Genomic Analysis of Highly Virulent Georgia 2007/1 Isolate of African Swine Fever Virus
African swine fever is widespread in Africa but has occasionally been introduced into other continents. In June 2007, African swine fever was isolated in the Caucasus Region of the Republic of Georgia and subsequently in neighboring countries (Armenia, Azerbaijan, and 9 states of the Russian Federat...
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doaj-ab6c61e2bf894e39b9238568041ed70a2020-11-25T01:02:58ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592011-04-0117459960510.3201/eid1704.101283Genomic Analysis of Highly Virulent Georgia 2007/1 Isolate of African Swine Fever VirusDavid A.G. ChapmanAlistair C. DarbyMelissa Da SilvaChris UptonAlan D. RadfordLinda K. DixonAfrican swine fever is widespread in Africa but has occasionally been introduced into other continents. In June 2007, African swine fever was isolated in the Caucasus Region of the Republic of Georgia and subsequently in neighboring countries (Armenia, Azerbaijan, and 9 states of the Russian Federation). Previous data for sequencing of 3 genes indicated that the Georgia 2007/1 isolate is closely related to isolates of genotype II, which has been identified in Mozambique, Madagascar, and Zambia. We report the complete genomic coding sequence of the Georgia 2007/1 isolate and comparison with other isolates. A genome sequence of 189,344 bp encoding 166 open reading frames (ORFs) was obtained. Phylogeny based on concatenated sequences of 125 conserved ORFs showed that this isolate clustered most closely with the Mkuzi 1979 isolate. Some ORFs clustered differently, suggesting that recombination may have occurred. Results provide a baseline for monitoring genomic changes in this virus.https://wwwnc.cdc.gov/eid/article/17/4/10-1283_articleAfrican swine fevervirusesgenomic analysisvirulenceoutbreakRepublic of Georgia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
David A.G. Chapman Alistair C. Darby Melissa Da Silva Chris Upton Alan D. Radford Linda K. Dixon |
spellingShingle |
David A.G. Chapman Alistair C. Darby Melissa Da Silva Chris Upton Alan D. Radford Linda K. Dixon Genomic Analysis of Highly Virulent Georgia 2007/1 Isolate of African Swine Fever Virus Emerging Infectious Diseases African swine fever viruses genomic analysis virulence outbreak Republic of Georgia |
author_facet |
David A.G. Chapman Alistair C. Darby Melissa Da Silva Chris Upton Alan D. Radford Linda K. Dixon |
author_sort |
David A.G. Chapman |
title |
Genomic Analysis of Highly Virulent Georgia 2007/1 Isolate of African Swine Fever Virus |
title_short |
Genomic Analysis of Highly Virulent Georgia 2007/1 Isolate of African Swine Fever Virus |
title_full |
Genomic Analysis of Highly Virulent Georgia 2007/1 Isolate of African Swine Fever Virus |
title_fullStr |
Genomic Analysis of Highly Virulent Georgia 2007/1 Isolate of African Swine Fever Virus |
title_full_unstemmed |
Genomic Analysis of Highly Virulent Georgia 2007/1 Isolate of African Swine Fever Virus |
title_sort |
genomic analysis of highly virulent georgia 2007/1 isolate of african swine fever virus |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2011-04-01 |
description |
African swine fever is widespread in Africa but has occasionally been introduced into other continents. In June 2007, African swine fever was isolated in the Caucasus Region of the Republic of Georgia and subsequently in neighboring countries (Armenia, Azerbaijan, and 9 states of the Russian Federation). Previous data for sequencing of 3 genes indicated that the Georgia 2007/1 isolate is closely related to isolates of genotype II, which has been identified in Mozambique, Madagascar, and Zambia. We report the complete genomic coding sequence of the Georgia 2007/1 isolate and comparison with other isolates. A genome sequence of 189,344 bp encoding 166 open reading frames (ORFs) was obtained. Phylogeny based on concatenated sequences of 125 conserved ORFs showed that this isolate clustered most closely with the Mkuzi 1979 isolate. Some ORFs clustered differently, suggesting that recombination may have occurred. Results provide a baseline for monitoring genomic changes in this virus. |
topic |
African swine fever viruses genomic analysis virulence outbreak Republic of Georgia |
url |
https://wwwnc.cdc.gov/eid/article/17/4/10-1283_article |
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