Multisystem inflammatory syndrome in children. An emerging clinical challenge for pediatric surgeons in the COVID 19 era
Background/purpose: Multisystem inflammatory syndrome in children (MIS-C) is a potentially life-threatening condition occurring 2–6 weeks after Coronavirus disease 2019 (COVID-19) in previously healthy children and adolescents, characterized by clinical and laboratory evidence of multiorgan inflamma...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-06-01
|
Series: | Journal of Pediatric Surgery Case Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213576621000609 |
id |
doaj-ab8d469a9408461d9a19c934a797cf72 |
---|---|
record_format |
Article |
spelling |
doaj-ab8d469a9408461d9a19c934a797cf722021-05-08T04:22:38ZengElsevierJournal of Pediatric Surgery Case Reports2213-57662021-06-0169101838Multisystem inflammatory syndrome in children. An emerging clinical challenge for pediatric surgeons in the COVID 19 eraFrancesco Valitutti0Alessandra Verde1Angela Pepe2Eduardo Sorrentino3Deborah Veneruso4Giusy Ranucci5Francesca Orlando6Augusto Mastrominico7Mia Giovanna Grella8Claudia Mandato9Clinical Pediatrics and Pediatrics, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy; EBRIS (European Biomedical Research Institute of Salerno), Salerno, ItalyDepartment of Traslational Medicine, University of Naples Federico II, Naples, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, Pediatrics Section, University of Salerno, Baronissi (Salerno), ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, Pediatrics Section, University of Salerno, Baronissi (Salerno), ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, Pediatrics Section, University of Salerno, Baronissi (Salerno), ItalyDepartment of Pediatrics, Santobono Pausilipon Children's Hospital, Naples, ItalyDepartment of Pediatrics, Santobono Pausilipon Children's Hospital, Naples, ItalyDepartment of Pediatrics, Santobono Pausilipon Children's Hospital, Naples, ItalyDepartment of Pediatric Surgery, Santobono Pausilipon Children's Hospital, Naples, ItalyDepartment of Pediatrics, Santobono Pausilipon Children's Hospital, Naples, Italy; Corresponding author. Department of Pediatrics, Santobono-Pausilipon Children's Hospital, Via Mario Fiore, 6, 80129, Naples, Italy.Background/purpose: Multisystem inflammatory syndrome in children (MIS-C) is a potentially life-threatening condition occurring 2–6 weeks after Coronavirus disease 2019 (COVID-19) in previously healthy children and adolescents, characterized by clinical and laboratory evidence of multiorgan inflammation. We reported the case of a 6-year-old child presented with acute abdomen and then diagnosed with MIS-C. In addition, to better portray this new entity, we performed a systematic review of MIS-C gastrointestinal features and particularly on those mimicking surgical emergencies. Methods: We described the clinical presentation, the diagnostic approach and the therapeutic outcomes of our MIS-C patient. Parallel to this, we conducted a systematic literature search using Google Scholar, PubMed, EMBASE, Scopus, focusing on gastrointestinal MIS-C. Results: Our patient was initially assessed by the surgical team due to his query acute abdomen. Following the diagnosis of MIS-C with myocarditis, intravenous methylprednisolone (2 mg/Kg/day) and intravenous immunoglobulins (2 gr/Kg single infusion) were promptly started, leading to clinical improvement. According to our literature search, patients with MIS-C have a high rate of severe abdominal symptoms resembling surgical emergencies (appendicitis, obstruction, etc.) and a not negligible number of those patients have been surgically explored with variable findings. Conclusions: We encourage pediatric surgeons in the upcoming months of COVID-19 pandemic to evaluate myocardial function prior to surgical abdominal exploration. In children with query acute abdomen, MIS-C should be promptly ruled out in order to avoid unnecessary surgeries that could worsen the already frail outcome of this new syndrome. Nevertheless, it should be considered that MIS-C might well encompass complications (e.g. appendicitis, segmental intestinal ischemia) which need swift surgical treatment.http://www.sciencedirect.com/science/article/pii/S2213576621000609Multisystem inflammatory syndrome in childrenCOVID-19GastrointestinalAcute abdomenEmergency surgery |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Francesco Valitutti Alessandra Verde Angela Pepe Eduardo Sorrentino Deborah Veneruso Giusy Ranucci Francesca Orlando Augusto Mastrominico Mia Giovanna Grella Claudia Mandato |
spellingShingle |
