Metal-Organic Frameworks (MOFs)-Based Nanomaterials for Drug Delivery
The composition and topology of metal-organic frameworks (MOFs) are exceptionally tailorable; moreover, they are extremely porous and represent an excellent Brunauer–Emmett–Teller (BET) surface area (≈3000–6000 m<sup>2</sup>·g<sup>−1</sup>). Nanoscale MOFs (NMOFs), as cargo n...
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doaj-ab920142e8f64595a865b269fbeb94422021-07-15T15:40:52ZengMDPI AGMaterials1996-19442021-06-01143652365210.3390/ma14133652Metal-Organic Frameworks (MOFs)-Based Nanomaterials for Drug DeliveryMohammad Reza Saeb0Navid Rabiee1Masoud Mozafari2Ebrahim Mostafavi3Université de Lorraine, CentraleSupélec, LMOPS, F-57000 Metz, FranceDepartment of Chemistry, Sharif University of Technology, Tehran 11155-3516, IranDepartment of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran 14665-354, IranStanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, USAThe composition and topology of metal-organic frameworks (MOFs) are exceptionally tailorable; moreover, they are extremely porous and represent an excellent Brunauer–Emmett–Teller (BET) surface area (≈3000–6000 m<sup>2</sup>·g<sup>−1</sup>). Nanoscale MOFs (NMOFs), as cargo nanocarriers, have increasingly attracted the attention of scientists and biotechnologists during the past decade, in parallel with the evolution in the use of porous nanomaterials in biomedicine. Compared to other nanoparticle-based delivery systems, such as porous nanosilica, nanomicelles, and dendrimer-encapsulated nanoparticles, NMOFs are more flexible, have a higher biodegradability potential, and can be more easily functionalized to meet the required level of host–guest interactions, while preserving a larger and fully adjustable pore window in most cases. Due to these unique properties, NMOFs have the potential to carry anticancer cargos. In contrast to almost all porous materials, MOFs can be synthesized in diverse morphologies, including spherical, ellipsoidal, cubic, hexagonal, and octahedral, which facilitates the acceptance of various drugs and genes.https://www.mdpi.com/1996-1944/14/13/3652metal-organic frameworksdrug deliverynanomedicinebiomedicine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohammad Reza Saeb Navid Rabiee Masoud Mozafari Ebrahim Mostafavi |
spellingShingle |
Mohammad Reza Saeb Navid Rabiee Masoud Mozafari Ebrahim Mostafavi Metal-Organic Frameworks (MOFs)-Based Nanomaterials for Drug Delivery Materials metal-organic frameworks drug delivery nanomedicine biomedicine |
author_facet |
Mohammad Reza Saeb Navid Rabiee Masoud Mozafari Ebrahim Mostafavi |
author_sort |
Mohammad Reza Saeb |
title |
Metal-Organic Frameworks (MOFs)-Based Nanomaterials for Drug Delivery |
title_short |
Metal-Organic Frameworks (MOFs)-Based Nanomaterials for Drug Delivery |
title_full |
Metal-Organic Frameworks (MOFs)-Based Nanomaterials for Drug Delivery |
title_fullStr |
Metal-Organic Frameworks (MOFs)-Based Nanomaterials for Drug Delivery |
title_full_unstemmed |
Metal-Organic Frameworks (MOFs)-Based Nanomaterials for Drug Delivery |
title_sort |
metal-organic frameworks (mofs)-based nanomaterials for drug delivery |
publisher |
MDPI AG |
series |
Materials |
issn |
1996-1944 |
publishDate |
2021-06-01 |
description |
The composition and topology of metal-organic frameworks (MOFs) are exceptionally tailorable; moreover, they are extremely porous and represent an excellent Brunauer–Emmett–Teller (BET) surface area (≈3000–6000 m<sup>2</sup>·g<sup>−1</sup>). Nanoscale MOFs (NMOFs), as cargo nanocarriers, have increasingly attracted the attention of scientists and biotechnologists during the past decade, in parallel with the evolution in the use of porous nanomaterials in biomedicine. Compared to other nanoparticle-based delivery systems, such as porous nanosilica, nanomicelles, and dendrimer-encapsulated nanoparticles, NMOFs are more flexible, have a higher biodegradability potential, and can be more easily functionalized to meet the required level of host–guest interactions, while preserving a larger and fully adjustable pore window in most cases. Due to these unique properties, NMOFs have the potential to carry anticancer cargos. In contrast to almost all porous materials, MOFs can be synthesized in diverse morphologies, including spherical, ellipsoidal, cubic, hexagonal, and octahedral, which facilitates the acceptance of various drugs and genes. |
topic |
metal-organic frameworks drug delivery nanomedicine biomedicine |
url |
https://www.mdpi.com/1996-1944/14/13/3652 |
work_keys_str_mv |
AT mohammadrezasaeb metalorganicframeworksmofsbasednanomaterialsfordrugdelivery AT navidrabiee metalorganicframeworksmofsbasednanomaterialsfordrugdelivery AT masoudmozafari metalorganicframeworksmofsbasednanomaterialsfordrugdelivery AT ebrahimmostafavi metalorganicframeworksmofsbasednanomaterialsfordrugdelivery |
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1721299016649539584 |