Celiac Disease and the Microbiome
Growing evidence supports the hypothesis that changes in both the composition and function of the intestinal microbiome are associated with a number of chronic inflammatory diseases including celiac disease (CD). One of the major advances in the field of microbiome studies over the last few decades...
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2019-10-01
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doaj-ab717cc10aba461e9ff98e190c65bf752020-11-25T01:32:42ZengMDPI AGNutrients2072-66432019-10-011110240310.3390/nu11102403nu11102403Celiac Disease and the MicrobiomeFrancesco Valitutti0Salvatore Cucchiara1Alessio Fasano2Pediatric Gastroenterology and Liver Unit, Department of “Maternal-and-Child Health” and Urology, Sapienza University of Rome, 00185 Rome, ItalyPediatric Gastroenterology and Liver Unit, Department of “Maternal-and-Child Health” and Urology, Sapienza University of Rome, 00185 Rome, ItalyEuropean Biomedical Research Institute of Salerno, 84125 Salerno, ItalyGrowing evidence supports the hypothesis that changes in both the composition and function of the intestinal microbiome are associated with a number of chronic inflammatory diseases including celiac disease (CD). One of the major advances in the field of microbiome studies over the last few decades has been the development of culture-independent approaches to identify and quantify the components of the human microbiota. The study of nucleic acids DNA and RNA found in feces or other biological samples bypasses the need for tissue cultures and also allows the characterization of non-cultivable microbes. Current evidence on the composition of the intestinal microbiome and its role as a causative trigger for CD is highly heterogeneous and sometimes contradictory. This review is aimed at summarizing both pre-clinical (basic science data) and clinical (cross-sectional and prospective studies) evidence addressing the relationship between the intestinal microbiome and CD.https://www.mdpi.com/2072-6643/11/10/2403celiac diseasemicrobiomemicrobiotaenvironmental factorsat-risk infants |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Francesco Valitutti Salvatore Cucchiara Alessio Fasano |
spellingShingle |
Francesco Valitutti Salvatore Cucchiara Alessio Fasano Celiac Disease and the Microbiome Nutrients celiac disease microbiome microbiota environmental factors at-risk infants |
author_facet |
Francesco Valitutti Salvatore Cucchiara Alessio Fasano |
author_sort |
Francesco Valitutti |
title |
Celiac Disease and the Microbiome |
title_short |
Celiac Disease and the Microbiome |
title_full |
Celiac Disease and the Microbiome |
title_fullStr |
Celiac Disease and the Microbiome |
title_full_unstemmed |
Celiac Disease and the Microbiome |
title_sort |
celiac disease and the microbiome |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2019-10-01 |
description |
Growing evidence supports the hypothesis that changes in both the composition and function of the intestinal microbiome are associated with a number of chronic inflammatory diseases including celiac disease (CD). One of the major advances in the field of microbiome studies over the last few decades has been the development of culture-independent approaches to identify and quantify the components of the human microbiota. The study of nucleic acids DNA and RNA found in feces or other biological samples bypasses the need for tissue cultures and also allows the characterization of non-cultivable microbes. Current evidence on the composition of the intestinal microbiome and its role as a causative trigger for CD is highly heterogeneous and sometimes contradictory. This review is aimed at summarizing both pre-clinical (basic science data) and clinical (cross-sectional and prospective studies) evidence addressing the relationship between the intestinal microbiome and CD. |
topic |
celiac disease microbiome microbiota environmental factors at-risk infants |
url |
https://www.mdpi.com/2072-6643/11/10/2403 |
work_keys_str_mv |
AT francescovalitutti celiacdiseaseandthemicrobiome AT salvatorecucchiara celiacdiseaseandthemicrobiome AT alessiofasano celiacdiseaseandthemicrobiome |
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1725080317142761472 |