Summary: | Most of the debilitating conditions following aneurysmal subarachnoid hemorrhage
result from symptomatic cerebral vasospasm and delayed cerebral ischemia.
Several scales are being used, but they still lack objectivity and fail to
quantify complications considered essential for prognostication routine
use of biomarkers to predict complications and outcomes after aneurysmal rupture
is still experimental. Degradomics were studied extensively in traumatic brain
injury, but there is no discussion of these biomarkers related to aneurysmal
subarachnoid hemorrhage. Degradomics involve the activation of proteases that
target specific substrates and generate specific protein fragments called
degradomes. While the proteolytic activities constitute the pillar of
development, growth, and regeneration of tissues, dysregulated proteolysis
resulting from pathological conditions like aneurysmal subarachnoid hemorrhage
ends up in apoptotic processes and necrosis. To our knowledge, this is the first
overview that lists a panel of degradomics with cut-off values in serum
and cerebrospinal fluid, where specificity and sensitivity are only found in
Kallikrein 6, Ubiquitin C Terminal Hydrolase 1 and Alpha-II-Spectrin.
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