Delayed Bladder Perforation Related to Immediate Single Dose Intravesical Doxorubicin Instillation After TURBT: A Case Report and Literature Review

• Main Authors: Adel Alrabadi, Mohannad Abuhamad, Hammam Mansi, Sohaib Alhamss, Nadwa Bustami, Saddam Al Demour, Mousa A Al-Abbadi
• Format: Article
• Language: English
• Published: SAGE Publishing 2021-01-01
• Series: Clinical Medicine Insights: Case Reports
• Online Access: https://doi.org/10.1177/1179547620986158

Introduction: Intravesical chemotherapy instillation immediately after tumor resection is a well-known practice in the management of non-muscle invasive bladder cancer. Despite being largely well tolerated in most cases, it is not devoid of severe and life-threatening complications. Case Presentation: We present an unusual case of bladder perforation that happened 2 weeks after bladder tumor resection. The patient had received single dose intra-vesical instillation of doxorubicin after TUR-BT. Conservative managements failed to achieve bladder healing; as a result, open surgical repair was performed. To the best of our knowledge, this is the first reported case of bladder perforation after intra-vesical doxorubicin instillation. Conclusion: The occurrence of such a rare serious complication in a mostly safe intervention must be taken into consideration. A high index of suspicion, timely management, and proceeding to more invasive surgical treatments when necessary are cornerstones in the management and preserving the bladder.