Metformin Ameliorates Lipopolysaccharide-Induced Depressive-Like Behaviors and Abnormal Glutamatergic Transmission
Metformin, a first-line drug for type 2 diabetes mellitus (T2DM), has been found to reduce depressive symptoms in patients with comorbid depression and other diseases. However, it is largely unclear how metformin ameliorates depressive-like behaviors. Here, we used lipopolysaccharide (LPS) to induce...
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doaj-ab59fb1efedc4a7a8fc7a9d909b040d82020-11-25T03:58:31ZengMDPI AGBiology2079-77372020-10-01935935910.3390/biology9110359Metformin Ameliorates Lipopolysaccharide-Induced Depressive-Like Behaviors and Abnormal Glutamatergic TransmissionJiang Chen0Tian Zhou1A-Min Guo2Wen-Bing Chen3Dong Lin4Zi-Yang Liu5Er-Kang Fei6Laboratory of Synaptic Development and Plasticity, Institute of Life Science, Nanchang University, Nanchang 330031, ChinaSchool of Basic Medical Sciences, Nanchang University, Nanchang 330031, ChinaLaboratory of Synaptic Development and Plasticity, Institute of Life Science, Nanchang University, Nanchang 330031, ChinaLaboratory of Synaptic Development and Plasticity, Institute of Life Science, Nanchang University, Nanchang 330031, ChinaLaboratory of Synaptic Development and Plasticity, Institute of Life Science, Nanchang University, Nanchang 330031, ChinaLaboratory of Synaptic Development and Plasticity, Institute of Life Science, Nanchang University, Nanchang 330031, ChinaLaboratory of Synaptic Development and Plasticity, Institute of Life Science, Nanchang University, Nanchang 330031, ChinaMetformin, a first-line drug for type 2 diabetes mellitus (T2DM), has been found to reduce depressive symptoms in patients with comorbid depression and other diseases. However, it is largely unclear how metformin ameliorates depressive-like behaviors. Here, we used lipopolysaccharide (LPS) to induce depressive-like behaviors in mice and found that LPS-treated mice exhibited increased immobility in the forced swimming test (FST) and tail suspension test (TST), as well as increased glutamatergic transmission. Furthermore, metformin administration in the LPS-treated mice ameliorated depressive-like behaviors and elevated glutamatergic transmission. Our results suggest that metformin has antidepressant effects and can correct abnormal glutamatergic transmission, providing an insight into the underlying mechanism by which metformin acts against depression.https://www.mdpi.com/2079-7737/9/11/359depressionmetforminlipopolysaccharide (LPS)synaptic transmission |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiang Chen Tian Zhou A-Min Guo Wen-Bing Chen Dong Lin Zi-Yang Liu Er-Kang Fei |
spellingShingle |
Jiang Chen Tian Zhou A-Min Guo Wen-Bing Chen Dong Lin Zi-Yang Liu Er-Kang Fei Metformin Ameliorates Lipopolysaccharide-Induced Depressive-Like Behaviors and Abnormal Glutamatergic Transmission Biology depression metformin lipopolysaccharide (LPS) synaptic transmission |
author_facet |
Jiang Chen Tian Zhou A-Min Guo Wen-Bing Chen Dong Lin Zi-Yang Liu Er-Kang Fei |
author_sort |
Jiang Chen |
title |
Metformin Ameliorates Lipopolysaccharide-Induced Depressive-Like Behaviors and Abnormal Glutamatergic Transmission |
title_short |
Metformin Ameliorates Lipopolysaccharide-Induced Depressive-Like Behaviors and Abnormal Glutamatergic Transmission |
title_full |
Metformin Ameliorates Lipopolysaccharide-Induced Depressive-Like Behaviors and Abnormal Glutamatergic Transmission |
title_fullStr |
Metformin Ameliorates Lipopolysaccharide-Induced Depressive-Like Behaviors and Abnormal Glutamatergic Transmission |
title_full_unstemmed |
Metformin Ameliorates Lipopolysaccharide-Induced Depressive-Like Behaviors and Abnormal Glutamatergic Transmission |
title_sort |
metformin ameliorates lipopolysaccharide-induced depressive-like behaviors and abnormal glutamatergic transmission |
publisher |
MDPI AG |
series |
Biology |
issn |
2079-7737 |
publishDate |
2020-10-01 |
description |
Metformin, a first-line drug for type 2 diabetes mellitus (T2DM), has been found to reduce depressive symptoms in patients with comorbid depression and other diseases. However, it is largely unclear how metformin ameliorates depressive-like behaviors. Here, we used lipopolysaccharide (LPS) to induce depressive-like behaviors in mice and found that LPS-treated mice exhibited increased immobility in the forced swimming test (FST) and tail suspension test (TST), as well as increased glutamatergic transmission. Furthermore, metformin administration in the LPS-treated mice ameliorated depressive-like behaviors and elevated glutamatergic transmission. Our results suggest that metformin has antidepressant effects and can correct abnormal glutamatergic transmission, providing an insight into the underlying mechanism by which metformin acts against depression. |
topic |
depression metformin lipopolysaccharide (LPS) synaptic transmission |
url |
https://www.mdpi.com/2079-7737/9/11/359 |
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