Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells
Secreted proteins present a rich resource of potential cancer biomarkers. Here, the authors use mass spectrometry to analyze secretome remodeling in pulmonary neuroendocrine lung cancer cell lines and validate potential biomarkers and therapeutic targets in vitro and in mouse models.
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Nature Publishing Group
2019-07-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-11153-5 |
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doaj-ab493e2c25ce4d6f9e28ead2e5b285422021-05-11T12:35:03ZengNature Publishing GroupNature Communications2041-17232019-07-0110111410.1038/s41467-019-11153-5Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cellsXu-Dong Wang0Rongkuan Hu1Qing Ding2Trisha K. Savage3Kenneth E. Huffman4Noelle Williams5Melanie H. Cobb6John D. Minna7Jane E. Johnson8Yonghao Yu9Department of Biochemistry, University of Texas Southwestern Medical CenterDepartment of Biochemistry, University of Texas Southwestern Medical CenterDepartment of Biochemistry, University of Texas Southwestern Medical CenterDepartment of Neuroscience, University of Texas Southwestern Medical CenterSimmons Comprehensive Cancer Center, University of Texas Southwestern Medical CenterDepartment of Biochemistry, University of Texas Southwestern Medical CenterSimmons Comprehensive Cancer Center, University of Texas Southwestern Medical CenterSimmons Comprehensive Cancer Center, University of Texas Southwestern Medical CenterDepartment of Neuroscience, University of Texas Southwestern Medical CenterDepartment of Biochemistry, University of Texas Southwestern Medical CenterSecreted proteins present a rich resource of potential cancer biomarkers. Here, the authors use mass spectrometry to analyze secretome remodeling in pulmonary neuroendocrine lung cancer cell lines and validate potential biomarkers and therapeutic targets in vitro and in mouse models.https://doi.org/10.1038/s41467-019-11153-5 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xu-Dong Wang Rongkuan Hu Qing Ding Trisha K. Savage Kenneth E. Huffman Noelle Williams Melanie H. Cobb John D. Minna Jane E. Johnson Yonghao Yu |
spellingShingle |
Xu-Dong Wang Rongkuan Hu Qing Ding Trisha K. Savage Kenneth E. Huffman Noelle Williams Melanie H. Cobb John D. Minna Jane E. Johnson Yonghao Yu Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells Nature Communications |
author_facet |
Xu-Dong Wang Rongkuan Hu Qing Ding Trisha K. Savage Kenneth E. Huffman Noelle Williams Melanie H. Cobb John D. Minna Jane E. Johnson Yonghao Yu |
author_sort |
Xu-Dong Wang |
title |
Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells |
title_short |
Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells |
title_full |
Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells |
title_fullStr |
Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells |
title_full_unstemmed |
Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells |
title_sort |
subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2019-07-01 |
description |
Secreted proteins present a rich resource of potential cancer biomarkers. Here, the authors use mass spectrometry to analyze secretome remodeling in pulmonary neuroendocrine lung cancer cell lines and validate potential biomarkers and therapeutic targets in vitro and in mouse models. |
url |
https://doi.org/10.1038/s41467-019-11153-5 |
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