Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells

Secreted proteins present a rich resource of potential cancer biomarkers. Here, the authors use mass spectrometry to analyze secretome remodeling in pulmonary neuroendocrine lung cancer cell lines and validate potential biomarkers and therapeutic targets in vitro and in mouse models.

Bibliographic Details
Main Authors:	Xu-Dong Wang, Rongkuan Hu, Qing Ding, Trisha K. Savage, Kenneth E. Huffman, Noelle Williams, Melanie H. Cobb, John D. Minna, Jane E. Johnson, Yonghao Yu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-11153-5

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spelling	doaj-ab493e2c25ce4d6f9e28ead2e5b285422021-05-11T12:35:03ZengNature Publishing GroupNature Communications2041-17232019-07-0110111410.1038/s41467-019-11153-5Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cellsXu-Dong Wang0Rongkuan Hu1Qing Ding2Trisha K. Savage3Kenneth E. Huffman4Noelle Williams5Melanie H. Cobb6John D. Minna7Jane E. Johnson8Yonghao Yu9Department of Biochemistry, University of Texas Southwestern Medical CenterDepartment of Biochemistry, University of Texas Southwestern Medical CenterDepartment of Biochemistry, University of Texas Southwestern Medical CenterDepartment of Neuroscience, University of Texas Southwestern Medical CenterSimmons Comprehensive Cancer Center, University of Texas Southwestern Medical CenterDepartment of Biochemistry, University of Texas Southwestern Medical CenterSimmons Comprehensive Cancer Center, University of Texas Southwestern Medical CenterSimmons Comprehensive Cancer Center, University of Texas Southwestern Medical CenterDepartment of Neuroscience, University of Texas Southwestern Medical CenterDepartment of Biochemistry, University of Texas Southwestern Medical CenterSecreted proteins present a rich resource of potential cancer biomarkers. Here, the authors use mass spectrometry to analyze secretome remodeling in pulmonary neuroendocrine lung cancer cell lines and validate potential biomarkers and therapeutic targets in vitro and in mouse models.https://doi.org/10.1038/s41467-019-11153-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xu-Dong Wang Rongkuan Hu Qing Ding Trisha K. Savage Kenneth E. Huffman Noelle Williams Melanie H. Cobb John D. Minna Jane E. Johnson Yonghao Yu
spellingShingle	Xu-Dong Wang Rongkuan Hu Qing Ding Trisha K. Savage Kenneth E. Huffman Noelle Williams Melanie H. Cobb John D. Minna Jane E. Johnson Yonghao Yu Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells Nature Communications
author_facet	Xu-Dong Wang Rongkuan Hu Qing Ding Trisha K. Savage Kenneth E. Huffman Noelle Williams Melanie H. Cobb John D. Minna Jane E. Johnson Yonghao Yu
author_sort	Xu-Dong Wang
title	Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells
title_short	Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells
title_full	Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells
title_fullStr	Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells
title_full_unstemmed	Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells
title_sort	subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-07-01
description	Secreted proteins present a rich resource of potential cancer biomarkers. Here, the authors use mass spectrometry to analyze secretome remodeling in pulmonary neuroendocrine lung cancer cell lines and validate potential biomarkers and therapeutic targets in vitro and in mouse models.
url	https://doi.org/10.1038/s41467-019-11153-5
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Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells

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