Metoclopramide neurological side effects screening; a pharmacovigilence study in Romanian community pharmacies
Background. Metoclopramide is a pharmacological agent frequently used in therapy against nausea and vomiting that can occur in indigestion, motion sickness, gastric ulcer, pyloric spasm and after surgery as a side effect of some anesthetics. Knowing the frequency and intensity of metoclopramide neur...
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Ion Motofei, Carol Davila University
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doaj-ab32cec1006f494f88c61ed993a4697d2020-11-25T03:35:57ZengIon Motofei, Carol Davila UniversityJournal of Mind and Medical Sciences2392-76742015-04-01215566Metoclopramide neurological side effects screening; a pharmacovigilence study in Romanian community pharmaciesEmil Ștefănescu0Mihaela Pleșu1Corina Scutari2Adrian Junghină3Horațiu Mireșan4Carol Davila University of Medicine and Pharmacy, Department of Pharmacology and Clinical PharmacyEmergency Clinical Hospital of Constanța, Department of PharmacyNicolae Testemițanu State University of Medicine and Pharmacy, Department of Pharmacology/ Clinical PharmacyMedico Farmaceutic Denyro Ltd – BucharestOvidius University of Medicine and Pharmacy, Department of ToxicologyBackground. Metoclopramide is a pharmacological agent frequently used in therapy against nausea and vomiting that can occur in indigestion, motion sickness, gastric ulcer, pyloric spasm and after surgery as a side effect of some anesthetics. Knowing the frequency and intensity of metoclopramide neurological side effects is essential for an efficient management of the dysfunctions it addresses. Material and method. Based on a standard questionnaire containing questions regarding metoclopramide therapy, we analyzed the answers given by 1000 patients or patient tutors in 20 open circuit pharmacies situated all over Bucharest. All subjects freely consented to participate in this study that was coordinated only by pharmacists. Results. Our study highlights the fact that in certain situations having to do with the age of patients, with the use of multiple drugs or with the tendency to self medicate, the neurological side effects of metoclopramide can reach dangerous levels. In some cases it might even be necessary to immediately interrupt metoclopramide therapy, despite its positive benefit/ risk ratio. Conclusions. Respecting the physician’s recommendations, avoiding self medication and reporting side effects as quickly as possible, are essential elements for minimizing the consequences of metoclopramide side effects. http://www.jmms.ro/download_counter/viewer.php?id=61metoclopramideneurological side effectspharmacovigilence |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Emil Ștefănescu Mihaela Pleșu Corina Scutari Adrian Junghină Horațiu Mireșan |
spellingShingle |
Emil Ștefănescu Mihaela Pleșu Corina Scutari Adrian Junghină Horațiu Mireșan Metoclopramide neurological side effects screening; a pharmacovigilence study in Romanian community pharmacies Journal of Mind and Medical Sciences metoclopramide neurological side effects pharmacovigilence |
author_facet |
Emil Ștefănescu Mihaela Pleșu Corina Scutari Adrian Junghină Horațiu Mireșan |
author_sort |
Emil Ștefănescu |
title |
Metoclopramide neurological side effects screening; a pharmacovigilence study in Romanian community pharmacies |
title_short |
Metoclopramide neurological side effects screening; a pharmacovigilence study in Romanian community pharmacies |
title_full |
Metoclopramide neurological side effects screening; a pharmacovigilence study in Romanian community pharmacies |
title_fullStr |
Metoclopramide neurological side effects screening; a pharmacovigilence study in Romanian community pharmacies |
title_full_unstemmed |
Metoclopramide neurological side effects screening; a pharmacovigilence study in Romanian community pharmacies |
title_sort |
metoclopramide neurological side effects screening; a pharmacovigilence study in romanian community pharmacies |
publisher |
Ion Motofei, Carol Davila University |
series |
Journal of Mind and Medical Sciences |
issn |
2392-7674 |
publishDate |
2015-04-01 |
description |
Background. Metoclopramide is a pharmacological agent frequently used in therapy against nausea and vomiting that can occur in indigestion, motion sickness, gastric ulcer, pyloric spasm and after surgery as a side effect of some anesthetics. Knowing the frequency and intensity of metoclopramide neurological side effects is essential for an efficient management of the dysfunctions it addresses.
Material and method. Based on a standard questionnaire containing questions regarding metoclopramide therapy, we analyzed the answers given by 1000 patients or patient tutors in 20 open circuit pharmacies situated all over Bucharest. All subjects freely consented to participate in this study that was coordinated only by pharmacists.
Results. Our study highlights the fact that in certain situations having to do with the age of patients, with the use of multiple drugs or with the tendency to self medicate, the neurological side effects of metoclopramide can reach dangerous levels. In some cases it might even be necessary to immediately interrupt metoclopramide therapy, despite its positive benefit/ risk ratio.
Conclusions. Respecting the physician’s recommendations, avoiding self medication and reporting side effects as quickly as possible, are essential elements for minimizing the consequences of metoclopramide side effects. |
topic |
metoclopramide neurological side effects pharmacovigilence |
url |
http://www.jmms.ro/download_counter/viewer.php?id=61 |
work_keys_str_mv |
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