Plasma levels of procalcitonin and eight additional inflammatory molecules in febrile neutropenic patients
OBJECTIVE: This study aimed to examine the association between different inflammatory markers and specific clinical endpoints in patients with febrile neutropenia. METHOD: We prospectively evaluated the expression of procalcitonin (PCT), interleukin 8 (IL-8), induced protein-10, tumor necrosis facto...
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Faculdade de Medicina / USP
2011-01-01
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doaj-ab2a39ffc64b4e7d88ac3d22ea88c6212020-11-24T23:48:44ZengFaculdade de Medicina / USPClinics1807-59321980-53222011-01-0166101699170510.1590/S1807-59322011001000006Plasma levels of procalcitonin and eight additional inflammatory molecules in febrile neutropenic patientsLetícia Carvalho NeuenschwanderHenrique BittencourtAna Flávia Tibúrcio RibeiroAntônio Lúcio TeixeiraMauro M. TeixeiraJairo Cerqueira TeixeiraVandack NobreOBJECTIVE: This study aimed to examine the association between different inflammatory markers and specific clinical endpoints in patients with febrile neutropenia. METHOD: We prospectively evaluated the expression of procalcitonin (PCT), interleukin 8 (IL-8), induced protein-10, tumor necrosis factor alpha (TNF-a), two soluble TNF-a receptors (sTNF-R I and sTNF-R II), monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1 alpha, and eotaxin in 37 episodes of febrile neutropenia occurring in 31 hospitalized adult onco-hematologic patients. Peripheral blood samples were collected in the morning at inclusion (day of fever onset) and on days 1, 3, and 7 after the onset of fever. Approximately 2-3 ml of plasma was obtained from each blood sample and stored at -80°C. RESULTS: The sTNF-R II level at inclusion (day 1), the PCT level on the day of fever onset, and the change (day 3 - day 1) in the IL-8 and eotaxin levels were significantly higher in patients who died during the 28-day follow-up. A requirement for early adjustment of antimicrobial treatment was associated with higher day 3 levels of IL-8, sTNF-R II, PCT, and MCP-1. CONCLUSION: Procalcitonin, sTNF-R II, IL-8, MCP-1, and eotaxin could potentially be used to assess the risk of death and the requirement for early adjustment of antimicrobial treatment in febrile, neutropenic onco-hematologic patients. The levels of the other markers showed no association with any of the evaluated endpoints.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011001000006Febrile neutropeniaInflammatory markersProcalcitoninSensitivitySpecificity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Letícia Carvalho Neuenschwander Henrique Bittencourt Ana Flávia Tibúrcio Ribeiro Antônio Lúcio Teixeira Mauro M. Teixeira Jairo Cerqueira Teixeira Vandack Nobre |
spellingShingle |
Letícia Carvalho Neuenschwander Henrique Bittencourt Ana Flávia Tibúrcio Ribeiro Antônio Lúcio Teixeira Mauro M. Teixeira Jairo Cerqueira Teixeira Vandack Nobre Plasma levels of procalcitonin and eight additional inflammatory molecules in febrile neutropenic patients Clinics Febrile neutropenia Inflammatory markers Procalcitonin Sensitivity Specificity |
author_facet |
Letícia Carvalho Neuenschwander Henrique Bittencourt Ana Flávia Tibúrcio Ribeiro Antônio Lúcio Teixeira Mauro M. Teixeira Jairo Cerqueira Teixeira Vandack Nobre |
author_sort |
Letícia Carvalho Neuenschwander |
title |
Plasma levels of procalcitonin and eight additional inflammatory molecules in febrile neutropenic patients |
title_short |
Plasma levels of procalcitonin and eight additional inflammatory molecules in febrile neutropenic patients |
title_full |
Plasma levels of procalcitonin and eight additional inflammatory molecules in febrile neutropenic patients |
title_fullStr |
Plasma levels of procalcitonin and eight additional inflammatory molecules in febrile neutropenic patients |
title_full_unstemmed |
Plasma levels of procalcitonin and eight additional inflammatory molecules in febrile neutropenic patients |
title_sort |
plasma levels of procalcitonin and eight additional inflammatory molecules in febrile neutropenic patients |
publisher |
Faculdade de Medicina / USP |
series |
Clinics |
issn |
1807-5932 1980-5322 |
publishDate |
2011-01-01 |
description |
OBJECTIVE: This study aimed to examine the association between different inflammatory markers and specific clinical endpoints in patients with febrile neutropenia. METHOD: We prospectively evaluated the expression of procalcitonin (PCT), interleukin 8 (IL-8), induced protein-10, tumor necrosis factor alpha (TNF-a), two soluble TNF-a receptors (sTNF-R I and sTNF-R II), monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1 alpha, and eotaxin in 37 episodes of febrile neutropenia occurring in 31 hospitalized adult onco-hematologic patients. Peripheral blood samples were collected in the morning at inclusion (day of fever onset) and on days 1, 3, and 7 after the onset of fever. Approximately 2-3 ml of plasma was obtained from each blood sample and stored at -80°C. RESULTS: The sTNF-R II level at inclusion (day 1), the PCT level on the day of fever onset, and the change (day 3 - day 1) in the IL-8 and eotaxin levels were significantly higher in patients who died during the 28-day follow-up. A requirement for early adjustment of antimicrobial treatment was associated with higher day 3 levels of IL-8, sTNF-R II, PCT, and MCP-1. CONCLUSION: Procalcitonin, sTNF-R II, IL-8, MCP-1, and eotaxin could potentially be used to assess the risk of death and the requirement for early adjustment of antimicrobial treatment in febrile, neutropenic onco-hematologic patients. The levels of the other markers showed no association with any of the evaluated endpoints. |
topic |
Febrile neutropenia Inflammatory markers Procalcitonin Sensitivity Specificity |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011001000006 |
work_keys_str_mv |
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