Platelet Endothelial Cell Adhesion Molecule-1 and Oligodendrogenesis: Significance in Alcohol Use Disorders
Alcoholism is a chronic relapsing disorder with few therapeutic strategies that address the core pathophysiology. Brain tissue loss and oxidative damage are key components of alcoholism, such that reversal of these phenomena may help break the addictive cycle in alcohol use disorder (AUD). The curre...
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doaj-ab344b6ee9b7484b866bde5433645ab62020-11-24T23:55:15ZengMDPI AGBrain Sciences2076-34252017-10-0171013110.3390/brainsci7100131brainsci7100131Platelet Endothelial Cell Adhesion Molecule-1 and Oligodendrogenesis: Significance in Alcohol Use DisordersChitra D. Mandyam0Emmanuel G. Villalpando1Noah L. Steiner2Leon W. Quach3McKenzie J. Fannon4Sucharita S. Somkuwar5VA San Diego Healthcare System, San Diego, CA 92161, USAVA San Diego Healthcare System, San Diego, CA 92161, USAVA San Diego Healthcare System, San Diego, CA 92161, USAVA San Diego Healthcare System, San Diego, CA 92161, USAVA San Diego Healthcare System, San Diego, CA 92161, USAVA San Diego Healthcare System, San Diego, CA 92161, USAAlcoholism is a chronic relapsing disorder with few therapeutic strategies that address the core pathophysiology. Brain tissue loss and oxidative damage are key components of alcoholism, such that reversal of these phenomena may help break the addictive cycle in alcohol use disorder (AUD). The current review focuses on platelet endothelial cell adhesion molecule 1 (PECAM-1), a key modulator of the cerebral endothelial integrity and neuroinflammation, and a targetable transmembrane protein whose interaction within AUD has not been well explored. The current review will elaborate on the function of PECAM-1 in physiology and pathology and infer its contribution in AUD neuropathology. Recent research reveals that oligodendrocytes, whose primary function is myelination of neurons in the brain, are a key component in new learning and adaptation to environmental challenges. The current review briefly introduces the role of oligodendrocytes in healthy physiology and neuropathology. Importantly, we will highlight the recent evidence of dysregulation of oligodendrocytes in the context of AUD and then discuss their potential interaction with PECAM-1 on the cerebral endothelium.https://www.mdpi.com/2076-3425/7/10/131alcoholblood–brain barrierendotheliumPECAM-1oligodendrogliamyelin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chitra D. Mandyam Emmanuel G. Villalpando Noah L. Steiner Leon W. Quach McKenzie J. Fannon Sucharita S. Somkuwar |
spellingShingle |
Chitra D. Mandyam Emmanuel G. Villalpando Noah L. Steiner Leon W. Quach McKenzie J. Fannon Sucharita S. Somkuwar Platelet Endothelial Cell Adhesion Molecule-1 and Oligodendrogenesis: Significance in Alcohol Use Disorders Brain Sciences alcohol blood–brain barrier endothelium PECAM-1 oligodendroglia myelin |
author_facet |
Chitra D. Mandyam Emmanuel G. Villalpando Noah L. Steiner Leon W. Quach McKenzie J. Fannon Sucharita S. Somkuwar |
author_sort |
Chitra D. Mandyam |
title |
Platelet Endothelial Cell Adhesion Molecule-1 and Oligodendrogenesis: Significance in Alcohol Use Disorders |
title_short |
Platelet Endothelial Cell Adhesion Molecule-1 and Oligodendrogenesis: Significance in Alcohol Use Disorders |
title_full |
Platelet Endothelial Cell Adhesion Molecule-1 and Oligodendrogenesis: Significance in Alcohol Use Disorders |
title_fullStr |
Platelet Endothelial Cell Adhesion Molecule-1 and Oligodendrogenesis: Significance in Alcohol Use Disorders |
title_full_unstemmed |
Platelet Endothelial Cell Adhesion Molecule-1 and Oligodendrogenesis: Significance in Alcohol Use Disorders |
title_sort |
platelet endothelial cell adhesion molecule-1 and oligodendrogenesis: significance in alcohol use disorders |
publisher |
MDPI AG |
series |
Brain Sciences |
issn |
2076-3425 |
publishDate |
2017-10-01 |
description |
Alcoholism is a chronic relapsing disorder with few therapeutic strategies that address the core pathophysiology. Brain tissue loss and oxidative damage are key components of alcoholism, such that reversal of these phenomena may help break the addictive cycle in alcohol use disorder (AUD). The current review focuses on platelet endothelial cell adhesion molecule 1 (PECAM-1), a key modulator of the cerebral endothelial integrity and neuroinflammation, and a targetable transmembrane protein whose interaction within AUD has not been well explored. The current review will elaborate on the function of PECAM-1 in physiology and pathology and infer its contribution in AUD neuropathology. Recent research reveals that oligodendrocytes, whose primary function is myelination of neurons in the brain, are a key component in new learning and adaptation to environmental challenges. The current review briefly introduces the role of oligodendrocytes in healthy physiology and neuropathology. Importantly, we will highlight the recent evidence of dysregulation of oligodendrocytes in the context of AUD and then discuss their potential interaction with PECAM-1 on the cerebral endothelium. |
topic |
alcohol blood–brain barrier endothelium PECAM-1 oligodendroglia myelin |
url |
https://www.mdpi.com/2076-3425/7/10/131 |
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