Natural and herbal compounds targeting breast cancer, a review based on cancer stem cells
Cancer stem cells (CSCs) are known as the major reason for therapy resistance. Recently, natural herbal compounds are suggested to have a significant role in inhibiting the breast cancer stem cells (BCSCs). The aim of this study was to explore the effective natural herbal compounds against BCSCs.Thi...
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doaj-ab8d243a29d94d63bbcb7e5407af708f2020-11-25T02:29:49ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences 2008-38662008-38742020-08-0123897098310.22038/ijbms.2020.43745.1027015702Natural and herbal compounds targeting breast cancer, a review based on cancer stem cellsAzam Bozorgi0Saber Khazaei1Abbasali Khademi2Mozafar Khazaei3Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, IranDental Research Center, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, IranDental Research Center, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, IranFertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, IranCancer stem cells (CSCs) are known as the major reason for therapy resistance. Recently, natural herbal compounds are suggested to have a significant role in inhibiting the breast cancer stem cells (BCSCs). The aim of this study was to explore the effective natural herbal compounds against BCSCs.This review article was designed based on the BCSCs, mechanisms of therapy resistance and natural herbal compounds effective to inhibit their activity. Therefore, Science direct, PubMed and Scopus databases were explored and related original articles were investigated from 2010 to 2019. BCSCs use different mechanisms including special membrane transporters, anti-apoptotic, pro-survival, and self-renewal- related signaling pathways. Natural herbal compounds could disturb these mechanisms, therefore may inhibit or eradicate the BCSCs. Studies show that a broad range of plants, either as a food or medicine, contain anti-cancer agents that phenolic components and their different derivatives share a large quantity. Natural herbal compounds play a pivotal role in the eradication of BCSCs, through the inhibition of biological activities and induction of apoptosis. Although it is necessary to conduct more clinical investigation.http://ijbms.mums.ac.ir/article_15702_64a6a6eac1e2316923743951d2df3433.pdfbreast neoplasmneoplasmphenolic compoundsstem cellstherapy resistance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Azam Bozorgi Saber Khazaei Abbasali Khademi Mozafar Khazaei |
spellingShingle |
Azam Bozorgi Saber Khazaei Abbasali Khademi Mozafar Khazaei Natural and herbal compounds targeting breast cancer, a review based on cancer stem cells Iranian Journal of Basic Medical Sciences breast neoplasm neoplasm phenolic compounds stem cells therapy resistance |
author_facet |
Azam Bozorgi Saber Khazaei Abbasali Khademi Mozafar Khazaei |
author_sort |
Azam Bozorgi |
title |
Natural and herbal compounds targeting breast cancer, a review based on cancer stem cells |
title_short |
Natural and herbal compounds targeting breast cancer, a review based on cancer stem cells |
title_full |
Natural and herbal compounds targeting breast cancer, a review based on cancer stem cells |
title_fullStr |
Natural and herbal compounds targeting breast cancer, a review based on cancer stem cells |
title_full_unstemmed |
Natural and herbal compounds targeting breast cancer, a review based on cancer stem cells |
title_sort |
natural and herbal compounds targeting breast cancer, a review based on cancer stem cells |
publisher |
Mashhad University of Medical Sciences |
series |
Iranian Journal of Basic Medical Sciences |
issn |
2008-3866 2008-3874 |
publishDate |
2020-08-01 |
description |
Cancer stem cells (CSCs) are known as the major reason for therapy resistance. Recently, natural herbal compounds are suggested to have a significant role in inhibiting the breast cancer stem cells (BCSCs). The aim of this study was to explore the effective natural herbal compounds against BCSCs.This review article was designed based on the BCSCs, mechanisms of therapy resistance and natural herbal compounds effective to inhibit their activity. Therefore, Science direct, PubMed and Scopus databases were explored and related original articles were investigated from 2010 to 2019. BCSCs use different mechanisms including special membrane transporters, anti-apoptotic, pro-survival, and self-renewal- related signaling pathways. Natural herbal compounds could disturb these mechanisms, therefore may inhibit or eradicate the BCSCs. Studies show that a broad range of plants, either as a food or medicine, contain anti-cancer agents that phenolic components and their different derivatives share a large quantity. Natural herbal compounds play a pivotal role in the eradication of BCSCs, through the inhibition of biological activities and induction of apoptosis. Although it is necessary to conduct more clinical investigation. |
topic |
breast neoplasm neoplasm phenolic compounds stem cells therapy resistance |
url |
http://ijbms.mums.ac.ir/article_15702_64a6a6eac1e2316923743951d2df3433.pdf |
work_keys_str_mv |
AT azambozorgi naturalandherbalcompoundstargetingbreastcancerareviewbasedoncancerstemcells AT saberkhazaei naturalandherbalcompoundstargetingbreastcancerareviewbasedoncancerstemcells AT abbasalikhademi naturalandherbalcompoundstargetingbreastcancerareviewbasedoncancerstemcells AT mozafarkhazaei naturalandherbalcompoundstargetingbreastcancerareviewbasedoncancerstemcells |
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