that α-lipoic acid remove arsenic from arsenic-loaded isolated liver tissues of rat. |
topic |
Arsenic Isolated liver tissues α-lipoic acid |
url |
http://banglajol.info/index.php/BJP/article/view/484 |
work_keys_str_mv |
AT nooretabassum effectofalipoicacidontheremovalofarsenicfromarsenicloadedisolatedlivertissuesofrat |
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