Factors predicting good outcome of intravenous thrombolysis in stroke patients before rt-PA administration
Background: To determine whether it is possible to predict intravenous thrombolytic therapy (IVT) outcome after 3 months in acute ischemic stroke patients who are candidate to receive recombinant tissue plasminogen activator (rt-PA), before rt-PA administration based on their risk factors and some a...
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doaj-ab4d6eb4d4054980a13c0b5a407714192020-11-25T02:20:38ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722019-09-01104424430Factors predicting good outcome of intravenous thrombolysis in stroke patients before rt-PA administrationMasoud Mehrpour0Motahareh Afrakhteh1Seyedeh Fahimeh Shojaei2Ahmad Sohrabi3Rezan Ashayeri4Sara Esmaeili5Maryam Bahadori6 Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, (IUMS), Tehran, Iran Department of Neurology, Firoozgar Hospital Iran, University of Medical Sciences (IUMS) Tehran, Iran Firoozgar Clinical Research and Development Center(FCRDC), Iran University of Medical Sciences(IUMS) , Tehran,Iran Infectious disease research center, Golestan University of Medical Sciences, Gorgan, Iran Department of Neurology, Firoozgar Hospital Iran, University of Medical Sciences (IUMS) Tehran, Iran Department of Neurology, Firoozgar Hospital Iran, University of Medical Sciences (IUMS) Tehran, Iran Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences(IUMS), Tehran, Iran Background: To determine whether it is possible to predict intravenous thrombolytic therapy (IVT) outcome after 3 months in acute ischemic stroke patients who are candidate to receive recombinant tissue plasminogen activator (rt-PA), before rt-PA administration based on their risk factors and some available laboratory results. Methods: We enrolled 118 ischemic stroke patients who were treated with standard dose of Alteplase in our hospital. Baseline characteristics, door-to-needle time (DTN), onset-to-treatment time (OTT), the National Institute Health Stroke Scale (NIHSS), systolic and diastolic blood pressure on admission, history of diabetes, hypertension, dyslipidemia, coronary artery disease (CAD), previous ischemic stroke, atrial fibrillation (AF), laboratory results were retrospectively collected. The modified Rankin Scale (mRS) was recorded after 3 months of admission and patients were divided into good (mRS£ 2) and poor (mRS>2) outcome groups. Chi-square test and t-test were used for categorical and continuous variables, respectively. Predictors for outcome after 3 months were studied by multivariable logistic regression. Results: Good outcome was seen in 60 (51%) patients and poor outcome was seen in 58 (49%) patients. Significant predictors for outcome at 3 months according to multivariable regression analysis were NIHSS score (odds ratio [OR], 0.61; 95% confidence interval [CI], 0.498-0.750; p<0.001), SBP (OR, 0.95; 95% CI, 0.925-0.991; P=0.01), AF (OR, 0.09; 95% CI, 0.013- 0.708; P=0.02), CAD (OR, 17.08; 95% CI, 0.013-0.708; p=0.003). Conclusion: Higher NIHSS score, higher SBP on admission, AF and history of CAD could be the independent predictors of outcome after IVT in acute ischemic stroke patients.http://caspjim.com/article-1-1610-en.htmlischemic strokethrombolytic therapyrt-pa |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Masoud Mehrpour Motahareh Afrakhteh Seyedeh Fahimeh Shojaei Ahmad Sohrabi Rezan Ashayeri Sara Esmaeili Maryam Bahadori |
spellingShingle |
Masoud Mehrpour Motahareh Afrakhteh Seyedeh Fahimeh Shojaei Ahmad Sohrabi Rezan Ashayeri Sara Esmaeili Maryam Bahadori Factors predicting good outcome of intravenous thrombolysis in stroke patients before rt-PA administration Caspian Journal of Internal Medicine ischemic stroke thrombolytic therapy rt-pa |
author_facet |
Masoud Mehrpour Motahareh Afrakhteh Seyedeh Fahimeh Shojaei Ahmad Sohrabi Rezan Ashayeri Sara Esmaeili Maryam Bahadori |
author_sort |
Masoud Mehrpour |
title |
Factors predicting good outcome of intravenous thrombolysis in stroke patients before rt-PA administration |
title_short |
Factors predicting good outcome of intravenous thrombolysis in stroke patients before rt-PA administration |
title_full |
Factors predicting good outcome of intravenous thrombolysis in stroke patients before rt-PA administration |
title_fullStr |
Factors predicting good outcome of intravenous thrombolysis in stroke patients before rt-PA administration |
title_full_unstemmed |
Factors predicting good outcome of intravenous thrombolysis in stroke patients before rt-PA administration |
title_sort |
factors predicting good outcome of intravenous thrombolysis in stroke patients before rt-pa administration |
publisher |
Babol University of Medical Sciences |
series |
Caspian Journal of Internal Medicine |
issn |
2008-6164 2008-6172 |
publishDate |
2019-09-01 |
description |
Background: To determine whether it is possible to predict intravenous thrombolytic therapy (IVT) outcome after 3 months in acute ischemic stroke patients who are candidate to receive recombinant tissue plasminogen activator (rt-PA), before rt-PA administration based on their risk factors and some available laboratory results.
Methods: We enrolled 118 ischemic stroke patients who were treated with standard dose of Alteplase in our hospital. Baseline characteristics, door-to-needle time (DTN), onset-to-treatment time (OTT), the National Institute Health Stroke Scale (NIHSS), systolic and diastolic blood pressure on admission, history of diabetes, hypertension, dyslipidemia, coronary artery disease (CAD), previous ischemic stroke, atrial fibrillation (AF), laboratory results were retrospectively collected. The modified Rankin Scale (mRS) was recorded after 3 months of admission and patients were divided into good (mRS£ 2) and poor (mRS>2) outcome groups. Chi-square test and t-test were used for categorical and continuous variables, respectively. Predictors for outcome after 3 months were studied by multivariable logistic regression.
Results: Good outcome was seen in 60 (51%) patients and poor outcome was seen in 58 (49%) patients. Significant predictors for outcome at 3 months according to multivariable regression analysis were NIHSS score (odds ratio [OR], 0.61; 95% confidence interval [CI], 0.498-0.750; p<0.001), SBP (OR, 0.95; 95% CI, 0.925-0.991; P=0.01), AF (OR, 0.09; 95% CI, 0.013- 0.708; P=0.02), CAD (OR, 17.08; 95% CI, 0.013-0.708; p=0.003).
Conclusion: Higher NIHSS score, higher SBP on admission, AF and history of CAD could be the independent predictors of outcome after IVT in acute ischemic stroke patients. |
topic |
ischemic stroke thrombolytic therapy rt-pa |
url |
http://caspjim.com/article-1-1610-en.html |
work_keys_str_mv |
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