Lost in Transcription: Molecular Mechanisms that Control HIV Latency
Highly active antiretroviral therapy (HAART) has limited the replication and spread of the human immunodeficiency virus (HIV). However, despite treatment, HIV infection persists in latently infected reservoirs, and once therapy is interrupted, viral replication rebounds quickly. Extensive efforts ar...
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Online Access: | http://www.mdpi.com/1999-4915/5/3/902 |
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doaj-ab8b43c076b847e1a88a0c314901a6aa2020-11-24T23:58:49ZengMDPI AGViruses1999-49152013-03-015390292710.3390/v5030902Lost in Transcription: Molecular Mechanisms that Control HIV LatencyMatija PeterlinRan TaubeHighly active antiretroviral therapy (HAART) has limited the replication and spread of the human immunodeficiency virus (HIV). However, despite treatment, HIV infection persists in latently infected reservoirs, and once therapy is interrupted, viral replication rebounds quickly. Extensive efforts are being directed at eliminating these cell reservoirs. This feat can be achieved by reactivating latent HIV while administering drugs that prevent new rounds of infection and allow the immune system to clear the virus. However, current approaches to HIV eradication have not been effective. Moreover, as HIV latency is multifactorial, the significance of each of its molecular mechanisms is still under debate. Among these, transcriptional repression as a result of reduced levels and activity of the positive transcription elongation factor b (P-TEFb: CDK9/cyclin T) plays a significant role. Therefore, increasing levels of P-TEFb expression and activity is an excellent strategy to stimulate viral gene expression. This review summarizes the multiple steps that cause HIV to enter into latency. It positions the interplay between transcriptionally active and inactive host transcriptional activators and their viral partner Tat as valid targets for the development of new strategies to reactivate latent viral gene expression and eradicate HIV.http://www.mdpi.com/1999-4915/5/3/902HIV latencytranscriptional interferenceepigeneticTatpositive transcription elongation factor b (P-TEFb). |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Matija Peterlin Ran Taube |
spellingShingle |
Matija Peterlin Ran Taube Lost in Transcription: Molecular Mechanisms that Control HIV Latency Viruses HIV latency transcriptional interference epigenetic Tat positive transcription elongation factor b (P-TEFb). |
author_facet |
Matija Peterlin Ran Taube |
author_sort |
Matija Peterlin |
title |
Lost in Transcription: Molecular Mechanisms that Control HIV Latency |
title_short |
Lost in Transcription: Molecular Mechanisms that Control HIV Latency |
title_full |
Lost in Transcription: Molecular Mechanisms that Control HIV Latency |
title_fullStr |
Lost in Transcription: Molecular Mechanisms that Control HIV Latency |
title_full_unstemmed |
Lost in Transcription: Molecular Mechanisms that Control HIV Latency |
title_sort |
lost in transcription: molecular mechanisms that control hiv latency |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2013-03-01 |
description |
Highly active antiretroviral therapy (HAART) has limited the replication and spread of the human immunodeficiency virus (HIV). However, despite treatment, HIV infection persists in latently infected reservoirs, and once therapy is interrupted, viral replication rebounds quickly. Extensive efforts are being directed at eliminating these cell reservoirs. This feat can be achieved by reactivating latent HIV while administering drugs that prevent new rounds of infection and allow the immune system to clear the virus. However, current approaches to HIV eradication have not been effective. Moreover, as HIV latency is multifactorial, the significance of each of its molecular mechanisms is still under debate. Among these, transcriptional repression as a result of reduced levels and activity of the positive transcription elongation factor b (P-TEFb: CDK9/cyclin T) plays a significant role. Therefore, increasing levels of P-TEFb expression and activity is an excellent strategy to stimulate viral gene expression. This review summarizes the multiple steps that cause HIV to enter into latency. It positions the interplay between transcriptionally active and inactive host transcriptional activators and their viral partner Tat as valid targets for the development of new strategies to reactivate latent viral gene expression and eradicate HIV. |
topic |
HIV latency transcriptional interference epigenetic Tat positive transcription elongation factor b (P-TEFb). |
url |
http://www.mdpi.com/1999-4915/5/3/902 |
work_keys_str_mv |
AT matijapeterlin lostintranscriptionmolecularmechanismsthatcontrolhivlatency AT rantaube lostintranscriptionmolecularmechanismsthatcontrolhivlatency |
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