Protective effects of Desmopressin acetate on retention of spatial memory deficits induced by post-traumatic stress disorder in Rats
Background and Objective: Post-traumatic stress disorder (PTSD) impairs spatial learning and memory. Desmopressin acetate ameliorates the cognitive deficits induced by electroconvulsive shock. This study was designed to evaluate the protective effects of Desmopressin acetate on retention of spatial...
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Golestan University of Medical Sciences
2012-08-01
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doaj-ab81388084694d0c954b325e0a3dd5b32020-11-24T23:04:24ZfasGolestan University of Medical Sciences مجله دانشگاه علوم پزشکی گرگان1562-47652008-40802012-08-011431925Protective effects of Desmopressin acetate on retention of spatial memory deficits induced by post-traumatic stress disorder in RatsMehrabadi S0Makvand Hosseini Sh1Miladi Gorji H2Nikfarjam Haft Asia M3 MSc in Psychology, Faculty of Psychology and Educational Sciences, University of Semnan, Semnan, Iran Associate Professor, Department of Psychology, Faculty of Psychology and Educational Sciences, University of Semnan, Semnan, Iran Assistant Professor, Research Center of Physiology, Faculty of Medicine, Department of Physiology, Semnan University of Medical Sciences, Semnan, Iran MSc in Psychology, Faculty of Psychology and Educational Sciences, University of Semnan, Semnan, Iran Background and Objective: Post-traumatic stress disorder (PTSD) impairs spatial learning and memory. Desmopressin acetate ameliorates the cognitive deficits induced by electroconvulsive shock. This study was designed to evaluate the protective effects of Desmopressin acetate on retention of spatial memory deficits induced by post-traumatic stress disorder in rats. Materials and Methods: In this experimental study twenty one male Wistar rats were used. Animals were trained for 5 consecutive days in Morris water maze and then were randomly assigned in three groups (Vehicle + Sham, Saline + PTSD and Desmopressin acetate + PTSD) and tested in a probe 60 sec in 24h after the last acquisition trial. The groups of PTSD+Desmopressin acetate rats and vehicle+sham, saline+PTSD were injected Desmopressin acetate (10 micro gr/kg body weight) and saline (IP), respectively. Injections performed ten minute prior to PTSD and spatial memory was tested ten minutes later. Data were analyzed using SPSS-16, One-Way ANOVA and Tukey tests. Results: The platform location latency of the Desmopressin acetate+PTSD group was significantly shorter (4.24 sec) than the control group (P<0.05) and also, had significantly smaller average proximity values (33.87 cm) compared to the saline+PTSD group (P<0.05). Desmopressin acetate + PTSD spent significantly more time (21.65%) in the target zone (P<0.05). Conclusion: This study indicated that Desmopressin acetate blocks the ability of PTSD to impair spatial memory retention.http://goums.ac.ir/journal/browse.php?a_code=A-10-1-599&slc_lang=en&sid=1Post traumatic stress disorderMorris water mazeLearningSpatial memory |
collection |
DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
Mehrabadi S Makvand Hosseini Sh Miladi Gorji H Nikfarjam Haft Asia M |
spellingShingle |
Mehrabadi S Makvand Hosseini Sh Miladi Gorji H Nikfarjam Haft Asia M Protective effects of Desmopressin acetate on retention of spatial memory deficits induced by post-traumatic stress disorder in Rats مجله دانشگاه علوم پزشکی گرگان Post traumatic stress disorder Morris water maze Learning Spatial memory |
author_facet |
Mehrabadi S Makvand Hosseini Sh Miladi Gorji H Nikfarjam Haft Asia M |
author_sort |
Mehrabadi S |
title |
Protective effects of Desmopressin acetate on retention of spatial memory deficits induced by post-traumatic stress disorder in Rats |
title_short |
Protective effects of Desmopressin acetate on retention of spatial memory deficits induced by post-traumatic stress disorder in Rats |
title_full |
Protective effects of Desmopressin acetate on retention of spatial memory deficits induced by post-traumatic stress disorder in Rats |
title_fullStr |
Protective effects of Desmopressin acetate on retention of spatial memory deficits induced by post-traumatic stress disorder in Rats |
title_full_unstemmed |
Protective effects of Desmopressin acetate on retention of spatial memory deficits induced by post-traumatic stress disorder in Rats |
title_sort |
protective effects of desmopressin acetate on retention of spatial memory deficits induced by post-traumatic stress disorder in rats |
publisher |
Golestan University of Medical Sciences |
series |
مجله دانشگاه علوم پزشکی گرگان |
issn |
1562-4765 2008-4080 |
publishDate |
2012-08-01 |
description |
Background and Objective: Post-traumatic stress disorder (PTSD) impairs spatial learning and memory. Desmopressin acetate ameliorates the cognitive deficits induced by electroconvulsive shock. This study was designed to evaluate the protective effects of Desmopressin acetate on retention of spatial memory deficits induced by post-traumatic stress disorder in rats. Materials and Methods: In this experimental study twenty one male Wistar rats were used. Animals were trained for 5 consecutive days in Morris water maze and then were randomly assigned in three groups (Vehicle + Sham, Saline + PTSD and Desmopressin acetate + PTSD) and tested in a probe 60 sec in 24h after the last acquisition trial. The groups of PTSD+Desmopressin acetate rats and vehicle+sham, saline+PTSD were injected Desmopressin acetate (10 micro gr/kg body weight) and saline (IP), respectively. Injections performed ten minute prior to PTSD and spatial memory was tested ten minutes later. Data were analyzed using SPSS-16, One-Way ANOVA and Tukey tests. Results: The platform location latency of the Desmopressin acetate+PTSD group was significantly shorter (4.24 sec) than the control group (P<0.05) and also, had significantly smaller average proximity values (33.87 cm) compared to the saline+PTSD group (P<0.05). Desmopressin acetate + PTSD spent significantly more time (21.65%) in the target zone (P<0.05). Conclusion: This study indicated that Desmopressin acetate blocks the ability of PTSD to impair spatial memory retention. |
topic |
Post traumatic stress disorder Morris water maze Learning Spatial memory |
url |
http://goums.ac.ir/journal/browse.php?a_code=A-10-1-599&slc_lang=en&sid=1 |
work_keys_str_mv |
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