Francesco Valitutti Alessandra Verde Angela Pepe Eduardo Sorrentino Deborah Veneruso Giusy Ranucci Francesca Orlando Augusto Mastrominico Mia Giovanna Grella Claudia Mandato Multisystem inflammatory syndrome in children. An emerging clinical challenge for pediatric surgeons in the COVID 19 era Journal of Pediatric Surgery Case Reports Multisystem inflammatory syndrome in children COVID-19 Gastrointestinal Acute abdomen Emergency surgery |
author_facet |
Francesco Valitutti Alessandra Verde Angela Pepe Eduardo Sorrentino Deborah Veneruso Giusy Ranucci Francesca Orlando Augusto Mastrominico Mia Giovanna Grella Claudia Mandato |
author_sort |
Francesco Valitutti |
title |
Multisystem inflammatory syndrome in children. An emerging clinical challenge for pediatric surgeons in the COVID 19 era |
title_short |
Multisystem inflammatory syndrome in children. An emerging clinical challenge for pediatric surgeons in the COVID 19 era |
title_full |
Multisystem inflammatory syndrome in children. An emerging clinical challenge for pediatric surgeons in the COVID 19 era |
title_fullStr |
Multisystem inflammatory syndrome in children. An emerging clinical challenge for pediatric surgeons in the COVID 19 era |
title_full_unstemmed |
Multisystem inflammatory syndrome in children. An emerging clinical challenge for pediatric surgeons in the COVID 19 era |
title_sort |
multisystem inflammatory syndrome in children. an emerging clinical challenge for pediatric surgeons in the covid 19 era |
publisher |
Elsevier |
series |
Journal of Pediatric Surgery Case Reports |
issn |
2213-5766 |
publishDate |
2021-06-01 |
description |
Background/purpose: Multisystem inflammatory syndrome in children (MIS-C) is a potentially life-threatening condition occurring 2–6 weeks after Coronavirus disease 2019 (COVID-19) in previously healthy children and adolescents, characterized by clinical and laboratory evidence of multiorgan inflammation. We reported the case of a 6-year-old child presented with acute abdomen and then diagnosed with MIS-C. In addition, to better portray this new entity, we performed a systematic review of MIS-C gastrointestinal features and particularly on those mimicking surgical emergencies. Methods: We described the clinical presentation, the diagnostic approach and the therapeutic outcomes of our MIS-C patient. Parallel to this, we conducted a systematic literature search using Google Scholar, PubMed, EMBASE, Scopus, focusing on gastrointestinal MIS-C. Results: Our patient was initially assessed by the surgical team due to his query acute abdomen. Following the diagnosis of MIS-C with myocarditis, intravenous methylprednisolone (2 mg/Kg/day) and intravenous immunoglobulins (2 gr/Kg single infusion) were promptly started, leading to clinical improvement. According to our literature search, patients with MIS-C have a high rate of severe abdominal symptoms resembling surgical emergencies (appendicitis, obstruction, etc.) and a not negligible number of those patients have been surgically explored with variable findings. Conclusions: We encourage pediatric surgeons in the upcoming months of COVID-19 pandemic to evaluate myocardial function prior to surgical abdominal exploration. In children with query acute abdomen, MIS-C should be promptly ruled out in order to avoid unnecessary surgeries that could worsen the already frail outcome of this new syndrome. Nevertheless, it should be considered that MIS-C might well encompass complications (e.g. appendicitis, segmental intestinal ischemia) which need swift surgical treatment. |
topic |
Multisystem inflammatory syndrome in children COVID-19 Gastrointestinal Acute abdomen Emergency surgery |
url |
http://www.sciencedirect.com/science/article/pii/S2213576621000609 |
work_keys_str_mv |
AT francescovalitutti multisysteminflammatorysyndromeinchildrenanemergingclinicalchallengeforpediatricsurgeonsinthecovid19era AT alessandraverde multisysteminflammatorysyndromeinchildrenanemergingclinicalchallengeforpediatricsurgeonsinthecovid19era AT angelapepe multisysteminflammatorysyndromeinchildrenanemergingclinicalchallengeforpediatricsurgeonsinthecovid19era AT eduardosorrentino multisysteminflammatorysyndromeinchildrenanemergingclinicalchallengeforpediatricsurgeonsinthecovid19era AT deborahveneruso multisysteminflammatorysyndromeinchildrenanemergingclinicalchallengeforpediatricsurgeonsinthecovid19era AT giusyranucci multisysteminflammatorysyndromeinchildrenanemergingclinicalchallengeforpediatricsurgeonsinthecovid19era AT francescaorlando multisysteminflammatorysyndromeinchildrenanemergingclinicalchallengeforpediatricsurgeonsinthecovid19era AT augustomastrominico multisysteminflammatorysyndromeinchildrenanemergingclinicalchallengeforpediatricsurgeonsinthecovid19era AT miagiovannagrella multisysteminflammatorysyndromeinchildrenanemergingclinicalchallengeforpediatricsurgeonsinthecovid19era AT claudiamandato multisysteminflammatorysyndromeinchildrenanemergingclinicalchallengeforpediatricsurgeonsinthecovid19era |
_version_ |
1721455179375575040 |