Selenium-Doped Hydroxyapatite Nanocrystals–Synthesis, Physicochemical Properties and Biological Significance
Hydroxyapatites (HAs), as materials with a similar structure to bone minerals, play a key role in biomaterials engineering. They have been applied as bone substitute materials and as coatings for metallic implants, which facilitates their osseointegration. One of the beneficial characteristics of HA...
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doaj-ab66ef0d1a1840e7a51c21dbc5ba15452020-11-25T00:29:55ZengMDPI AGCrystals2073-43522018-04-018518810.3390/cryst8050188cryst8050188Selenium-Doped Hydroxyapatite Nanocrystals–Synthesis, Physicochemical Properties and Biological SignificanceKamil Pajor0Lukasz Pajchel1Barbara Kolodziejska2Joanna Kolmas3Chair and Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy with Laboratory Medicine Division, Medical University of Warsaw, ul. Banacha 1, 02-097 Warsaw, PolandChair and Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy with Laboratory Medicine Division, Medical University of Warsaw, ul. Banacha 1, 02-097 Warsaw, PolandChair and Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy with Laboratory Medicine Division, Medical University of Warsaw, ul. Banacha 1, 02-097 Warsaw, PolandChair and Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy with Laboratory Medicine Division, Medical University of Warsaw, ul. Banacha 1, 02-097 Warsaw, PolandHydroxyapatites (HAs), as materials with a similar structure to bone minerals, play a key role in biomaterials engineering. They have been applied as bone substitute materials and as coatings for metallic implants, which facilitates their osseointegration. One of the beneficial characteristics of HA, when used to create biocompatible materials with improved physicochemical or biological properties, is its capacity for ionic substitution. The aim of the study was to present the current state of knowledge about HAs containing selenate ions IV or VI. The enrichment of HAs with selenium aims to create a material with advantageous effects on bone tissue metabolism, as well as having anticancer and antibacterial activity. The work is devoted to both methods of obtaining Se-HA and an evaluation of its chemical structure and physicochemical properties. In addition, the biological activity of such materials in vitro and in vivo is discussed.http://www.mdpi.com/2073-4352/8/5/188hydroxyapatiteionic substitutionseleniumseleniteselenitephysicochemical propertiesbiomaterialsbioceramics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kamil Pajor Lukasz Pajchel Barbara Kolodziejska Joanna Kolmas |
spellingShingle |
Kamil Pajor Lukasz Pajchel Barbara Kolodziejska Joanna Kolmas Selenium-Doped Hydroxyapatite Nanocrystals–Synthesis, Physicochemical Properties and Biological Significance Crystals hydroxyapatite ionic substitution selenium selenite selenite physicochemical properties biomaterials bioceramics |
author_facet |
Kamil Pajor Lukasz Pajchel Barbara Kolodziejska Joanna Kolmas |
author_sort |
Kamil Pajor |
title |
Selenium-Doped Hydroxyapatite Nanocrystals–Synthesis, Physicochemical Properties and Biological Significance |
title_short |
Selenium-Doped Hydroxyapatite Nanocrystals–Synthesis, Physicochemical Properties and Biological Significance |
title_full |
Selenium-Doped Hydroxyapatite Nanocrystals–Synthesis, Physicochemical Properties and Biological Significance |
title_fullStr |
Selenium-Doped Hydroxyapatite Nanocrystals–Synthesis, Physicochemical Properties and Biological Significance |
title_full_unstemmed |
Selenium-Doped Hydroxyapatite Nanocrystals–Synthesis, Physicochemical Properties and Biological Significance |
title_sort |
selenium-doped hydroxyapatite nanocrystals–synthesis, physicochemical properties and biological significance |
publisher |
MDPI AG |
series |
Crystals |
issn |
2073-4352 |
publishDate |
2018-04-01 |
description |
Hydroxyapatites (HAs), as materials with a similar structure to bone minerals, play a key role in biomaterials engineering. They have been applied as bone substitute materials and as coatings for metallic implants, which facilitates their osseointegration. One of the beneficial characteristics of HA, when used to create biocompatible materials with improved physicochemical or biological properties, is its capacity for ionic substitution. The aim of the study was to present the current state of knowledge about HAs containing selenate ions IV or VI. The enrichment of HAs with selenium aims to create a material with advantageous effects on bone tissue metabolism, as well as having anticancer and antibacterial activity. The work is devoted to both methods of obtaining Se-HA and an evaluation of its chemical structure and physicochemical properties. In addition, the biological activity of such materials in vitro and in vivo is discussed. |
topic |
hydroxyapatite ionic substitution selenium selenite selenite physicochemical properties biomaterials bioceramics |
url |
http://www.mdpi.com/2073-4352/8/5/188 |
work_keys_str_mv |
AT kamilpajor seleniumdopedhydroxyapatitenanocrystalssynthesisphysicochemicalpropertiesandbiologicalsignificance AT lukaszpajchel seleniumdopedhydroxyapatitenanocrystalssynthesisphysicochemicalpropertiesandbiologicalsignificance AT barbarakolodziejska seleniumdopedhydroxyapatitenanocrystalssynthesisphysicochemicalpropertiesandbiologicalsignificance AT joannakolmas seleniumdopedhydroxyapatitenanocrystalssynthesisphysicochemicalpropertiesandbiologicalsignificance |
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1725329085516742656 |