An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role
Binding of T cell receptors (TCR) to peptide-loaded major histocompatibility complexes (p/MHC) leads to T-cell activation. Here the authors give structural insights into T-cell signalling and show that p/MHC binding induces conformational changes at the membrane-proximal site of the TCR.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2017-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15260 |
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doaj-ab8774b12af24665974fefb843895dad2021-05-11T07:53:44ZengNature Publishing GroupNature Communications2041-17232017-05-018111410.1038/ncomms15260An allosteric site in the T-cell receptor Cβ domain plays a critical signalling roleKannan Natarajan0Andrew C. McShan1Jiansheng Jiang2Vlad K Kumirov3Rui Wang4Huaying Zhao5Peter Schuck6Mulualem E. Tilahun7Lisa F. Boyd8Jinfa Ying9Ad Bax10David H. Margulies11Nikolaos G. Sgourakis12Molecular Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of HealthDepartment of Chemistry and Biochemistry, University of California Santa CruzMolecular Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of HealthDepartment of Chemistry and Biochemistry, University of California Santa CruzMolecular Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of HealthLaboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthMolecular Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of HealthMolecular Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of HealthLaboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of HealthLaboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of HealthMolecular Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of HealthDepartment of Chemistry and Biochemistry, University of California Santa CruzBinding of T cell receptors (TCR) to peptide-loaded major histocompatibility complexes (p/MHC) leads to T-cell activation. Here the authors give structural insights into T-cell signalling and show that p/MHC binding induces conformational changes at the membrane-proximal site of the TCR.https://doi.org/10.1038/ncomms15260 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kannan Natarajan Andrew C. McShan Jiansheng Jiang Vlad K Kumirov Rui Wang Huaying Zhao Peter Schuck Mulualem E. Tilahun Lisa F. Boyd Jinfa Ying Ad Bax David H. Margulies Nikolaos G. Sgourakis |
| spellingShingle |
Kannan Natarajan Andrew C. McShan Jiansheng Jiang Vlad K Kumirov Rui Wang Huaying Zhao Peter Schuck Mulualem E. Tilahun Lisa F. Boyd Jinfa Ying Ad Bax David H. Margulies Nikolaos G. Sgourakis An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role Nature Communications |
| author_facet |
Kannan Natarajan Andrew C. McShan Jiansheng Jiang Vlad K Kumirov Rui Wang Huaying Zhao Peter Schuck Mulualem E. Tilahun Lisa F. Boyd Jinfa Ying Ad Bax David H. Margulies Nikolaos G. Sgourakis |
| author_sort |
Kannan Natarajan |
| title |
An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role |
| title_short |
An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role |
| title_full |
An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role |
| title_fullStr |
An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role |
| title_full_unstemmed |
An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role |
| title_sort |
allosteric site in the t-cell receptor cβ domain plays a critical signalling role |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-05-01 |
| description |
Binding of T cell receptors (TCR) to peptide-loaded major histocompatibility complexes (p/MHC) leads to T-cell activation. Here the authors give structural insights into T-cell signalling and show that p/MHC binding induces conformational changes at the membrane-proximal site of the TCR. |
| url |
https://doi.org/10.1038/ncomms15260 |
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