Decrease in regulatory T-cell function in chronic hepatitis C patients receiving pegylated-interferon plus ribavirin
Objectives: Regulatory T-cells (Tregs) play an important role in the pathogenesis of chronic hepatitis C (CHC) infection. Pegylated interferon is the standard therapy for CHC patients in Asian countries. This study aimed to evaluate the frequency and function of Tregs in CHC patients receiving combi...
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doaj-ab5c8d1e9dd4452e9ef64f7bd268887b2020-11-24T23:58:52ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112017-05-0158C81710.1016/j.ijid.2017.02.015Decrease in regulatory T-cell function in chronic hepatitis C patients receiving pegylated-interferon plus ribavirinKuo-Chih Tseng0Yun-Che Ho1Chi-Wei Tseng2Ling-Huei Tseng3Yu-Hsi Hsieh4Ting-Tsung Chang5Shu-Fen Wu6Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chia-Yi, TaiwanDepartment of Life Science and Institute of Molecular Biology, National Chung Cheng University, No. 168, University Rd, Min-Hsiung, Chia-Yi, 62102, TaiwanDepartment of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chia-Yi, TaiwanDepartment of Life Science and Institute of Molecular Biology, National Chung Cheng University, No. 168, University Rd, Min-Hsiung, Chia-Yi, 62102, TaiwanDepartment of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chia-Yi, TaiwanDepartment of Internal Medicine, National Cheng Kung University Medical College and Hospital, Tainan, TaiwanDepartment of Life Science and Institute of Molecular Biology, National Chung Cheng University, No. 168, University Rd, Min-Hsiung, Chia-Yi, 62102, TaiwanObjectives: Regulatory T-cells (Tregs) play an important role in the pathogenesis of chronic hepatitis C (CHC) infection. Pegylated interferon is the standard therapy for CHC patients in Asian countries. This study aimed to evaluate the frequency and function of Tregs in CHC patients receiving combination therapy. Methods: CHC patients (n = 30) who had elevated alanine aminotransferase and underwent combination therapy were included. Clinical data and Treg function were checked at baseline, 12 weeks after treatment, at the end of treatment, and at the end of 24 weeks of follow-up. Treg immunosuppressive activity was measured as the inhibition ratio of conventional T-cell proliferation. Results: Treg-mediated immunosuppression was significantly lower during therapy than at baseline (baseline 44.45%; 12 weeks 18.41% (p = 0.042); end of treatment 22.62% (p = 0.036); end of follow-up 17.46% (p = 0.003)). Treg-mediated immunosuppression was higher in patients with a sustained virological response (SVR) than in those without SVR at the end of follow-up (SVR 24.20%, non-SVR 6.87%; p = 0.030). Conclusion: Treg-mediated immunosuppression was lower during and after combination therapy, regardless of the treatment response, and higher in patients with SVR than in those without SVR at the end of follow-up.http://www.sciencedirect.com/science/article/pii/S1201971217300620Hepatitis CFunctionInhibitionInterferonRegulatory T-cells |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kuo-Chih Tseng Yun-Che Ho Chi-Wei Tseng Ling-Huei Tseng Yu-Hsi Hsieh Ting-Tsung Chang Shu-Fen Wu |
spellingShingle |
Kuo-Chih Tseng Yun-Che Ho Chi-Wei Tseng Ling-Huei Tseng Yu-Hsi Hsieh Ting-Tsung Chang Shu-Fen Wu Decrease in regulatory T-cell function in chronic hepatitis C patients receiving pegylated-interferon plus ribavirin International Journal of Infectious Diseases Hepatitis C Function Inhibition Interferon Regulatory T-cells |
author_facet |
Kuo-Chih Tseng Yun-Che Ho Chi-Wei Tseng Ling-Huei Tseng Yu-Hsi Hsieh Ting-Tsung Chang Shu-Fen Wu |
author_sort |
Kuo-Chih Tseng |
title |
Decrease in regulatory T-cell function in chronic hepatitis C patients receiving pegylated-interferon plus ribavirin |
title_short |
Decrease in regulatory T-cell function in chronic hepatitis C patients receiving pegylated-interferon plus ribavirin |
title_full |
Decrease in regulatory T-cell function in chronic hepatitis C patients receiving pegylated-interferon plus ribavirin |
title_fullStr |
Decrease in regulatory T-cell function in chronic hepatitis C patients receiving pegylated-interferon plus ribavirin |
title_full_unstemmed |
Decrease in regulatory T-cell function in chronic hepatitis C patients receiving pegylated-interferon plus ribavirin |
title_sort |
decrease in regulatory t-cell function in chronic hepatitis c patients receiving pegylated-interferon plus ribavirin |
publisher |
Elsevier |
series |
International Journal of Infectious Diseases |
issn |
1201-9712 1878-3511 |
publishDate |
2017-05-01 |
description |
Objectives: Regulatory T-cells (Tregs) play an important role in the pathogenesis of chronic hepatitis C (CHC) infection. Pegylated interferon is the standard therapy for CHC patients in Asian countries. This study aimed to evaluate the frequency and function of Tregs in CHC patients receiving combination therapy.
Methods: CHC patients (n = 30) who had elevated alanine aminotransferase and underwent combination therapy were included. Clinical data and Treg function were checked at baseline, 12 weeks after treatment, at the end of treatment, and at the end of 24 weeks of follow-up. Treg immunosuppressive activity was measured as the inhibition ratio of conventional T-cell proliferation.
Results: Treg-mediated immunosuppression was significantly lower during therapy than at baseline (baseline 44.45%; 12 weeks 18.41% (p = 0.042); end of treatment 22.62% (p = 0.036); end of follow-up 17.46% (p = 0.003)). Treg-mediated immunosuppression was higher in patients with a sustained virological response (SVR) than in those without SVR at the end of follow-up (SVR 24.20%, non-SVR 6.87%; p = 0.030).
Conclusion: Treg-mediated immunosuppression was lower during and after combination therapy, regardless of the treatment response, and higher in patients with SVR than in those without SVR at the end of follow-up. |
topic |
Hepatitis C Function Inhibition Interferon Regulatory T-cells |
url |
http://www.sciencedirect.com/science/article/pii/S1201971217300620 |
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