The role of human papillomavirus (HPV) testing in the follow-up of patients after treatment for cervical intraepithelial neoplasia (CIN)
Introduction: The aim of this study was to examine the role of human papillomavirus testing in the follow-up after treatment for CIN, as a prognostic sign for residual/recurrent cervical precancerous lesions. Methods: A hospital-based analysis was performed on 460 patients previously treated for CIN...
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doaj-ab4deac98a1e4cc485ba0786bce82d802020-11-25T02:51:25ZengUniversity of SarajevoJournal of Health Sciences 2232-75761986-80492013-09-013210.17532/jhsci.2013.7562The role of human papillomavirus (HPV) testing in the follow-up of patients after treatment for cervical intraepithelial neoplasia (CIN)Goran Dimitrov0Elena Dzikova1Gligor Dimitrov2Saso Panov3Irena Aleksioska4Gjorgji Babusku5University Clinic for Gynecology and Obstetrics, Ss. Cyril and Methodius University, Vod-njanska Street No.17 , 1000 Skopje,Republic of MacedoniaUniversity Clinic for Gynecology and Obstetrics, Ss. Cyril and Methodius University, Vod-njanska Street No.17 , 1000 Skopje,Republic of MacedoniaGeneral Hospital Remedika, 16-ta Makedonska brigada Street No.18, 1000 Skopje, Republic of MacedoniaInstitute of Biology, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University, Skopje,Republic of MacedoniaUniversity Clinic for Gynecology and Obstetrics, Ss. Cyril and Methodius University, Vod-njanska Street No.17 , 1000 Skopje,Republic of MacedoniaGeneral Hospital Remedika, 16-ta Makedonska brigada Street No.18, 1000 Skopje, Republic of MacedoniaIntroduction: The aim of this study was to examine the role of human papillomavirus testing in the follow-up after treatment for CIN, as a prognostic sign for residual/recurrent cervical precancerous lesions. Methods: A hospital-based analysis was performed on 460 patients previously treated for CIN with cold knife conization, at the University Clinic for Gynecology and Obstetrics and General Hospital Remedika, in Skopje, Republic of Macedonia, in a period of 3 years. The patients were followed-up with HPV testing in addition to cytology, colposcopy and/or biopsy. The first after treatment HPV testing was performed 8 months after cold knife conization, proceeded by follow-up within 24 months after treatment, at 4 months intervals. Results: Among 460 treated patients, at the fi rst HPV and cytologic testing, 8 months after treat-ment, 69 (15%) were HPV+, and 391 (85%) HPV negative. From the 69 HPV+ patients, 41 (59.4%) were with cytologic abnormalities and 28 (40.6%) without abnormalities. 12 months after treatment, the number of HPV+ patients developing cytologic abnormalities raised to 45/70 (64.29%). Within the 24 months after treatment, the number of patients who had recurrent/ residual CIN from the HPV+ patients reached 50/71 (70.42%); which was 10.87% from all 460 treated patients. Conclusion: Persistence or clearance of HPV especially 8 months after treatment even in patients with normal cytology, is an early valid prognostic marker of treatment failure, and is more accurate than cytology at the same follow-up intervals.https://www.jhsci.ba/ojs/index.php/jhsci/article/view/111human papillomavirusuterine cervix carcinomaHPVcervical intraepithelial neoplasia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Goran Dimitrov Elena Dzikova Gligor Dimitrov Saso Panov Irena Aleksioska Gjorgji Babusku |
spellingShingle |
Goran Dimitrov Elena Dzikova Gligor Dimitrov Saso Panov Irena Aleksioska Gjorgji Babusku The role of human papillomavirus (HPV) testing in the follow-up of patients after treatment for cervical intraepithelial neoplasia (CIN) Journal of Health Sciences human papillomavirus uterine cervix carcinoma HPV cervical intraepithelial neoplasia |
author_facet |
Goran Dimitrov Elena Dzikova Gligor Dimitrov Saso Panov Irena Aleksioska Gjorgji Babusku |
author_sort |
Goran Dimitrov |
title |
The role of human papillomavirus (HPV) testing in the follow-up of patients after treatment for cervical intraepithelial neoplasia (CIN) |
title_short |
The role of human papillomavirus (HPV) testing in the follow-up of patients after treatment for cervical intraepithelial neoplasia (CIN) |
title_full |
The role of human papillomavirus (HPV) testing in the follow-up of patients after treatment for cervical intraepithelial neoplasia (CIN) |
title_fullStr |
The role of human papillomavirus (HPV) testing in the follow-up of patients after treatment for cervical intraepithelial neoplasia (CIN) |
title_full_unstemmed |
The role of human papillomavirus (HPV) testing in the follow-up of patients after treatment for cervical intraepithelial neoplasia (CIN) |
title_sort |
role of human papillomavirus (hpv) testing in the follow-up of patients after treatment for cervical intraepithelial neoplasia (cin) |
publisher |
University of Sarajevo |
series |
Journal of Health Sciences |
issn |
2232-7576 1986-8049 |
publishDate |
2013-09-01 |
description |
Introduction: The aim of this study was to examine the role of human papillomavirus testing in the follow-up after treatment for CIN, as a prognostic sign for residual/recurrent cervical precancerous lesions.
Methods: A hospital-based analysis was performed on 460 patients previously treated for CIN with cold knife conization, at the University Clinic for Gynecology and Obstetrics and General Hospital Remedika, in Skopje, Republic of Macedonia, in a period of 3 years. The patients were followed-up with HPV testing in addition to cytology, colposcopy and/or biopsy. The first after treatment HPV testing was performed
8 months after cold knife conization, proceeded by follow-up within 24 months after treatment, at 4 months intervals.
Results: Among 460 treated patients, at the fi rst HPV and cytologic testing, 8 months after treat-ment, 69 (15%) were HPV+, and 391 (85%) HPV negative. From the 69 HPV+ patients, 41 (59.4%) were with
cytologic abnormalities and 28 (40.6%) without abnormalities. 12 months after treatment, the number of HPV+ patients developing cytologic abnormalities raised to 45/70 (64.29%). Within the 24 months after
treatment, the number of patients who had recurrent/ residual CIN from the HPV+ patients reached 50/71 (70.42%); which was 10.87% from all 460 treated patients.
Conclusion: Persistence or clearance of HPV especially 8 months after treatment even in patients with normal cytology, is an early valid prognostic marker of treatment failure, and is more accurate than cytology
at the same follow-up intervals. |
topic |
human papillomavirus uterine cervix carcinoma HPV cervical intraepithelial neoplasia |
url |
https://www.jhsci.ba/ojs/index.php/jhsci/article/view/111 |
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